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cleaved Rock-1 抗体 (154C1465): sc-52953

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说明书
  • cleaved Rock-1 抗体 154C1465 是小鼠单克隆 IgG, 在5篇文献中引用,提供 100 µg/ml
  • 针对Rock-1的半胱天冬酶-3切割位点(对应氨基酸11131114)(human起源)
  • 推荐用于 mouse, rat, human 和 canine 来源的the cleaved C-terminus of Rock-1 WB 和 IP检测; 还建议用于检测the full-length protein
  • 目前,我们还没有完成cleaved Rock-1 抗体 (154C1465)的首选二抗检测试剂的鉴定。这项工作正在进行中。
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裂解的 Rock-1 抗体(154C1465)是一种小鼠单克隆 IgG,专门设计用于识别裂解的 ROCK1(Rho 相关的含线圈蛋白激酶 1)的 C-端。抗 ROCK1 抗体(154C1465)靶向与人 ROCK1 的 1113-1114 氨基酸相对应的 caspase-3 分裂位点,对人、小鼠、大鼠和犬样本均有反应。ROCK1 又称 p160ROCK 或 ROKβ,是一种丝氨酸/苏氨酸激酶,与肌动蛋白细胞骨架、细胞运动、收缩和细胞凋亡的调节密不可分。在细胞凋亡过程中,caspase-3 会裂解 ROCK1,使其形成具有组成活性的形式,从而增强肌球蛋白轻链(MLC)等底物的磷酸化,导致膜裂,这是凋亡细胞的一个特征。抗 ROCK1 抗体(154C1465)适用于在免疫印迹(WB)和免疫沉淀(IP)试验中检测 ROCK1 的裂解形式和全长形式,因此该试剂是研究癌症进展和细胞迁移等各种生物过程中细胞凋亡和细胞骨架动态的重要工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

cleaved Rock-1 抗体 (154C1465) 参考文献:

  1. caspase-3裂解激活Rho相关螺旋蛋白激酶1(ROCK-1)在心肌细胞凋亡中发挥重要作用。  |  Chang, J., et al. 2006. Proc Natl Acad Sci U S A. 103: 14495-500. PMID: 16983089
  2. 欧亚班诱导的细胞凋亡和 Rho 激酶:一个新的 caspase-2 裂解位点和 Rock-2 片段。  |  Ark, M., et al. 2010. Apoptosis. 15: 1494-506. PMID: 20661774
  3. 乙肝疫苗诱导Hepa1-6细胞凋亡。  |  Hamza, H., et al. 2012. Apoptosis. 17: 516-27. PMID: 22249285
  4. 药物抑制 ROCK2 可抑制阿尔茨海默病小鼠模型中淀粉样蛋白-β的生成。  |  Herskowitz, JH., et al. 2013. J Neurosci. 33: 19086-98. PMID: 24305806
  5. MicroRNA-582-5p通过靶向ROCK1减少异丙酚诱导的发育中神经元凋亡。  |  Zhang, Z., et al. 2020. Curr Neurovasc Res. 17: 140-146. PMID: 32031069
  6. MicroRNA-135a-5p通过靶向SP1和ROCK促进脊髓损伤的功能恢复。  |  Wang, N., et al. 2020. Mol Ther Nucleic Acids. 22: 1063-1077. PMID: 33294293
  7. 细胞死亡中ROCK 1的一种新型蛋白水解裂解:不仅通过半胱天冬酶3和7,还通过半胱天冬酶2。  |  Özdemir, A., et al. 2021. Biochem Biophys Res Commun. 547: 118-124. PMID: 33610039
  8. miR-148a-3p通过调节ROCK-1的表达抑制膀胱癌的增殖和迁移。  |  Xu, C., et al. 2022. PeerJ. 10: e12724. PMID: 35127282
  9. 胆固醇瘤患者中的RhoA、ROCK-1和ROCK-2基因表达和多态性。  |  Görür, K., et al. 2021. J Int Adv Otol. 17: 530-535. PMID: 35177391
  10. [茯苓多糖通过调节Rho-ROCK信号通路对心肌缺血再灌注损伤大鼠心肌细胞凋亡的影响及机制]  |  Xie, J., et al. 2023. Zhongguo Zhong Yao Za Zhi. 48: 6434-6441. PMID: 38212001

订购信息

产品名称产品编号规格价格数量收藏夹

cleaved Rock-1 抗体 (154C1465)

sc-52953
100 µg/ml
$322.00

I am using cleaved Rock-1 (154C1465): sc-52953 antibody for immunoprecipitation, how much antibody should I use?

Asked by: jenniferc
Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by Julie from Used on a regular basis and published as wellUsed on a regular basis and published as well. They are working great for us.
Date published: 2015-05-28
Rated 5 out of 5 by JM from Great antibody for WesternGreat antibody for Western, strong band detected in K-562 and F9. -SCBT QC
Date published: 2015-05-04
Rated 5 out of 5 by ET from Worked well in WB with rat pup intrapulmonaryWorked well in WB with rat pup intrapulmonary arteries. -SCBT Publication Review
Date published: 2015-03-13
Rated 4 out of 5 by QZ from Strong WB band achieved in Jurkat whole cellStrong WB band achieved in Jurkat whole cell lysate. -SCBT QC
Date published: 2015-02-19
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cleaved Rock-1 抗体 (154C1465) is rated 4.8 out of 5 by 4.
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