Date published: 2025-9-9

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Cdx2 抗体 (B-3): sc-166830

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说明书
  • Cdx2抗体(B-3)是小鼠单克隆IgG1 κ, 在8篇文献中引用,规格为200 µg/ml
  • 针对氨基酸271-313的抗原,在Cdx2的C-terminus处映射,human来源
  • 推荐用于 human 来源的Cdx2 WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRP是Cdx2 Antibody (B-3) for WB applications. 的首选辅助检测试剂,这些试剂现与Cdx2 Antibody (B-3) 打包提供(请参阅下面的订购信息)。

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関連項目

小鼠Cdx家族成员(Cdx1、Cdx2和Cdx4)是尾型同源盒基因家族的成员,它们是果蝇"尾部"基因的同源物,果蝇"尾部"基因对于前后区域同一性是必需的。肠特异性转录因子Cdx1和Cdx2是指导肠道发育、分化、增殖和维持肠道表型的候选基因。Cdx1与Cdx2蛋白的相对表达量对于肠道上皮的前后模式以及沿着隐窝-绒毛轴定义增殖和分化模式可能很重要。Cdx1同源盒基因在肠上皮细胞中的表达促进细胞生长和分化。Cdx1对其自身表达起正向调节作用。Cdx1和Cdx2在胎儿和成人的小肠和结肠中表达。人类Cdx1和/或Cdx2表达的减少与结直肠癌的发生有关。Cdx1和Cdx2基因都必须表达,以降低肿瘤发生潜力,增加对凋亡的敏感性,并减少细胞迁移,这表明这两个基因通过独立途径控制正常表型。人类Cdx1基因位于5号染色体长臂3区2带,编码一个由265个氨基酸组成的蛋白质。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdx2 抗体 (B-3) 参考文献:

  1. 肠道中的Cdx-1和Cdx-2同源框基因。  |  Freund, JN., et al. 1998. Biochem Cell Biol. 76: 957-69. PMID: 10392709
  2. CDX-2是胃肠道腺癌的新标志物。  |  Li, MK. and Folpe, AL. 2004. Adv Anat Pathol. 11: 101-5. PMID: 15090846
  3. Nkx6.2与Cdx-2协同刺激胰高血糖素原基因表达。  |  Wang, PX., et al. 2011. World J Diabetes. 2: 66-74. PMID: 21691557
  4. CDX2在炎症性肠病中的作用。  |  Coskun, M. 2014. Dan Med J. 61: B4820. PMID: 24814920
  5. CDX-2、MUC-2和B-catenin作为乳腺癌单纯粘液性癌的肠道标志物。  |  García-Labastida, L., et al. 2014. Biol Res. 47: 43. PMID: 25299496
  6. 原发性肺腺癌中的CDX-2表达。  |  Cowan, ML., et al. 2016. Appl Immunohistochem Mol Morphol. 24: 16-9. PMID: 26469326
  7. NKX2.2、PDX-1和CDX-2作为区分高分化神经内分泌肿瘤的潜在生物标志物。  |  Yang, MX., et al. 2018. Biomark Res. 6: 15. PMID: 29713473
  8. Wnt3a但不是CDX-2表达与分化型甲状腺癌有关。  |  Biagini, GLK., et al. 2022. Rev Assoc Med Bras (1992). 68: 400-404. PMID: 35442371
  9. CDX-2表达与接受免疫检查点抑制剂的MSI-H转移性结直肠癌患者的临床结果相关。  |  Ziranu, P., et al. 2023. Sci Rep. 13: 4397. PMID: 36928082
  10. KAT8介导的H4K16ac通过调节CDX2对维持滋养层细胞自我更新和增殖至关重要。  |  Bi, S., et al. 2024. Nat Commun. 15: 5602. PMID: 38961108

订购信息

产品名称产品编号规格价格数量收藏夹

Cdx2 抗体 (B-3)

sc-166830
200 µg/ml
RMB2377.00

Cdx2 (B-3): m-IgG Fc BP-HRP 套装

sc-540166
200 µg Ab; 10 µg BP
RMB2662.00

Cdx2 (B-3): m-IgG1 BP-HRP 套装

sc-541944
200 µg Ab; 20 µg BP
RMB2662.00

What is the recommended starting dilution for Western blot for sc-166830: Cdx2 (B-3) monoclonal antibody?

Asked by: AbPolly
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from wonderfull stainingCDX2 staining was evident in the nuclei of the epithelial cells throughout the intestine.
Date published: 2017-02-14
Rated 5 out of 5 by from Produced nice Western blot data of Cdx2 expressionProduced nice Western blot data of Cdx2 expression in COLO 320DM whole cell lysate. -SCBT QC
Date published: 2013-04-19
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Cdx2 抗体 (B-3) is rated 5.0 out of 5 by 2.
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