Date published: 2025-9-8
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CIRP Antibody (1C9) - Immunofluorescence - Image 346113
CIRP 抗体 (1C9): sc-293325. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示核和核仁定位.
CIRP Antibody (1C9) - Immunofluorescence - Image 346113
CIRP 抗体 (1C9): sc-293325. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示核和核仁定位.
CIRP Antibody (1C9) - Western Blotting - Image 347541
CIRP 抗体 (1C9): sc-293325. 非转染 (A) 和 CIRP 转染 (B) 293T 全细胞裂解液中 CIRP 表达的 Western 印迹分析.
CIRP Antibody (1C9) - Western Blotting - Image 348455
CIRP 抗体 (1C9): sc-293325. 人重组 CIRP 融合蛋白的 Western 印迹分析.
CIRP 抗体 (1C9): sc-293325. 甲醇固定的 HeLa 细胞免疫荧光染色, 显示核和核仁定位.

CIRP 抗体 (1C9): sc-293325

3.7(7)
寫評論提問

说明书
  • CIRP 抗体 1C9 是小鼠单克隆 IgG2a (kappa轻链)，CIRP抗体，规格为100 µg/ml
  • 免疫human物种的CIRP的氨基酸1-90
  • 推荐用于 mouse, rat 和 human 来源的CIRP WB, IP, IF, IHC(P) 和 ELISA检测
  • 关于如何获取CIRP (1C9): sc-293325的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP 和 m-IgGκ BP-HRP 是 CIRP 抗体 (1C9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CIRP 抗体 (1C9) 组合成套装提供。 (请参阅下面的订购信息)。

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    相关产品
    描述
    基因信息
    说明书与实验方案
    研究信息

    関連項目

    CIRP抗体（1C9）是一种小鼠单克隆IgG2a kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和酶联免疫吸附测定（ELISA）检测小鼠、大鼠和人类来源的CIRP蛋白。抗CIRP抗体（1C9）以非结合形式提供。CIRP，也称为冷诱导RNA结合蛋白或A18HNRNP，是一种172个氨基酸的蛋白质，在细胞应激反应中起着至关重要的作用，特别是在细胞核中，CIRP包含一个RNA识别模域。CIRP普遍表达，对于抑制细胞增殖以应对环境压力（如紫外线照射和极端寒冷）至关重要，这凸显了CIRP在维持细胞稳态中的重要性。人类CIRP与小鼠CIRP的序列相似度为95%，表明其在不同物种间具有保守的功能，这一点在子宫内膜癌等疾病中尤为重要。CIRP位于人类第19号染色体上，该区域还包含多个免疫球蛋白超家族成员，包括杀伤细胞和白细胞Ig样受体、各种细胞间粘附分子和Fc受体，这表明CIRP可能参与免疫调节和细胞信号通路。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    CIRP 抗体 (1C9) 参考文献:

    1. 哺乳动物细胞的冷休克反应  |  Fujita, J. 1999. J Mol Microbiol Biotechnol. 1: 243-55. PMID: 10943555
    2. 正常子宫内膜, 子宫内膜增生症和子宫内膜癌中冷诱导 RNA 结合蛋白的表达。  |  Hamid, AA., et al. 2003. Int J Gynecol Pathol. 22: 240-7. PMID: 12819390
    3. 氧通过 HIF-1 非依赖机制调控 RNA 结合蛋白 RBM3 和 CIRP 的表达。  |  Wellmann, S., et al. 2004. J Cell Sci. 117: 1785-94. PMID: 15075239
    4. 冷诱导 RNA 结合蛋白通过甲基化依赖机制从细胞核迁移到细胞质应激颗粒，并充当翻译抑制因子。  |  De Leeuw, F., et al. 2007. Exp Cell Res. 313: 4130-44. PMID: 17967451
    5. 一种富含甘氨酸的 RNA 结合蛋白，介导冷诱导抑制哺乳动物细胞生长。  |  Nishiyama, H., et al. 1997. J Cell Biol. 137: 899-908. PMID: 9151692
    6. 鉴定仓鼠 DNA 损伤诱导转录本的几个人类同源物。克隆并鉴定一种新型紫外线诱导 cDNA，该 cDNA 编码一种假定的 RNA 结合蛋白。  |  Sheikh, MS., et al. 1997. J Biol Chem. 272: 26720-6. PMID: 9334257
    7. 高温下雄性生殖细胞中冷诱导 RNA 结合蛋白（CIRP）的表达量减少。  |  Nishiyama, H., et al. 1998. Am J Pathol. 152: 289-96. PMID: 9422546
    8. 人类 CIRP（冷诱导 RNA 结合蛋白）cDNA 的克隆和特性鉴定以及该基因的染色体定位。  |  Nishiyama, H., et al. 1997. Gene. 204: 115-20. PMID: 9434172

    订购信息

    产品名称产品编号规格价格数量收藏夹

    CIRP 抗体 (1C9)

    sc-293325
    100 µg/ml
    		RMB2377.00

    CIRP (1C9): m-IgG Fc BP-HRP 套装

    sc-537739
    100 µg Ab; 10 µg BP
    		RMB2662.00

    CIRP (1C9): m-IgGκ BP-HRP 套装

    sc-535105
    100 µg Ab; 40 µg BP
    		RMB2662.00

    CIRP (1C9): m-IgG2a BP-HRP 套装

    sc-548103
    100 µg Ab; 10 µg BP
    		RMB2662.00

    Prezados, O CIRP Anticorpo (1C9): sc-293325 funciona para hamster sirio?

    Asked by: Dr Marcelo Alves
    Este anticorpo deve funcionar para hamster, pois a identidade de homologia é de 98%.
    Answered by: Technical Service
    Date published: 2024-04-15

    Gostaria de testar em cortes parafinados de pulmão de hamster o sc-293325: CIRP (1C9) monoclonal antibody, vc sabem se existe reatividade cruzada? Vcs poderiam fornecer uma amostra para teste?

    Asked by: marcelop
    Você precisará entrar em contato com seu distribuidor local para saber como receber uma amostra grátis. https://www.scbt.com/resources/distributors
    Answered by: Technical Service
    Date published: 2024-04-12

    请问如何获取CIRP抗体小样？有联系方式吗

    Asked by: BU LUPING
    Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
    Answered by: Tech Service
    Date published: 2019-02-25

    Can sc-293325: CIRP (1C9) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: jerojero
    Thank you for your question. Yes, sc-293325: CIRP (1C9) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-03-24
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    Rated 5 out of 5 by from Good for Western BlotAntibody detects human recombinant CIRP and CIRP transfected cell lysate by Western blot. -SCBT QC
    Date published: 2023-09-14
    Rated 1 out of 5 by from Did not work in WB and questionable in IFWe tested this antibody at 1/300 in WB and did not work. The IF at 1/100 is similar as the image but it does not look like as other anti-CIRBP antibodies locations that we have tried.
    Date published: 2019-08-13
    Rated 4 out of 5 by from It works on animal and human samples.We have tried this antibody on Western blots only. Works well on animal tissues, cultured cells, and cultured cells of human origin.
    Date published: 2018-02-06
    Rated 5 out of 5 by from 效果不错！客户使用反映挺不错的，之前客户买的其他品牌（在此就不方便说了啊）效果不是很好，售后也跟不上，头疼死了，这个挺好
    Date published: 2018-01-23
    Rated 5 out of 5 by from very good effectWe just started using this antibody for several times, because the previous one was no longer available. In the test, we found that the effect is not as obvious as before, after increasing the dilution ratio, the effect becomes very good.
    Date published: 2017-02-16
    Rated 1 out of 5 by from Did not workWe received this antibody as a replacement for SRP40 which did not work. Unfortunately this antibody has not worked either. I got a blank blot.
    Date published: 2016-12-13
    Rated 5 out of 5 by from The result is very goodThis product is convenient to use,I use this antibody do IHC，Dilution ratio of 1:500 The result is very good
    Date published: 2016-11-01
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    CIRP 抗体 (1C9) is rated 3.7 out of 5 by 7.
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