Date published: 2026-10-24

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Cdk7 Antibody (MO-1) - Western Blotting - Image 380307
Cdk7 抗体 (MO-1): sc-56284. Jurkat (A), Caki-1 (B), RPMI2650 (C) 和 Y79 (D) 全细胞裂解液中 Cdk7 表达的 Western 印迹分析.
Cdk7 抗体 (MO-1): sc-56284. Jurkat (A), Caki-1 (B), RPMI2650 (C) 和 Y79 (D) 全细胞裂解液中 Cdk7 表达的 Western 印迹分析.

Cdk7 抗体 (MO-1): sc-56284

4.6(8)
寫評論提問
说明书
  • Cdk7抗体(MO-1)是小鼠单克隆IgG2b κ, 在8篇文献中引用，规格为200 µg/ml
  • 针对Cdk7的human起源的C-terminus的
  • 推荐用于 mouse, rat 和 human 来源的Cdk7 WB, IP, IF 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 Cdk7 (C-4): sc-7344，可查看有标记的 Cdk7 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是Cdk7 Antibody (MO-1) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Cdk7 Antibody (MO-1) 搭配使用（请参阅下面的订购信息）。
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関連項目

额外Cdk抗体，包括Cdk1, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8和Cdk9

细胞周期的进展需要激活一系列被称为细胞周期蛋白依赖性激酶（Cdks）的酶。单体催化亚基Cdk2是启动细胞周期进展的关键酶，但它是完全无活性的。通过结合调节性细胞周期蛋白（如细胞周期蛋白D1）可以实现部分激活，而完全激活则需要在Thr 160上进行额外的磷酸化。负责在Thr 160上磷酸化Cdk2以及在Thr 161上磷酸化Cdc2 p34的酶被称为Cdk激活激酶（CAK），该酶已被部分纯化，并显示由催化亚基和调节亚基组成。催化亚基被命名为Cdk7，已被鉴定为MO15的哺乳动物同源物，MO15是在海星和非洲爪蟾中表现的一种蛋白激酶。调节亚基是一种新型细胞周期蛋白（细胞周期蛋白H），是激活Cdk7所必需的。与其他Cdks一样，Cdk7包含一个保守的苏氨酸残基，该残基对于其完全活性是必需的；该残基的突变会严重降低CAK的活性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk7 抗体 (MO-1) 参考文献:

  1. 用共价CDK7抑制剂靶向癌症中的转录调控。  |  Kwiatkowski, N., et al. 2014. Nature. 511: 616-20. PMID: 25043025
  2. 小分子化合物在临床前模型中联合靶向CKIα和转录激酶CDK7/9控制急性髓细胞白血病。  |  Minzel, W., et al. 2018. Cell. 175: 171-185.e25. PMID: 30146162
  3. CDK7 抑制可增强基因组不稳定性，触发小细胞肺癌的抗肿瘤免疫。  |  Zhang, H., et al. 2020. Cancer Cell. 37: 37-54.e9. PMID: 31883968
  4. 通过CDK7抑制饥饿多发性骨髓瘤细胞。  |  Sacco, A. and Roccaro, AM. 2023. Blood. 141: 2787-2788. PMID: 37289477
  5. CDK7抑制剂samuraciclib一期研究中晚期乳腺癌患者的剂量递增和扩展队列。  |  Coombes, RC., et al. 2023. Nat Commun. 14: 4444. PMID: 37488191
  6. 新型共价CDK7抑制剂可有效诱导急性髓细胞性白血病细胞凋亡，并与Venetoclax协同作用。  |  Gaur, T., et al. 2023. J Exp Clin Cancer Res. 42: 186. PMID: 37507802
  7. CDK7和CDK9抑制干扰转录、翻译和干细胞，并诱导GBM的细胞毒性，而与替莫唑胺的敏感性无关。  |  Bhutada, I., et al. 2024. Neuro Oncol. 26: 70-84. PMID: 37551745
  8. 活跃的生长信号促进衰老和癌细胞对CDK7抑制的敏感性。  |  Wilson, GA., et al. 2023. Mol Cell. 83: 4078-4092.e6. PMID: 37977119
  9. 选择性CDK7抑制可抑制细胞周期进展和MYC信号传导，同时增强对雌激素受体阳性乳腺癌的抗药性。  |  Guarducci, C., et al. 2024. Clin Cancer Res. 30: 1889-1905. PMID: 38381406
  10. 双T环磷酸化激活Cdk7的结构基础。  |  Düster, R., et al. 2024. Nat Commun. 15: 6597. PMID: 39097586

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk7 抗体 (MO-1)

sc-56284
200 µg/ml
CNY2422.00

Cdk7 (MO-1): m-IgG Fc BP-HRP 套装

sc-551938
200 µg Ab; 10 µg BP
CNY2715.00

Cdk7 抗体 (MO-1) FITC

sc-56284 FITC
200 µg/ml
CNY2527.00

Cdk7 抗体 (MO-1) PE

sc-56284 PE
200 µg/ml
CNY2625.00

How can Cdk7 (MO-1): sc-56284 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Germaine
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-56284 PE) or fluoroscein (sc-56284 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by my223 from Goof for WB and IPIt is good for Western blot and IP with human cell nuclear extract.
Date published: 2018-02-04
Rated 5 out of 5 by Helena123 from Good resultWe use it for IF applications and got good result.
Date published: 2016-12-02
Rated 5 out of 5 by caca from Good specificityGood specificity, it is suitable for my current experimental study, unexpected results
Date published: 2016-11-23
Rated 5 out of 5 by mengfanchang from Good specificityGood specificity and signal strength for WB in NIH/3T3 and K-562 whole cell lysates. -SCBT QGood specificity and signal strength for WB in NIH/3T3 and K-562 whole cell lysates. -SCBT QCC
Date published: 2016-11-05
Rated 4 out of 5 by AB from Works well for IF applicationsWorks well for IF applications, positive in HeLa. -SCBT QC
Date published: 2015-04-01
Rated 5 out of 5 by CJ from WB positive with SW480 cellsWB positive with SW480 cells. -SCBT Publication Review
Date published: 2015-02-26
Rated 4 out of 5 by LR from Worked with transfected lysate by WBWorked with transfected lysate by WB -SCBT QC
Date published: 2015-02-05
Rated 4 out of 5 by MS from Good specificity and signal strength forGood specificity and signal strength for WB in NIH/3T3 and K-562 whole cell lysates. -SCBT QC
Date published: 2014-07-16
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Cdk7 抗体 (MO-1) is rated 4.6 out of 5 by 8.
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