Date published: 2025-9-7

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Complexin-3 抗体 (C-8): sc-365941

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说明书
  • Complexin-3 抗体 C-8 是小鼠单克隆 IgG2a (kappa轻链),Complexin-3抗体,规格为200 µg/ml
  • 免疫原氨基酸序列1-44位于human物种的Complexin-3的N-terminus
  • Complexin-3 抗体 (C-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA,检测mouse, rat 和human 来源的 Complexin-3
  • 抗Complexin-3抗体(C-8)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Complexin-3 (C-8): sc-365941免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成Complexin-3 抗体 (C-8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    Complexin-3抗体(C-8)是一种IgG2a κ小鼠单克隆Complexin-3抗体(也称为Complexin-3抗体),可通过WB、IP、IF、IHC(P)和ELISA技术检测小鼠、大鼠和人类来源的Complexin-3蛋白。Complexin-3抗体(C-8)既可以作为非偶联形式的抗Complexin-3抗体,也可以作为多种偶联形式的抗Complexin-3抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Complexin蛋白家族成员通过α-螺旋结构域与Syntaxin结合,促进SNARE(可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体)预复合物的形成。Complexins是钙依赖性神经递质释放晚期或快速同步递质释放钙触发步骤后立即释放递质的重要调节因子。缺乏Complexins的神经元由于突触分泌过程对钙的敏感性降低,显示出递质释放效率降低。Complexin-3,也称为CPXIII、CPX-III、Nbla11589或CPLX3,是complexin/synaphin家族的158个氨基酸成员。Complexin-3参与突触囊泡胞吐的调节。Complexin-3与含有SNAP 25、VAMP-2和Syntaxin 1的SNARE核心复合物结合。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Complexin-3 抗体 (C-8) 参考文献:

    1. 复合素与神经元 SNARE 复合体的选择性相互作用。确定结合区域。  |  Pabst, S., et al. 2000. J Biol Chem. 275: 19808-18. PMID: 10777504
    2. 精神分裂症, 双相情感障碍和重度抑郁症的海马突触病理学:对复合素 mRNA 的研究。  |  Eastwood, SL. and Harrison, PJ. 2000. Mol Psychiatry. 5: 425-32. PMID: 10889554
    3. 复合素 II 在海马 CA1 区突触可塑性中的参与:利用缺乏复合素 II 的小鼠。  |  Huang, GZ., et al. 2000. Jpn J Pharmacol. 84: 179-87. PMID: 11128041
    4. 复合蛋白调节 Ca2+ 依赖性神经递质释放的后期步骤  |  Reim, K., et al. 2001. Cell. 104: 71-81. PMID: 11163241
    5. 突触素/复合素的 SNARE 复合物寡聚化对突触囊泡的外吞作用至关重要。  |  Tokumaru, H., et al. 2001. Cell. 104: 421-32. PMID: 11239399
    6. 复合素能促进哺乳动物中枢神经系统兴奋性和抑制性突触的神经递质释放。  |  Xue, M., et al. 2008. Proc Natl Acad Sci U S A. 105: 7875-80. PMID: 18505837
    7. 络氨酸和 Ca2+ 可刺激 SNARE 介导的膜融合。  |  Yoon, TY., et al. 2008. Nat Struct Mol Biol. 15: 707-13. PMID: 18552825
    8. 缺乏复合素 3 和复合素 4 时视网膜带状突触的功能和结构异常。  |  Reim, K., et al. 2009. J Cell Sci. 122: 1352-61. PMID: 19386896
    9. 复合蛋白:调节 SNAP 受体功能的细胞膜蛋白。  |  McMahon, HT., et al. 1995. Cell. 83: 111-9. PMID: 7553862

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Complexin-3 抗体 (C-8)

    sc-365941
    200 µg/ml
    RMB2377.00

    Complexin-3 抗体 (C-8) AC

    sc-365941 AC
    500 µg/ml, 25% agarose
    RMB3129.00

    Complexin-3 抗体 (C-8) HRP

    sc-365941 HRP
    200 µg/ml
    RMB2377.00

    Complexin-3 抗体 (C-8) FITC

    sc-365941 FITC
    200 µg/ml
    RMB2482.00

    Complexin-3 抗体 (C-8) PE

    sc-365941 PE
    200 µg/ml
    RMB2580.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 488

    sc-365941 AF488
    200 µg/ml
    RMB2685.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 546

    sc-365941 AF546
    200 µg/ml
    RMB2685.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 594

    sc-365941 AF594
    200 µg/ml
    RMB2685.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 647

    sc-365941 AF647
    200 µg/ml
    RMB2685.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 680

    sc-365941 AF680
    200 µg/ml
    RMB2685.00

    Complexin-3 抗体 (C-8) Alexa Fluor® 790

    sc-365941 AF790
    200 µg/ml
    RMB2685.00

    Can Complexin-3 (C-8): sc-365941 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: jenniferc
    Thank you for your question. Yes, Complexin-3 (C-8): sc-365941 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-28
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    Rated 5 out of 5 by from Produced excellent immunoperoxidase cytoplasmicProduced excellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human prostate tissue. -SCBT QC
    Date published: 2015-05-08
    Rated 5 out of 5 by from Produced positive Western Blot data of ComplexinProduced positive Western Blot data of Complexin-3 expression in non-transfected and mouse Complexin-3 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-10-31
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    Complexin-3 抗体 (C-8) is rated 5.0 out of 5 by 2.
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