Date published: 2025-9-6
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CD79A Antibody (HM47) - Western Blotting - Image 160856
CD79A 抗体 (HM47): sc-20064. 对 Raji 全细胞裂解液中 CD79A 表达的 Western 印迹分析.
CD79A 抗体 (HM47): sc-20064. 对 Raji 全细胞裂解液中 CD79A 表达的 Western 印迹分析.

CD79A 抗体 (HM47): sc-20064

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说明书
  • CD79A 抗体 HM47 是小鼠单克隆 IgG1 κ，CD79A抗体, 在22篇文献中引用，规格为200 µg/ml
  • 针对human肽的抗体
  • CD79A 抗体 (HM47) 推荐用于 WB, IP, IF, IHC(P) 和 FCM，检测mouse, rat 和human 来源的 CD79A
  • 抗CD79A抗体（HM47）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CD79A (HM47): sc-20064的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 CD79A 抗体 (HM47) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CD79A 抗体 (HM47) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CD79 抗体 包括 CD79B

CD79A抗体（HM47）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）、石蜡包埋切片免疫组织化学（IHCP）和流式细胞术（FCM）检测小鼠、大鼠和人类来源的CD79A蛋白。CD79A (HM47) 抗体有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶 (HRP)、藻红蛋白 (PE)、异硫氰酸荧光素 (FITC) 和多种 Alexa Fluor® 结合型。CD79A蛋白，也称为免疫球蛋白相关α链，在B细胞抗原受体（BCR）复合物中起着至关重要的作用，而BCR复合物对于B细胞活化和免疫反应至关重要。CD79A位于B细胞表面，与CD79B形成异二聚体，促进与膜免疫球蛋白（如IgM和IgD）的结合。这种相互作用对于抗原识别后B细胞的正常信号传导和激活至关重要，因为CD79A和CD79B的细胞质尾部含有免疫受体酪氨酸基激活基序（ITAM），可招募和激活酪氨酸激酶，从而引发下游信号级联。CD79A能够调节这些关键过程，这凸显了CD79A在适应性免疫反应中的重要性，使得抗CD79A抗体（HM47）成为研究B细胞生物学和相关免疫学途径的宝贵工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD79A 抗体 (HM47) 参考文献:

  1. 在人类 B 细胞分化过程中，B29 和 mb-1 多肽的表达存在差异。  |  Mason, DY., et al. 1992. Eur J Immunol. 22: 2753-6. PMID: 1396979
  2. 与鼠mb-1基因同源的人类基因的分子克隆和表达模式。  |  Ha, HJ., et al. 1992. J Immunol. 148: 1526-31. PMID: 1538135
  3. 作为正常和肿瘤 B 细胞标志物的 IgM 相关蛋白 mb-1。  |  Mason, DY., et al. 1991. J Immunol. 147: 2474-82. PMID: 1747162
  4. 人类 B 细胞上的膜 IgM 缔合作用异二聚体是一种新定义的 B 细胞抗原，它含有 mb-1 基因的蛋白质产物。  |  van Noesel, CJ., et al. 1991. J Immunol. 146: 3881-8. PMID: 2033258
  5. 石蜡包埋组织切片中与白细胞亚群反应的单克隆抗体（MT1, MT2, MB1, MB2, MB3）。  |  Poppema, S., et al. 1987. Am J Pathol. 127: 418-29. PMID: 3296769
  6. CD20/CD79a/PAX5/CD3阴性、肌动蛋白和desmin共表达异常的移植后淋巴瘤--PTLD和PTSMT之间潜在的鉴别诊断陷阱。  |  Suhren, JT., et al. 2022. Ann Hematol. 101: 881-883. PMID: 35179642
  7. CD79A 工作作为预测 OSCC 患者预后的潜在靶细胞：基于 CIBERSORTx 解旋算法的口腔鳞状细胞癌免疫细胞浸润分析。  |  Yao, S., et al. 2023. BMC Oral Health. 23: 411. PMID: 37344840
  8. 鉴定人类 B 细胞抗原受体（BCR）的信号成分--人类 CD79 的独特分子异质性，以及 CD79a 和 CD79b 共同靶向治疗 B 细胞肿瘤的协同增效作用。  |  Seon, BK., et al. 2024. Leuk Res. 136: 107436. PMID: 38232613
  9. CD79a：常规处理组织样本中 B 细胞肿瘤的新型标记物。  |  Mason, DY., et al. 1995. Blood. 86: 1453-9. PMID: 7632952
  10. 人类免疫球蛋白相关 B29 基因（IGB）的分离和染色体图谱绘制。  |  Wood, WJ., et al. 1993. Genomics. 16: 187-92. PMID: 8486355
  11. 使用交叉反应抗肽抗体检测许多动物物种的 T 细胞和 B 细胞。  |  Jones, M., et al. 1993. J Immunol. 150: 5429-35. PMID: 8515069
  12. 脐带 B 淋巴细胞上的抗原受体复合物。  |  Macardle, PJ., et al. 1997. Immunology. 90: 376-82. PMID: 9155644

订购信息

产品名称产品编号规格价格数量收藏夹

CD79A 抗体 (HM47)

sc-20064
200 µg/ml
RMB2377.00

CD79A (HM47): m-IgG Fc BP-HRP 套装

sc-528359
200 µg Ab; 10 µg BP
RMB2662.00

CD79A (HM47): m-IgGκ BP-HRP 套装

sc-520718
200 µg Ab, 40 µg BP
RMB2662.00

CD79A (HM47): m-IgG1 BP-HRP 套装

sc-542890
200 µg Ab; 20 µg BP
RMB2662.00

CD79A 抗体 (HM47) AC

sc-20064 AC
500 µg/ml, 25% agarose
RMB3129.00

CD79A 抗体 (HM47) HRP

sc-20064 HRP
200 µg/ml
RMB2377.00

CD79A 抗体 (HM47) FITC

sc-20064 FITC
200 µg/ml
RMB2482.00

CD79A 抗体 (HM47) PE

sc-20064 PE
200 µg/ml
RMB2580.00

CD79A 抗体 (HM47) Alexa Fluor® 488

sc-20064 AF488
200 µg/ml
RMB2685.00

CD79A 抗体 (HM47) Alexa Fluor® 546

sc-20064 AF546
200 µg/ml
RMB2685.00

CD79A 抗体 (HM47) Alexa Fluor® 594

sc-20064 AF594
200 µg/ml
RMB2685.00

CD79A 抗体 (HM47) Alexa Fluor® 647

sc-20064 AF647
200 µg/ml
RMB2685.00

CD79A 抗体 (HM47) Alexa Fluor® 680

sc-20064 AF680
200 µg/ml
RMB2685.00

CD79A 抗体 (HM47) Alexa Fluor® 790

sc-20064 AF790
200 µg/ml
RMB2685.00

Does this antibody bind the extracellular portion of CD79A? Can it be used for surface staining?

Asked by: SeanC
Thank you for your question. No epitope mapping has been performed for this antibody as of yet, so unfortunately, there is no information about the exact binding site at this point in time.
Answered by: Tech Support Europe
Date published: 2021-11-04

Can CD79A (HM47): sc-20064 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: DefinitelyNotMatt
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD79A (HM47): sc-20064 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from GOODThe antibody effect is great, immunohistochemical staining uniform, positive coloring significantly.
Date published: 2017-09-20
Rated 5 out of 5 by from Found it very usefulIt can be appropriately increased antibody concentration for immunohistochemistry.
Date published: 2017-07-23
Rated 5 out of 5 by from specific stainingHighly specific staining of paraffin-embedded human skin tissue showing cytoplasmic staining of epidermal cells in IF,
Date published: 2017-02-26
Rated 5 out of 5 by from ExcellentCD79A shows very strong staining localized to the human lymph node tissue for Immunoperoxidase applications.
Date published: 2017-02-12
Rated 5 out of 5 by from Good choice for FlowPE conjugated form performs very well in flow cytometry.
Date published: 2017-01-19
Rated 5 out of 5 by from Robust signal in WB in GARobust signal in WB in GA-10 whole cell lysate. -SCBT QC
Date published: 2015-06-29
Rated 5 out of 5 by from Strong staining in IHC in human lymph nodesStrong staining in IHC in human lymph nodes, PCM cells, and bone marrow. -SCBT Publication Review
Date published: 2015-04-04
Rated 5 out of 5 by from Strong band in WB in human transfected 293TStrong band in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-30
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CD79A 抗体 (HM47) is rated 4.9 out of 5 by 12.
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