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Cdk4 抗体 (0.N.199): sc-70832

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说明书
  • Cdk4抗体(0.N.199)是小鼠单克隆IgG1 κ, 在16篇文献中引用,规格为200 µg/ml
  • 针对全长重组的human Cdk4
  • 推荐用于 mouse, rat 和 human 来源的Cdk4 WB, IP, IF 和 IHC(P)检测
  • 看 Cdk4 (DCS-35): sc-23896,可查看有标记的 Cdk4 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP是Cdk4 Antibody (0.N.199) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与Cdk4 Antibody (0.N.199) 搭配使用(请参阅下面的订购信息)。
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Cdk4抗体(0.N.199)是一种小鼠单克隆IgG1 kappa轻链抗体,用于检测小鼠、大鼠和人类样本中的细胞周期蛋白依赖性激酶4(Cdk4),也称为CDC2样激酶4。Anti-Cdk4抗体(0.N.199)可靶向全长重组人Cdk4蛋白,非常适合用于蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和石蜡包埋切片免疫组织化学(IHCP)等应用。Cdk4是一种重要的丝氨酸/苏氨酸激酶,通过与D型细胞周期蛋白形成复合物,在调节细胞周期(尤其是从G1期到S期的过渡)中发挥着重要作用。这些复合物对包括视网膜母细胞瘤蛋白(Rb)在内的关键底物进行磷酸化,从而促进细胞周期的进展和细胞增殖。Cdk4的功能对于正常细胞生长和分裂至关重要,失调通常与各种癌症有关,因此Cdk4成为癌症研究和治疗开发的重要目标。通过与细胞周期蛋白相互作用,Cdk4的活性得以调节,从而确保细胞周期进展得到控制,而p16等抑制剂则可以下调Cdk4的活性,防止细胞无序分裂。了解Cdk4的功能有助于深入了解细胞增殖的机理,以及开发靶向癌症疗法的潜力。Cdk4 (0.N.199)抗体有非结合型和多种结合型,包括辣根过氧化物酶(HRP)和荧光标记,具有多功能性,能够满足不同的研究需求。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdk4 抗体 (0.N.199) 参考文献:

  1. Cdk4通过激活PPARγ促进脂肪生成。  |  Abella, A., et al. 2005. Cell Metab. 2: 239-49. PMID: 16213226
  2. 胰腺内分泌肿瘤中细胞周期依赖性激酶4(CDK4)的表达。  |  Lindberg, D., et al. 2007. Neuroendocrinology. 86: 112-8. PMID: 17664862
  3. CDK4 磷酸化 AMPKα2 以抑制其活性并抑制脂肪酸氧化。  |  Lopez-Mejia, IC., et al. 2017. Mol Cell. 68: 336-349.e6. PMID: 29053957
  4. 乳腺癌细胞周期依赖性激酶4/6(CDK4/6)抑制剂治疗期间不良事件的管理。  |  Thill, M. and Schmidt, M. 2018. Ther Adv Med Oncol. 10: 1758835918793326. PMID: 30202447
  5. CDK4过度表达是骨肉瘤患者对常规化疗产生抗性的预测性生物标志物。  |  Iwata, S., et al. 2021. Oncol Rep. 46: PMID: 34036394
  6. 人类癌细胞系中CDK4和CDK6基因依赖性的功能基因组分析。  |  Zhang, Z., et al. 2022. Cancer Res. 82: 2171-2184. PMID: 35395071
  7. 软组织肿瘤中p16和CDK4的免疫组织化学表达。  |  Sagar, M., et al. 2023. Cureus. 15: e35713. PMID: 37016649
  8. Cdk4点突变小鼠的免疫表型。  |  Yabas, M. and Hoyne, GF. 2023. Biomedicines. 11: PMID: 37893220
  9. CDK4作为肝细胞癌的预后标志物和CDK4抑制剂作为潜在治疗药物。  |  Lai, F., et al. 2024. Curr Med Chem.. PMID: 38231074
  10. 在转化生长因子-β诱导的G1细胞周期阻滞中,p53依赖性抑制cdk4合成。  |  Ewen, ME. 1996. J Lab Clin Med. 128: 355-60. PMID: 8833883

订购信息

产品名称产品编号规格价格数量收藏夹

Cdk4 抗体 (0.N.199)

sc-70832
200 µg/ml
CNY2422.00

Cdk4 (0.N.199): m-IgG Fc BP-HRP 套装

sc-551964
200 µg Ab; 10 µg BP
CNY2715.00

Can Cdk4 (0.N.199): sc-70832 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Cweed
Thank you for your question. Yes, Cdk4 (0.N.199): sc-70832 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
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Rated 5 out of 5 by LF from Publishable Western blot results using HepG2Publishable Western blot results using HepG2, HHCC, SMMC7721, QZG and AD-293 cell lines -SCBT Publication Review
Date published: 2015-04-13
Rated 4 out of 5 by SS from Good specificity and signal strength withGood specificity and signal strength with HeLa and Ramos. Some background bands -SCBT QC
Date published: 2015-01-30
Rated 5 out of 5 by CJ from Worked with transfected lysate by WBWorked with transfected lysate by WB -SCBT QC
Date published: 2014-03-14
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Cdk4 抗体 (0.N.199) is rated 4.7 out of 5 by 3.
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