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CEACAM5 Antibody (26/3/13) - Western Blotting - Image 14582
CEACAM5 抗体 (26/3/13): sc-59872. 还原 (A) 和非还原 (B) 条件下 LS1034 全细胞裂解液中 CEACAM5 表达的 Western 印迹分析.
CEACAM5 Antibody (26/3/13) - Western Blotting - Image 14582
CEACAM5 抗体 (26/3/13): sc-59872. 还原 (A) 和非还原 (B) 条件下 LS1034 全细胞裂解液中 CEACAM5 表达的 Western 印迹分析.
CEACAM5 抗体 (26/3/13): sc-59872. 还原 (A) 和非还原 (B) 条件下 LS1034 全细胞裂解液中 CEACAM5 表达的 Western 印迹分析.

CEACAM5 抗体 (26/3/13): sc-59872

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说明书
  • CEACAM5抗体(26/3/13)是小鼠单克隆IgG1 (kappa轻链)，规格为200 µg/ml
  • 针对全长天然CEACAM5的抗体，来自human来源
  • 推荐用于 human 来源的CEACAM5 WB, IP, IF, FCM 和 ELISA检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 CEACAM5 (CI-P83-1): sc-23928，可查看有标记的 CEACAM5 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是CEACAM5 Antibody (26/3/13) for WB applications. 的首选辅助检测试剂，这些试剂现与CEACAM5 Antibody (26/3/13) 打包提供（请参阅下面的订购信息）。

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    描述
    基因信息
    说明书与实验方案
    研究信息

    関連項目

    额外CEACAM抗体，包括CEACAM1, CEACAM16, CEACAM19, CEACAM2, CEACAM20, CEACAM3, CEACAM5, CEACAM6和CEACAM7

    CD66 (癌胚抗原、CEA、胆汁糖蛋白I、BGP-1、CEACAM)免疫球蛋白超家族基因编码细胞黏附蛋白，其在肿瘤组织中的表达水平高于正常组织。人类CD66基因家族是由29个基因组成的一组表达于上皮细胞和造血细胞的糖蛋白家族，分布于染色体19q13.1-q13.2。CD66A、CD66B、CD66C、CD66D、CD66E和CD66F是最具特征性的CD66抗原，CD66A- d在刺激粒细胞后表达上调。某些CD66家族成员介导同型和异型细胞间粘附事件。CD66E又称CEA，是一种众所周知的肿瘤标志物，也是一种高度糖基化的连接GPI的细胞表面分子。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    CEACAM5 抗体 (26/3/13) 参考文献:

    1. 血小板癌胚抗原细胞黏附分子5（CEACAM5）作为评估急性冠脉综合征的一种可能的新型诊断工具。  |  Wan, W., et al. 2019. Med Sci Monit. 25: 9864-9874. PMID: 31865362
    2. CEACAM5的调节和抗CEACAM5-SN38抗体-药物偶联物在神经内分泌前列腺癌中的治疗功效。  |  DeLucia, DC., et al. 2021. Clin Cancer Res. 27: 759-774. PMID: 33199493
    3. 哮喘患者中CEACAM5水平升高。  |  Xu, C., et al. 2022. Int Arch Allergy Immunol. 183: 673-681. PMID: 35172310
    4. 小分子CEACAM5肽可恢复克罗恩病中CD8+调节性T细胞的保护功能。  |  Dunkin, D., et al. 2022. Gastroenterology. 163: 1090-1093.e3. PMID: 35700774
    5. CEACAM5是一种IL-13调节的上皮基因，可介导2型（T2）重度哮喘的转录。  |  Mumby, S., et al. 2022. Allergy. 77: 3463-3466. PMID: 35916059
    6. CT109-SN-38是一种新型抗体-药物偶联物，对CEACAM5和6具有双重特异性，可有效杀死胰腺癌细胞。  |  Cardenas, KCA., et al. 2024. Curr Cancer Drug Targets. 24: 720-732. PMID: 38178674
    7. 一种多模式微纤维散斑图生物传感器，用于通过人工智能诊断测量CEACAM5。  |  Liu, Y., et al. 2024. Biosensors (Basel). 14: PMID: 38275310
    8. SARS-Cov-2 刺突通过 CEACAM5 和 Galectin-9 之间的相互作用诱导肠道屏障功能障碍。  |  Luo, Y., et al. 2024. Front Immunol. 15: 1303356. PMID: 38686388
    9. 雄激素受体阴性前列腺癌中CEACAM5靶向免疫PET。  |  Imberti, C., et al. 2024. J Nucl Med. 65: 1043-1050. PMID: 38782457
    10. 针对表达CEACAM5的肿瘤的单克隆抗体的表位-配体相互作用的结构见解。  |  Kumar, A., et al. 2024. Nat Commun. 15: 9377. PMID: 39477960

    订购信息

    产品名称产品编号规格价格数量收藏夹

    CEACAM5 抗体 (26/3/13)

    sc-59872
    200 µg/ml
    		RMB2377.00

    CEACAM5 (26/3/13): m-IgG Fc BP-HRP 套装

    sc-539146
    200 µg Ab; 10 µg BP
    		RMB2662.00

    CEACAM5 (26/3/13): m-IgG1 BP-HRP 套装

    sc-541293
    200 µg Ab; 20 µg BP
    		RMB2662.00

    CEACAM5 抗体 (26/3/13) FITC

    sc-59872 FITC
    200 µg/ml
    		RMB2482.00

    CEACAM5 抗体 (26/3/13) PE

    sc-59872 PE
    200 µg/ml
    		RMB2580.00

    How can CEACAM5 (26/3/13): sc-59872 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

    Asked by: Professor Griffin
    In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-59872 PE) or fluoroscein (sc-59872 FITC).
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from CEACAM5 Antibody (26/3/13)Our lab finds this clone completely specific to CEACAM5 among cell surface displayed CEACAM1/3/5/6/7/8/20. (CEACAM4/16/19/21 not tested due to lower similarity). Detects rh CEACAM5 in ELISA and cell displayed CEACAM5 by flow cytometry. maximum MFI in flow titrations not as high as some other CEACAM5 antibodies, but EC50 is comparable. Originally part of genovac series. Epitope probably lies in N terminal IgV domain (based on binning, not confirmed)
    Date published: 2025-12-08
    Rated 4 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of CEACAM5 expression in LS1034 whole cell lysate under reducing and non-reducing conditions. -SCBT QC
    Date published: 2014-07-02
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    CEACAM5 抗体 (26/3/13) is rated 4.5 out of 5 by 2.
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