Date published: 2025-9-7
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CEP290 Antibody (G-4) - Western Blotting - Image 371149
CEP290 抗体 (G-4): sc-390637. CCRF-CEM (A), HeLa (B) 和 K-562 (C) 全细胞裂解液中 CEP290 表达的 Western 印迹分析.
CEP290 抗体 (G-4): sc-390637. CCRF-CEM (A), HeLa (B) 和 K-562 (C) 全细胞裂解液中 CEP290 表达的 Western 印迹分析.

CEP290 抗体 (G-4): sc-390637

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说明书
  • CEP290抗体(G-4)是小鼠单克隆IgG2a κ, 在1篇文献中引用，规格为200 µg/ml
  • 免疫原氨基酸序列1441-1740位于human物种的CEP290的内部区域内
  • 推荐用于 mouse, rat 和 human 来源的CEP290 WB, IP, IF, IHC(P) 和 ELISA检测
  • m-IgG Fc BP-HRP 和 m-IgG2a BP-HRP 是 CEP290 抗体 (G-4) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CEP290 抗体 (G-4) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

抗体

中心体是哺乳动物细胞的主要微管组织中心。它们由一对中心粒和周围的微管成核物质组成，称为中心粒周围物质(PCM)。双极有丝分裂纺锤体的组装依赖于两个相互交织的过程:中心粒复制和中心体成熟。中心体复制和成熟的不协调随后与纺锤体缺陷有关，这可能导致非整倍体并促进癌症进展。CEP290(290 kDa的中心体蛋白)基因编码一个由2479个氨基酸组成的蛋白，该蛋白激活CREB-2介导的转录。具体来说，CEP290确保纤毛和光转导蛋白在视网膜光感受器细胞中的正确定位。在几种疾病中已发现CEP290基因突变，包括Joubert综合征5型(JBTS5)、Senior-Løken综合征6型(SLSN6)、Leber先天性黑蒙症10型(LCA10)和Meckel综合征4型(MKS4)。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CEP290 抗体 (G-4) 参考文献:

  1. CEP290基因转移可恢复莱伯先天性黑蒙病的细胞表型。  |  Burnight, ER., et al. 2014. Gene Ther. 21: 662-72. PMID: 24807808
  2. 小鼠CEP290等位基因会破坏组织特异性纤毛生物发生，并重现综合征性纤毛病的特征。  |  Rachel, RA., et al. 2015. Hum Mol Genet. 24: 3775-91. PMID: 25859007
  3. 茹贝尔综合征：解开遗传异质性极强的隐性疾病的模型。  |  Bachmann-Gagescu, R., et al. 2015. J Med Genet. 52: 514-22. PMID: 26092869
  4. 莱伯先天性黑蒙病因CEP290突变而致--严重视力障碍，医疗需求迫切：综述。  |  Leroy, BP., et al. 2021. Retina. 41: 898-907. PMID: 33595255
  5. 使用医学诊断试剂盒测序法，在一名莱伯先天性黑蒙患者体内发现了一种新型CEP290致病变异。  |  Chen, BB., et al. 2022. Ophthalmic Genet. 43: 97-103. PMID: 34809537
  6. CEP290相关性莱伯先天性黑蒙症的斑点状病变：病例系列。  |  Aleman, TS., et al. 2022. Ophthalmic Genet. 43: 824-833. PMID: 36469661
  7. Eupatilin可改善人类CEP290纤毛病模型中的纤毛缺陷。  |  Corral-Serrano, JC., et al. 2023. bioRxiv.. PMID: 37205323
  8. Eupatilin可改善人类CEP290纤毛病模型中的纤毛缺陷。  |  Corral-Serrano, JC., et al. 2023. Cells. 12: PMID: 37371046
  9. Cep131-Cep162和Cby-Fam92复合物共同维持基底体的Cep290，并有助于纤毛发生启动。  |  Wu, Z., et al. 2024. PLoS Biol. 22: e3002330. PMID: 38442096
  10. CEP290相关纤毛病中报告的眼外特征的频谱和频率--系统综述。  |  Vrabič, N., et al. 2024. J Fr Ophtalmol. 47: 104232. PMID: 39213781

订购信息

产品名称产品编号规格价格数量收藏夹

CEP290 抗体 (G-4)

sc-390637
200 µg/ml
RMB2377.00

CEP290 (G-4): m-IgG Fc BP-HRP 套装

sc-540826
200 µg Ab; 10 µg BP
RMB2662.00

CEP290 (G-4): m-IgG2a BP-HRP 套装

sc-546963
200 µg Ab; 10 µg BP
RMB2662.00

which region or peptide does this antibody target?

Asked by: dave23
Thank you for your question. sc-390637 CEP290 (G-4) has a epitope range of 1441-1740.
Answered by: BlakeJ
Date published: 2022-11-14

Does CEP290 Antibody (G-4) work on zebrafish? It mentioned working on mouse, rat and human. Thanks!

Asked by: Xianghong
Thank you for your question. We are not aware of anyone testing our CEP290 Antibody (G-4): sc-390637 on zebrafish samples. The antibody is raised against a portion of the human sequence that shares 61% sequence identity with the published zebrafish protein (UniProt accession number P85001). This is below our threshold for recommending the species, but since this is a monoclonal antibody, and the exact epitope is unknown, it is possible it would work for zebrafish.
Answered by: Technical Support
Date published: 2017-05-30

I am using CEP290 (G-4): sc-390637 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jenniferc
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human lower stomach tissue. -SCBT QC
Date published: 2015-04-10
Rated 5 out of 5 by from Great Western Blot data of CEP290 expressionGreat Western Blot data of CEP290 expression in CCRF-CEM whole cell lysate. -SCBT QC
Date published: 2013-01-31
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CEP290 抗体 (G-4) is rated 5.0 out of 5 by 2.
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