Date published: 2026-10-20

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Cdk6 Antibody (DCS-83) - Western Blotting - Image 352057
Cdk6 抗体 (DCS-83): sc-53638. HeLa (A), NIH/3T3 (B), C6 (C), NCI-H460 (D), Raji (E) 和 SCC-4 (F) 全细胞裂解液中 Cdk6 表达的 Western 印迹分析.
Cdk6 抗体 (DCS-83): sc-53638. HeLa (A), NIH/3T3 (B), C6 (C), NCI-H460 (D), Raji (E) 和 SCC-4 (F) 全细胞裂解液中 Cdk6 表达的 Western 印迹分析.

Cdk6 抗体 (DCS-83): sc-53638

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寫評論提問
说明书
  • Cdk6抗体(DCS-83)是小鼠单克隆IgG1 κ, 在20篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Cdk6的氨基酸30-65
  • 抗-Cdk6 抗体 (DCS-83) 推荐用于 WB, IP 和 IF，检测mouse, rat 和human 来源的 Cdk6
  • 抗Cdk6抗体（DCS-83）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgGκ BP-HRP是Cdk6 Antibody (DCS-83) 适用于 WB 应用。 的首选辅助检测试剂。该试剂现可与Cdk6 Antibody (DCS-83) 搭配使用（请参阅下面的订购信息）。有关其它 m-IgGκ BP 结合物，请参阅我们完整的小鼠 IgG 结合蛋白列表。
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描述
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関連項目

额外Cdk抗体，包括Cdk1, Cdk11, Cdk2, Cdk3, Cdk4, Cdk5, Cdk6, Cdk7, Cdk8和Cdk9

Cdk6 抗体（DCS-83）是一种小鼠单克隆 IgG1 kappa 轻链抗体，可通过免疫印迹（WB）、免疫沉淀（IP）和免疫荧光（IF）检测小鼠、大鼠和人源的 Cdk6。抗 Cdk6 抗体（DCS-83）有非共轭型和多种共轭型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种 Alexa Fluor® 共轭物。Cdk6 与细胞周期蛋白 D1、D2 和 D3 合作，使细胞周期进展所必需的目标底物磷酸化，从而在细胞周期调控中，尤其是在 G1/S 过渡中发挥着至关重要的作用。Cdk6 与这些细胞周期蛋白相互作用的能力至关重要，因为这种相互作用能确保细胞分裂的正确时间，防止不受控制的增殖，而这正是癌症的特征。此外，p18 和 p19 等特异性抑制剂通过与游离和与细胞周期蛋白结合的形式结合来调节 Cdk6，从而调节其活性并维持细胞的平衡。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk6 抗体 (DCS-83) 参考文献:

  1. 淋巴恶性肿瘤中的CDK6和p16INK4A。  |  Kollmann, K. and Sexl, V. 2013. Oncotarget. 4: 1858-9. PMID: 24161991
  2. CDK6--回顾过去，展望未来：从细胞周期控制到转录调控。  |  Tigan, AS., et al. 2016. Oncogene. 35: 3083-91. PMID: 26500059
  3. 乳腺癌中CDK4和CDK6的抑制--新标准。  |  Wolff, AC. 2016. N Engl J Med. 375: 1993-1994. PMID: 27959592
  4. CDK6 在肿瘤发生过程中拮抗 p53 诱导的反应  |  Bellutti, F., et al. 2018. Cancer Discov. 8: 884-897. PMID: 29899063
  5. 靶向Ph+急性淋巴细胞白血病的CDK6依赖性。  |  Porazzi, P., et al. 2021. Genes (Basel). 12: PMID: 34573335
  6. CDK6降解在急性髓细胞白血病中被p16INK4A和p18INK4C抵消  |  Schmalzbauer, BS., et al. 2022. Cancers (Basel). 14: PMID: 35326705
  7. E2F1-HOXB9/PBX2-CDK6轴驱动胃癌发生，并作为胃癌的治疗靶点。  |  Zhang, J., et al. 2023. J Pathol. 260: 402-416. PMID: 37272544
  8. CDK6是一种新型预测和预后生物标志物，与多种人类肿瘤（包括小细胞肺癌）中的免疫浸润相关。  |  Li, GS., et al. 2023. Funct Integr Genomics. 23: 332. PMID: 37950078
  9. CDK6抑制白色脂肪组织中从头合成脂质，但不抑制肝脏中的脂质合成。  |  Hu, AJ., et al. 2024. Nat Commun. 15: 1091. PMID: 38316780
  10. 激酶失活的CDK6可保持成人造血干细胞的长期功能。  |  Mayer, IM., et al. 2024. Blood. 144: 156-170. PMID: 38684032

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk6 抗体 (DCS-83)

sc-53638
200 µg/ml
CNY2422.00

Cdk6 (DCS-83): m-IgGκ BP-HRP 套装

sc-551066
200 µg Ab; 40 µg BP
CNY2715.00

Cdk6 抗体 (DCS-83) AC

sc-53638 AC
500 µg/ml, 25% agarose
CNY3189.00

Cdk6 抗体 (DCS-83) HRP

sc-53638 HRP
200 µg/ml
CNY2422.00

Cdk6 抗体 (DCS-83) FITC

sc-53638 FITC
200 µg/ml
CNY2527.00

Cdk6 抗体 (DCS-83) PE

sc-53638 PE
200 µg/ml
CNY2625.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 488

sc-53638 AF488
200 µg/ml
CNY2738.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 546

sc-53638 AF546
200 µg/ml
CNY2738.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 594

sc-53638 AF594
200 µg/ml
CNY2738.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 647

sc-53638 AF647
200 µg/ml
CNY2738.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 680

sc-53638 AF680
200 µg/ml
CNY2738.00

Cdk6 抗体 (DCS-83) Alexa Fluor® 790

sc-53638 AF790
200 µg/ml
CNY2738.00

Can Cdk6 (DCS-83): sc-53638 monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: jenniferc
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. Cdk6 (DCS-83): sc-53638 is available conjugated to agarose (sc-53638 AC), 500 µg/0.25 ml agarose in 1 ml, for IP; HRP (sc-53638 HRP), 200 µg/ml, for WB, IHC(P) and ELISA; phycoerythrin (sc-53638 PE), fluorescein (sc-53638 FITC), Alexa Fluor® 488 (sc-53638 AF488) or Alexa Fluor® 647 (sc-53638 AF647), 200 µg/ml, for IF, IHC(P) and FCM
Answered by: Technical Support 15
Date published: 2017-01-19
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Rated 5 out of 5 by Haitao from Great antibody for IB!This antibody works great for IB of mouse cells. CST has same clone but more expensive compared to this one!
Date published: 2017-11-28
Rated 1 out of 5 by Just15 from Didnot work for WBDid not work for western blot - sc-7961 was better
Date published: 2017-11-21
Rated 5 out of 5 by NEW LCRC from WORK ot IBFor my experment, I just detected the purified protein. It is work.
Date published: 2017-07-10
Rated 5 out of 5 by Bill28 from Outstanding WBVery nice western blot data; strong signal with low background !!
Date published: 2017-02-02
Rated 5 out of 5 by jerojero from Excellent!This antibody works great in western blot analysis of Cdk6 expression in HeLa, NIH/3T3, C6, NCI-H460, Raji and SCC-4 whole cell lysates.
Date published: 2017-01-11
Rated 5 out of 5 by Cena from We used this antibody in WB in mouse cellsWe used this antibody in WB in mouse cells, got correct band at 1:500 dilution.
Date published: 2015-09-10
Rated 5 out of 5 by LR from The antibody works well for Western blottingThe antibody works well for Western blotting detecting endogenous Cdk6 from Jurkat cells. -SCBT QC
Date published: 2015-04-01
Rated 5 out of 5 by LF from Publishable Western blot and IP data usingPublishable Western blot and IP data using mouse Ada3FL/FL MEFs -SCBT Publication Review
Date published: 2015-03-26
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Cdk6 抗体 (DCS-83) is rated 4.6 out of 5 by 9.
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