Date published: 2025-9-9

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CDw75/ST6GAL1 抗体 (ZB55): sc-20063

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说明书
  • CDw75/ST6GAL1抗体(ZB55)是小鼠单克隆IgM κ, 在1篇文献中引用,规格为200 µg/ml
  • 与CD32肽结合
  • 推荐用于 human 来源的CDw75 IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前,我们还没有完成CDw75/ST6GAL1 抗体 (ZB55)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

细胞表面糖蛋白和糖脂寡糖的修饰被认为在肿瘤发生和转移中起作用。唾液酸转移酶催化唾液酸掺入糖蛋白上的糖链,并在细胞内末端糖基化途径中发挥作用。一种这样的唾液酸转移酶CD75(也称为ST6GAL1)的表达导致细胞表面抗原CD76、HB-6和CDw75的出现。ST6GAL1在高尔基体中表达并分泌到细胞外液中,是一种II型膜蛋白,参与产生唾液酸化抗原,其功能是细胞表面糖决定因子。一种这样的抗原CDw75(也称为CD75s或CD75-sialyated)是通过将唾液酸残基从CD75催化转移到细胞表面含半乳糖的糖受体而形成的。虽然CD75在全身细胞中起作用,但CDw75主要存在于B细胞和T细胞中,在B细胞白血病中可能上调,表明CDw75可能在癌发生中起作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CDw75/ST6GAL1 抗体 (ZB55) 参考文献:

  1. ST6GAL1负调控单核细胞跨内皮迁移和动脉粥样硬化发展。  |  Zhang, J., et al. 2018. Biochem Biophys Res Commun. 500: 249-255. PMID: 29654763
  2. 血浆ST6GAL1通过调节IgG的唾液酸化来控制IgA肾病的进展。  |  Liu, Y., et al. 2021. Ther Adv Chronic Dis. 12: 20406223211048644. PMID: 34729155
  3. 细胞外的ST6GAL1可调节单核细胞-巨噬细胞的发育和存活。  |  Rusiniak, ME., et al. 2022. Glycobiology. 32: 701-711. PMID: 35661210
  4. 细胞外唾液酸化酶st6gal1对乳腺癌细胞的生长和侵袭性有影响。  |  Hait, NC., et al. 2022. Cancer Gene Ther. 29: 1662-1675. PMID: 35676533
  5. 血浆中的ST6Gal1对于IgG的唾液酸化是必需的。  |  Oswald, DM., et al. 2022. Glycobiology. 32: 803-813. PMID: 35746897
  6. ST6GAL1的下调可促进肝细胞炎症并预测肝细胞癌的不良预后。  |  Liu, R., et al. 2022. J Inflamm Res. 15: 5801-5814. PMID: 36238765
  7. ST6GAL1通过调节细胞表面MCAM的唾液酸化来抑制肝癌的转移。  |  Zou, X., et al. 2023. Oncogene. 42: 516-529. PMID: 36528750
  8. ST6GAL1唾液酸转移酶在调节卵巢癌细胞代谢中的作用。  |  Jones, RB., et al. 2023. Glycobiology. 33: 626-636. PMID: 37364046
  9. ST6GAL1对EGFR的唾液酸化可诱导受体活化并调节其运输动力学。  |  Ankenbauer, KE., et al. 2023. J Biol Chem. 299: 105217. PMID: 37660914
  10. ST6GAL1在甲状腺癌中的作用:组织分析和基因组数据集的见解。  |  Gunjača, I., et al. 2023. Int J Mol Sci. 24: PMID: 38003522

订购信息

产品名称产品编号规格价格数量收藏夹

CDw75/ST6GAL1 抗体 (ZB55)

sc-20063
200 µg/ml
RMB2377.00

CDw75/ST6GAL1 抗体 (ZB55) FITC

sc-20063 FITC
200 µg/ml
RMB2482.00

CDw75/ST6GAL1 抗体 (ZB55) PE

sc-20063 PE
200 µg/ml
RMB2580.00

How can CDw75 (ZB55): sc-20063 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Dr Ninau Qelp
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-20063 PE) or fluoroscein (sc-20063 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 4 out of 5 by from Good FCM data of NAMALWA cellsGood FCM data of NAMALWA cells. -SCBT QC
Date published: 2015-06-01
Rated 4 out of 5 by from Produced clear immunoperoxidase membraneProduced clear immunoperoxidase membrane staining in formalin fixed, paraffin-embedded human liver cancer. -SCBT QC
Date published: 2015-03-03
Rated 4 out of 5 by from Good indirect FCM data of BJAB cells stainedGood indirect FCM data of BJAB cells stained with CDw75 . -SCBT QC
Date published: 2014-10-18
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CDw75/ST6GAL1 抗体 (ZB55) is rated 4.0 out of 5 by 3.
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