Date published: 2025-9-7

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CNOT2 抗体 (2191C2a): sc-81229

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说明书
  • CNOT2 抗体 2191C2a 是小鼠单克隆 IgG2aCNOT2抗体, 在1篇文献中引用,规格为100 µg/ml
  • 针对与human起源的CNOT2的内部区域对应的重组蛋白
  • 推荐用于 human 来源的CNOT2 WB 和 IP检测
  • 关于如何获取CNOT2 (2191C2a): sc-81229免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成CNOT2 抗体 (2191C2a)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

CNOT2抗体(2191C2a)是一种IgG2a小鼠单克隆CNOT2抗体,可通过WB和IP检测人源CNOT2蛋白。CNOT2抗体(2191C2a)以非偶联抗CNOT2抗体形式提供。CNOT2(CCR4-NOT转录复合物亚基2)是一种由人类基因CNOT2编码的普遍存在的蛋白质。CNOT2属于CNOT2/3/5家族,并且是CCR4-NOT复合物的一部分。CCR4-NOT复合物是一种进化上保守的多组分复合物,已知参与转录和mRNA降解。各种亚基(例如CNOT1、CNOT2)参与影响核激素受体活动。CCR4-NOT复合物还通过可能涉及蛋白酶体的泛素依赖性途径参与组蛋白H3赖氨酸4甲基化的调节。CNOT2亚基的表达增加可通过RNA聚合酶II强烈抑制转录。这种抑制效应是由位于CNOT2蛋白C末端的保守NOT-Box介导的。NOT-Box的抑制作用对组蛋白去乙酰化酶(HDAC)抑制剂曲古抑菌素A的处理敏感。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CNOT2 抗体 (2191C2a) 参考文献:

  1. 转录调控 Ccr4-not 复合物的一个亚基 CNOT2 对启动子活性的抑制。  |  Zwartjes, CG., et al. 2004. J Biol Chem. 279: 10848-54. PMID: 14707134
  2. Ccr4-Not复合体通过新发现的Glc7/Bud14 I型蛋白磷酸酶模块独立控制Msn2依赖性转录激活和TFIID启动子分布。  |  Lenssen, E., et al. 2005. Mol Cell Biol. 25: 488-98. PMID: 15601868
  3. 细胞周期蛋白依赖性激酶 11 与 NOT2 相互作用。  |  Shi, J. and Nelson, MA. 2005. Biochem Biophys Res Commun. 334: 1310-6. PMID: 16039607
  4. SMRT/NCoR-HDAC3 复合物参与了人类 Ccr4-Not 复合物 CNOT2 亚基的转录抑制作用。  |  Jayne, S., et al. 2006. Biochem J. 398: 461-7. PMID: 16712523
  5. 人类 Ccr4-Not 复合物是核受体介导转录的配体依赖性抑制因子。  |  Winkler, GS., et al. 2006. EMBO J. 25: 3089-99. PMID: 16778766
  6. CCR4/NOT 复合物与蛋白酶体结合并调节组蛋白甲基化。  |  Laribee, RN., et al. 2007. Proc Natl Acad Sci U S A. 104: 5836-41. PMID: 17389396
  7. CCR4-NOT 复合物的成分通过与 NRC 结合因子 NIF-1 缔合,发挥核激素受体辅激活剂的作用。  |  Garapaty, S., et al. 2008. J Biol Chem. 283: 6806-16. PMID: 18180299
  8. CNOT2 通过血管内皮生长因子信号促进 MDA-MB-231 乳腺癌细胞的增殖和血管生成。  |  Sohn, EJ., et al. 2018. Cancer Lett. 412: 88-98. PMID: 29024811
  9. CNOT2单倍体缺陷的临床特征描述和IDNADFS表型概述。  |  Niceta, M., et al. 2023. Clin Genet. 103: 156-166. PMID: 36224108
  10. 雏鸡脐带发生过程中聚类同源基因 CNOT2 和 CNOT1 的不同激活。  |  Stein, S., et al. 1996. Dev Biol. 180: 519-33. PMID: 8954724
  11. 雏鸡胚胎的形成和同源染色体基因  |  Lemaire, L. and Kessel, M. 1997. Mech Dev. 67: 3-16. PMID: 9347911

订购信息

产品名称产品编号规格价格数量收藏夹

CNOT2 抗体 (2191C2a)

sc-81229
100 µg/ml
RMB2504.00

Would it be possible to receive a free sample of this antibody (CNOT2 (2191C2a): sc-81229)?

Asked by: Hedda
Thank you for your question. Please contact Technical Service for more information on how to receive a 10 μg sample of our well characterized monoclonal antibody.
Answered by: Technical Support
Date published: 2018-12-05

I am using CNOT2 (2191C2a): sc-81229 antibody for immunoprecipitation, how much antibody should I use?

Asked by: cjMara
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Good for Western BlotAntibody works well for detection of CNOT2 by Western Blot in human cell line HeLa. -SCBT QC
Date published: 2023-09-14
Rated 1 out of 5 by from Bad for western blotWe tried 1:1000 dilution for mouse cell lysis. The background is very high. Not recommend!
Date published: 2017-08-14
Rated 5 out of 5 by from This antibody works well on WB (1/250) withThis antibody works well on WB (1/250) with ECL Prime detection
Date published: 2016-09-21
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CNOT2 抗体 (2191C2a) is rated 3.8 out of 5 by 4.
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