Date published: 2025-9-9

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CLPTM1 抗体 (C-2): sc-398443

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说明书
  • CLPTM1抗体(C-2)是小鼠单克隆IgG2a (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的CLPTM1的C-terminus附近的氨基酸579-608之间
  • 推荐用于 human 来源的CLPTM1 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是CLPTM1 Antibody (C-2) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CLPTM1 Antibody (C-2) 打包提供(请参阅下面的订购信息)。

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    関連項目

    口腔颌面部的裂口通常发生在胎儿早期发育过程中,可能影响到嘴唇、软腭(口腔后部的软组织)和硬腭(口腔顶部)。唇裂(伴或不伴腭裂)是一种遗传上复杂的出生缺陷,大约每750-1000个活产儿中就有1例。这是最常见的出生缺陷之一,具有多因素性,既有遗传原因,也有环境原因。唇腭裂相关跨膜蛋白1(CLPTM1)属于唇腭裂跨膜蛋白家族。这个家族还包含顺铂耐药相关蛋白(CRR9),后者参与CDDP诱导的细胞凋亡。CLPTM1蛋白与两个秀丽隐杆线虫基因具有很强的同源性。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    CLPTM1 抗体 (C-2) 参考文献:

    1. 利用抑制无义介导的衰变和芯片分析鉴定前列腺癌细胞中 JAK1, SYNJ2 和 CLPTM1 基因的失活突变。  |  Rossi, MR., et al. 2005. Cancer Genet Cytogenet. 161: 97-103. PMID: 16102578
    2. 人类唇腭裂成纤维细胞和经尼古丁处理的正常成纤维细胞显示出与分子信号通路和细胞外基质代谢有关的基因体外表达发生了改变。  |  Baroni, T., et al. 2010. J Cell Physiol. 222: 748-56. PMID: 20020508
    3. TERT-CLPTM1位点多态性(rs401681)与非小细胞肺癌表皮生长因子受体突变有关。  |  Lee, DH., et al. 2017. Pathol Res Pract. 213: 1340-1343. PMID: 29033187
    4. Clptm1 限制 GABAA 受体的前向贩运,从而调节抑制性突触强度。  |  Ge, Y., et al. 2018. Neuron. 97: 596-610.e8. PMID: 29395912
    5. 遗传效应和基因与教育的相互作用对老龄人口的外显记忆表现和衰退的影响。  |  Smith, JA., et al. 2021. Soc Sci Med. 271: 112039. PMID: 30449520
    6. 腭裂跨膜蛋白 1 家族蛋白在口腔鳞状细胞癌中的病理生物学作用。  |  Inoue, K., et al. 2019. J Cancer Res Clin Oncol. 145: 851-859. PMID: 30635792
    7. 跨膜附属蛋白对 GABAARs 的调控。  |  Han, W., et al. 2021. Trends Neurosci. 44: 152-165. PMID: 33234346
    8. 白细胞端粒相对长度和端粒相关基因(TERT、TERT-CLPTM1、TRF1、TNKS2、TRF2)的遗传变异与萎缩性老年黄斑变性的关系。  |  Banevicius, M., et al. 2021. Ophthalmic Genet. 42: 189-194. PMID: 33565341
    9. 一种脂质扰乱酶 TMEM41B 参与了 GPI-anchored 蛋白的加工和转运。  |  Cao, SY., et al. 2023. J Biochem. 174: 109-123. PMID: 37279648
    10. 癫痫患者中GABAA R电流反应减弱的新生CLPTM1变体。  |  Liu, N., et al. 2023. Epilepsia. 64: 2968-2981. PMID: 37577761

    订购信息

    产品名称产品编号规格价格数量收藏夹

    CLPTM1 抗体 (C-2)

    sc-398443
    200 µg/ml
    RMB2377.00

    CLPTM1 (C-2): m-IgG Fc BP-HRP 套装

    sc-538444
    200 µg Ab; 10 µg BP
    RMB2662.00

    CLPTM1 (C-2): m-IgGκ BP-HRP 套装

    sc-536060
    200 µg Ab; 40 µg BP
    RMB2662.00

    CLPTM1 (C-2): m-IgG2a BP-HRP 套装

    sc-548303
    200 µg Ab; 10 µg BP
    RMB2662.00

    CLPTM1 (C-2) 中和勝肽

    sc-398443 P
    100 µg/0.5 ml
    RMB511.00

    The predicted molecular weight of CLPTM1 is 76kDa, why does it show a significant larger size on you WB?

    Asked by: Cecilia Drakskog
    Thank you for your question. The western blot on the product page shows cells transfected with recombinant protein rather than endogenous expression. In non-transfected cells with endogenous expression, the antibody will detect the CLPTM1 at its molecular weight of 76 kDa.
    Answered by: Tech Support Europe
    Date published: 2023-01-26

    What application is the blocking peptide sc-398443 P appropriate for?

    Asked by: Germaine
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Good Western blot data of CLPTM1 expression in nonGood Western blot data of CLPTM1 expression in non-transfected and human CLPTM1 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-12-07
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    CLPTM1 抗体 (C-2) is rated 5.0 out of 5 by 1.
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