CHIR-98014 (CAS 252935-94-7)

物理状态 :

Solid

溶解度 :

Soluble in DMSO (4 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 15% Captisol/citrate vehicle (30 mg/ml at 25 °C).

保存 :

Store at -20° C

沸点 :

~795.1° C at 760 mmHg (Predicted)

密度 :

~1.6 g/cm³ (Predicted)

折射率 :

n²⁰_D 1.76 (Predicted)

IC50 :

GSK-3 β: IC₅₀ = 0.58 nM; GSK-3 α: IC₅₀ = 0.65 nM

Ki 数据 :

GSK-3 β: K_i= 0.87 nM

PubChem CID :

MDL 号码 :

MFCD10565922

SMILES :

C1=CC(=C(C=C1Cl)Cl)C2=Nxs(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N