Date published: 2026-10-24

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CD74 Antibody (PIN.1) - Western Blotting - Image 352052
CD74 抗体 (PIN. 1): sc-47742. 对 Raji (A) 和 Ramos (B) 全细胞裂解液中 CD74 表达的 Western 印迹分析.
CD74 抗体 (PIN. 1): sc-47742. 对 Raji (A) 和 Ramos (B) 全细胞裂解液中 CD74 表达的 Western 印迹分析.

CD74 抗体 (PIN.1): sc-47742

4.3(4)
寫評論提問
说明书
  • CD74抗体(PIN.1)是小鼠单克隆IgG1 κ, 在11篇文献中引用，规格为200 µg/ml
  • 针对DQKPVMDDQRDLISNNE的合成肽，对应于human CD74的氨基酸12-28
  • 推荐用于 mouse, rat 和 human 来源的the epitope in a region of the cytoplasmic tail of CD74 WB, IP, IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 CD74 (LN-2): sc-6262，可查看有标记的 CD74 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和m-IgGκ BP-HRP是CD74 Antibody (PIN.1) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂，这些试剂现与CD74 Antibody (PIN.1) 打包提供（请参阅下面的订购信息）。
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此外 CD74 抗体包括

人类组织相容性白细胞抗原（HLA）II类相关恒定链由至少四种多肽组成。其中一种多肽链表达为膜结合亚基，并被命名为CD74。肽在II类MHC蛋白（MHC II）上的负载似乎受CD74的调节，CD74在迁移到内体室的过程中与MHC II结合，II类结合肽。CD74由T淋巴细胞和B淋巴细胞谱系的细胞表达。事实上，CD74在正常B淋巴细胞中广泛表达，无论其组织相容性白细胞抗原（HLA）表型如何，而MHC II阴性的一组外周T淋巴细胞不表达CD74。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD74 抗体 (PIN.1) 参考文献:

  1. 肾脏管再生中必不可少的MIF-CD74信号轴，有望用于精准医疗和药理增强。  |  Shachar, I. 2017. Am J Physiol Renal Physiol. 313: F1084-F1086. PMID: 28615250
  2. CD74与肠病毒D68的蛋白相互作用，抑制病毒复制。  |  Xiang, Z., et al. 2023. Microbiol Spectr. 11: e0080123. PMID: 37409968
  3. 巨噬细胞迁移抑制因子通过CD74介导皮肤衰老：单细胞和整体RNA测序数据的见解。  |  Wu, S., et al. 2024. Clin Immunol. 263: 110199. PMID: 38565329
  4. 英夫利昔单抗可改变克罗恩病中CD74介导的淋巴异常和脂肪组织改变。  |  Shu, W., et al. 2024. Inflamm Res. 73: 1157-1172. PMID: 38713235
  5. 携带CD74-ROS1融合的骨转移性肺腺癌细胞与巨噬细胞相互作用，促进其扩散。  |  Wang, Z., et al. 2024. Oncogene. 43: 2215-2227. PMID: 38802647
  6. 丙烯酰水解酶通过抑制肾小管CD74-巨噬细胞串联保护肾损伤。  |  Wu, Z., et al. 2024. Int J Biol Sci. 20: 3061-3075. PMID: 38904010
  7. 异基因骨髓移植后，重组CD74+NK细胞可引发慢性移植物抗宿主病。  |  Dou, Y., et al. 2024. J Autoimmun. 147: 103274. PMID: 38936148
  8. APP-CD74轴介导内皮细胞-巨噬细胞之间的沟通，促进肾脏损伤和纤维化。  |  Liu, B., et al. 2024. Front Pharmacol. 15: 1437113. PMID: 39351084
  9. CD74是一种预测免疫检查点阻断反应的潜在生物标志物。  |  Shi, WQ., et al. 2024. Cancer Cell Int. 24: 340. PMID: 39402601

订购信息

产品名称产品编号规格价格数量收藏夹

CD74 抗体 (PIN.1)

sc-47742
200 µg/ml
CNY2422.00

CD74 (PIN.1): m-IgG Fc BP-HRP 套装

sc-536804
200 µg Ab; 10 µg BP
CNY2715.00

CD74 (PIN.1): m-IgGκ BP-HRP 套装

sc-533969
200 µg Ab; 40 µg BP
CNY2715.00

CD74 抗体 (PIN.1) FITC

sc-47742 FITC
200 µg/ml
CNY2527.00

CD74 抗体 (PIN.1) PE

sc-47742 PE
200 µg/ml
CNY2625.00

Can CD74 (PIN.1): sc-47742 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Trav11
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD74 (PIN.1): sc-47742 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by Trav11 from Great antibodyThe CD74 Antibody (PIN.1): sc-47742 works very well for IHC with formalin fixed, paraffin-embedded tissue sections. This antibody has also been cited several times for further verification.
Date published: 2017-02-03
Rated 4 out of 5 by MS from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-06-26
Rated 3 out of 5 by SM from Robust bands seen in WB using BJABRobust bands seen in WB using BJAB, NAMALWA and IB4 whole cell lysates. -SCBT QC
Date published: 2015-04-26
Rated 5 out of 5 by NZ from Produced great immunoperoxidase membraneProduced great immunoperoxidase membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human spleen tissue. -SCBT QC
Date published: 2015-02-15
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CD74抗体 (PIN.1) is rated 4.3 out of 5 by 4.
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