Date published: 2025-9-6
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CD79B Antibody (AT107-2) - Western Blotting - Image 381094
CD79B 抗体 (AT107-2): sc-59115. 拉莫斯 (A) 和 NAMALWA (B) 全细胞裂解液以及大鼠淋巴结 (C) 和小鼠脾脏 (D) 组织提取物中 CD79B 表达的 Western 印迹分析.
CD79B 抗体 (AT107-2): sc-59115. 拉莫斯 (A) 和 NAMALWA (B) 全细胞裂解液以及大鼠淋巴结 (C) 和小鼠脾脏 (D) 组织提取物中 CD79B 表达的 Western 印迹分析.

CD79B 抗体 (AT107-2): sc-59115

5.0(7)
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说明书
  • CD79B 抗体 AT107-2 是大鼠单克隆 IgG1, 在1篇文献中引用，提供 200 µg/ml
  • 针对CD79B的细胞内区域，human来源
  • 推荐用于 mouse, rat 和 human 来源的an intracellular region of human CD79B WB, IP 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 目前，我们还没有完成CD79B 抗体 (AT107-2)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CD79 抗体 包括 CD79B

CD79（也称为Igα/Igβ）是一种由α链（称为CD79A或MB-1）和β链（称为CD79B或B29）组成的异二聚体。B细胞抗原受体复合物（BCR）是由CD79与膜免疫球蛋白（如IgM或IgD）结合形成的。IgM和IgD膜免疫球蛋白在CD79结合的作用下实现表面表达和抗原呈递功能。CD79A和CD79B的细胞质尾部均含有ITAM（免疫受体酪氨酸基激活）基序，它通过结合和激活酪氨酸激酶来启动BCR信号反应。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD79B 抗体 (AT107-2) 参考文献:

  1. 成熟 B 细胞淋巴细胞增生性疾病中 CD79b、CD5 和 CD19 的定量分析。  |  Cabezudo, E., et al. 1999. Haematologica. 84: 413-8. PMID: 10329919
  2. 布鲁顿酪氨酸激酶是 CD79b 介导的前 B 细胞向前 B 细胞转化的信号传递所必需的。  |  Kouro, T., et al. 2001. Int Immunol. 13: 485-93. PMID: 11282988
  3. B 细胞慢性淋巴细胞白血病 (B-CLL) 细胞中 B 细胞受体成分的异质性胞内表达以及 CD79b 基因转移对 B-CLL 衍生细胞系表面免疫球蛋白水平的影响。  |  Minuzzo, S., et al. 2005. Br J Haematol. 130: 878-89. PMID: 16156858
  4. 用抗体和抗体药物共轭物靶向 CD79b 的体内效应。  |  Zheng, B., et al. 2009. Mol Cancer Ther. 8: 2937-46. PMID: 19808977
  5. 由于 CD79b 的异常表达，以 TCR 为基础的 BCR 相关蛋白 CD79b 靶向治疗受到了阻碍。  |  Jahn, L., et al. 2015. Blood. 125: 949-58. PMID: 25414443
  6. CD79B和MYD88的突变频率在原发性睾丸DLBCL和胃肠道DLBCL之间差异很大。  |  Frick, M., et al. 2018. Leuk Lymphoma. 59: 1260-1263. PMID: 28868954
  7. 血管内大 B 细胞淋巴瘤中 MYD88 和 CD79B 基因突变的高发率。  |  Schrader, AMR., et al. 2018. Blood. 131: 2086-2089. PMID: 29514783
  8. 脑龙结合布鲁顿酪氨酸激酶 (BTK) 降解剂 CD79b 靶向抗体-药物共轭物的设计、合成、体外和体内评估。  |  Zhang, A., et al. 2024. Bioconjug Chem. 35: 140-146. PMID: 38265691
  9. 用于治疗非霍奇金淋巴瘤的三种新型 CD79b 靶向 CAR 的临床前开发以及靶抗原丢失的特征描述。  |  Esquinas, E., et al. 2024. J Immunother Cancer. 12: PMID: 39694704
  10. 急性淋巴细胞白血病中 B29（CD79b）和 mb-1（CD79a）蛋白的差异表达。  |  Astsaturov, IA., et al. 1996. Leukemia. 10: 769-73. PMID: 8656670

订购信息

产品名称产品编号规格价格数量收藏夹

CD79B 抗体 (AT107-2)

sc-59115
200 µg/ml
RMB2377.00

CD79B 抗体 (AT107-2) FITC

sc-59115 FITC
200 µg/ml
RMB2482.00

CD79B 抗体 (AT107-2) PE

sc-59115 PE
200 µg/ml
RMB2580.00

How can CD79B (AT107-2): sc-59115 mouse monoclonal antibody be used for double or triple staining, if the other primary antibodies are also raised in mouse?

Asked by: Randy McDonald
In this case, we recommend using a directly conjugated mouse monoclonal primary antibody. This antibody is available conjugated to phycoerythrin (sc-59115 PE) or fluoroscein (sc-59115 FITC).
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Robust signal in WB in human transfectedRobust signal in WB in human transfected 293T and Raji whole cell lysates. -SCBT QC
Date published: 2015-06-19
Rated 5 out of 5 by from Good signal strength in WB in mouse transfectedGood signal strength in WB in mouse transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-05-15
Rated 5 out of 5 by from Positive signal in WB in Daudi whole cell lysatePositive signal in WB in Daudi whole cell lysate. -SCBT QC
Date published: 2015-04-19
Rated 5 out of 5 by from Worked well in WB in Ramos whole cell lysateWorked well in WB in Ramos whole cell lysate. -SCBT QC
Date published: 2015-03-14
Rated 5 out of 5 by from Good specificity in WB in BYDP whole cell lysateGood specificity in WB in BYDP whole cell lysate. -SCBT QC
Date published: 2015-01-27
Rated 5 out of 5 by from Strong band in WB in Ramos and Daudi wholeStrong band in WB in Ramos and Daudi whole cell lysates. -SCBT QC
Date published: 2015-01-24
Rated 5 out of 5 by from Good publishable data in WB in mice boneGood publishable data in WB in mice bone marrow cells. -SCBT Publication Review
Date published: 2013-11-27
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CD79B 抗体 (AT107-2) is rated 5.0 out of 5 by 7.
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