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Cdk7 抗体 (D-5): sc-271794

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说明书
  • Cdk7抗体(D-5)是小鼠单克隆IgG2b (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的Cdk7的C-terminus的氨基酸317-346之间
  • 推荐用于 mouse, rat 和 human 来源的Cdk7 WB, IP, IF 和 ELISA检测; 也和以下物种反应,包括: 和 equine, bovine and porcine
  • 看 Cdk7 (C-4): sc-7344,可查看有标记的 Cdk7 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 2b BP-HRP">m-IgG2b BP-HRP是Cdk7 Antibody (D-5) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现与Cdk7 Antibody (D-5) 打包提供(请参阅下面的订购信息)。
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    细胞周期的进展需要激活一系列被称为细胞周期蛋白依赖性激酶(Cdks)的酶。单体催化亚基Cdk2是启动细胞周期进展的关键酶,但它是完全无活性的。通过结合调节性细胞周期蛋白(如细胞周期蛋白D1)可以实现部分激活,而完全激活则需要在Thr 160上进行额外的磷酸化。负责在Thr 160上磷酸化Cdk2以及在Thr 161上磷酸化Cdc2 p34的酶被称为Cdk激活激酶(CAK),该酶已被部分纯化,并显示由催化亚基和调节亚基组成。催化亚基被命名为Cdk7,已被鉴定为MO15的哺乳动物同源物,MO15是在海星和非洲爪蟾中表现的一种蛋白激酶。调节亚基是一种新型细胞周期蛋白(细胞周期蛋白H),是激活Cdk7所必需的。与其他Cdks一样,Cdk7包含一个保守的苏氨酸残基,该残基对于其完全活性是必需的;该残基的突变会严重降低CAK的活性。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Cdk7 抗体 (D-5) 参考文献:

    1. Cdk7:转录核心中的激酶,癌症药物研发的焦点。  |  Fisher, RP. 2019. Transcription. 10: 47-56. PMID: 30488763
    2. CDK7抑制剂的癌症免疫疗法。  |  Petroni, G. and Galluzzi, L. 2020. Trends Cancer. 6: 361-363. PMID: 32348731
    3. 骨和软组织肉瘤中CDK7依赖性转录依赖:现状与未来。  |  Yuan, J., et al. 2022. Biochim Biophys Acta Rev Cancer. 1877: 188680. PMID: 35051528
    4. CDK7抑制剂可增强胰腺癌对多药化疗的反应。  |  Zeng, S., et al. 2022. J Exp Clin Cancer Res. 41: 241. PMID: 35945614
    5. CDK7/GRP78信号轴促进骨肉瘤的肿瘤生长和转移。  |  Zhang, T., et al. 2022. Oncogene. 41: 4524-4536. PMID: 36042349
    6. CDK7抑制剂对MYCN扩增视网膜母细胞瘤的影响。  |  Xu, H., et al. 2023. Biochim Biophys Acta Gene Regul Mech. 1866: 194964. PMID: 37536559
    7. 联合靶向HSP90α和CDK7克服了BCR-ABL1+白血病细胞对HSP90抑制剂的耐药性。  |  Vogt, M., et al. 2023. Cell Death Dis. 14: 799. PMID: 38057328
    8. 乳腺癌中的CDK7:作用机制和治疗潜力。  |  Gong, Y. and Li, H. 2024. Cell Commun Signal. 22: 226. PMID: 38605321
    9. CDK7 激酶活性通过促进起始因子释放来促进 RNA 聚合酶 II 启动子逃避。  |  Velychko, T., et al. 2024. Mol Cell. 84: 2287-2303.e10. PMID: 38821049
    10. 发现细胞周期蛋白依赖性激酶7(CDK7)的双价小分子降解剂。  |  Ji, W., et al. 2024. Eur J Med Chem. 276: 116613. PMID: 39004018

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Cdk7 抗体 (D-5)

    sc-271794
    200 µg/ml
    CNY2422.00

    Cdk7 (D-5): m-IgG2b BP-HRP 套装

    sc-548543
    200 µg Ab; 10 µg BP
    CNY2715.00

    Cdk7 (D-5) 中和勝肽

    sc-271794 P
    100 µg/0.5 ml
    CNY519.00

    What application is the blocking peptide sc-271794 P appropriate for?

    Asked by: TinTin
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by SF from Works well for IF applicationsWorks well for IF applications, positive in HeLa. -SCBT QC
    Date published: 2015-04-10
    Rated 3 out of 5 by HF from Worked with transfected lysate by WB withWorked with transfected lysate by WB with some background -SCBT QC
    Date published: 2014-04-14
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    Cdk7抗体 (D-5) is rated 4.0 out of 5 by 2.
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