CLEC-2 抗体 (53Ex9): sc-73851

CLEC-2 (C-type lectin-like receptor 2), also referred to as C-type lectin domain family 1 member B, is a monomeric, single pass, type II membrane protein belonging to a non-classical C-type lectin class of platelet activating receptors. It is expressed on the surface of platelets, immune cells of myeloid origin and in liver. C-type lectin receptors play important roles in pathogen recognition within the immune system. CLEC-2 acts as a receptor for the snake venom protein, rhodocytin. It also acts as a co-receptor for HIV-1, promoting virus capture by cells and platelets. Activation of CLEC-2 involves the tyrosine phosphorylation of its cytoplasmic tail. It signals by the activation of PLCγ2 through Src and Syk dependent pathways which lead to platelet activation and aggregation. In addition, CLEC-2 interacts with podoplanin, a sialoglycoprotein, and together they may regulate tumor growth and play a role in the formation of lymphatic vessels.