Date published: 2025-9-7
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Cdc37 Antibody (C-11) - Western Blotting - Image 609
Cdc37 抗体 (C-11): sc-17758. Western 印迹分析 Jurkat (A) 和 K-562 (B) 全细胞裂解液中 Cdc37 的表达.
Cdc37 抗体 (C-11): sc-17758. Western 印迹分析 Jurkat (A) 和 K-562 (B) 全细胞裂解液中 Cdc37 的表达.

Cdc37 抗体 (C-11): sc-17758

5.0(5)
寫評論提問

说明书
  • Cdc37抗体(C-11)是小鼠单克隆IgG2b κ, 在9篇文献中引用，规格为200 µg/ml
  • 免疫human物种的Cdc37的氨基酸108-378
  • 推荐用于 human 来源的Cdc37 WB, IP, IF, IHC(P) 和 ELISA检测
  • 目前，我们还没有完成Cdc37 抗体 (C-11)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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相关产品
描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Cdc 抗体 包括 Cdc11, Cdc123, Cdc13, Cdc14 Phosphatase, Cdc16, Cdc2, Cdc20B, Cdc25, Cdc26和Cdc27

细胞周期事件受到细胞周期蛋白依赖性激酶（Cdks）的顺序激活和失活以及细胞周期蛋白的蛋白水解的调节。细胞分裂周期（Cdc）基因在细胞周期的不同阶段都是必需的。Cdc25A、Cdc25B和Cdc25C蛋白酪氨酸磷酸酶通过去磷酸化调节性酪氨酸残基上的Cdc2 p34来发挥有丝分裂激活剂的作用。Cdc6是酿酒酵母Cdc6的人类同源物，参与DNA复制的启动。Cdc37似乎促进Cdk4/cyclin D1复合物的形成，并已显示与Hsp90形成稳定的复合物。Cdc34、Cdc27和Cdc16作为泛素结合酶发挥作用。Cdc34被认为是酿酒酵母Cdc34的结构和功能同源物，对于G1期到S期的转变至关重要。Cdc16和Cdc27是APC（后期促进复合物）的组成部分，该复合物使细胞周期蛋白B泛素化，导致细胞周期蛋白B/Cdk复合物的降解。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Cdc37 抗体 (C-11) 参考文献:

  1. 限制 CDC37 与 HSP90 的直接相互作用不会影响客户蛋白的伴侣作用。  |  Smith, JR., et al. 2015. Oncogene. 34: 15-26. PMID: 24292678
  2. Hsp90 和 Cdc37 如何润滑激酶分子开关  |  Verba, KA. and Agard, DA. 2017. Trends Biochem Sci. 42: 799-811. PMID: 28784328
  3. 以Hsp90-Cdc37-客户蛋白相互作用为目标，破坏Hsp90伴侣机制。  |  Li, T., et al. 2018. J Hematol Oncol. 11: 59. PMID: 29699578
  4. 针对结直肠癌中 Hsp90-Cdc37 蛋白-蛋白相互作用的小分子抑制剂。  |  Wang, L., et al. 2019. Sci Adv. 5: eaax2277. PMID: 31555737
  5. 神经退行性疾病中 Hsp90/Cdc37 相互作用的治疗潜力  |  Gracia, L., et al. 2019. Front Neurosci. 13: 1263. PMID: 31824256
  6. 靶向 HSP90-CDC37 激酶伴侣循环：一种前景广阔的癌症治疗策略  |  Wang, L., et al. 2022. Med Res Rev. 42: 156-182. PMID: 33846988
  7. 硫氧化还原蛋白-1通过靶向帕金森病中的Hsp90/p-Cdc37伴侣复合物抑制IRE1的激活。  |  Zeng, X., et al. 2023. Ageing Res Rev. 90: 102000. PMID: 37437766
  8. 人参皂苷Rg5通过减少HSP90-CDC37相互作用和促进客户蛋白降解来增强肺腺癌的放射敏感性。  |  Bai, H., et al. 2023. J Pharm Anal. 13: 1296-1308. PMID: 38174116
  9. RAF1-HSP90-CDC37 和 HSP90 复合物的结构动力学揭示了不对称的客户相互作用和关键结构元素。  |  Finci, LI., et al. 2024. Commun Biol. 7: 260. PMID: 38431713
  10. 异构 CDC37 抑制剂破坏伴侣复合物以阻止 CDK4/6 成熟  |  Zhang, L., et al. 2025. Angew Chem Int Ed Engl. 64: e202413618. PMID: 39582167

订购信息

产品名称产品编号规格价格数量收藏夹

Cdc37 抗体 (C-11)

sc-17758
200 µg/ml
RMB2377.00

I am using Cdc37 (C-11): sc-17758 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Cweed
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Funziona sia per WB che IFanticorpo anti cdc37 lavora benissimo sia in IF (1:300) che per WB (1:1000). In entrambe le tipologie di saggio, ottimo signal/noise ratio
Date published: 2025-07-13
Rated 5 out of 5 by from Strong cytoplasmic localization in IF in methanolStrong cytoplasmic localization in IF in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-03-13
Rated 5 out of 5 by from Worked well in IP and WB in HEK293 and RT112Worked well in IP and WB in HEK293 and RT112 cells. -SCBT Publication Review
Date published: 2015-03-01
Rated 5 out of 5 by from Good specificity in WB in Jurkat and KGood specificity in WB in Jurkat and K-562 whole cell lysates. -SCBT QC
Date published: 2015-02-13
Rated 5 out of 5 by from Good antibody for formalin fixed human duodenumGood antibody for formalin fixed human duodenum tissue showing cytoplasmic and membrane staining in IHC. -SCBT QC
Date published: 2015-01-31
Rated 5 out of 5 by from Good WB antibdy in COS7 transfected with wildGood WB antibdy in COS7 transfected with wild-type PINK1-FLAG or L347P mutant PINK1-FLAG. -SCBT Publication Review
Date published: 2013-02-28
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Cdc37 抗体 (C-11) is rated 5.0 out of 5 by 6.
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