Date published: 2026-10-24

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CD74 Antibody (OX6) - Flow Cytometry - Image 13778
CD74 抗体 (OX6): sc-53062. 大鼠外周血白细胞经 CD74 抗体 (OX6) 染色后的间接 FCM 分析, 然后是 PE 结合物山羊抗小鼠 IgG: sc-3738. 象限标记根据同型对照正常小鼠 IgG1: sc-3877 设置.
CD74 Antibody (OX6) - Flow Cytometry - Image 13778
CD74 抗体 (OX6): sc-53062. 大鼠外周血白细胞经 CD74 抗体 (OX6) 染色后的间接 FCM 分析, 然后是 PE 结合物山羊抗小鼠 IgG: sc-3738. 象限标记根据同型对照正常小鼠 IgG1: sc-3877 设置.
CD74 抗体 (OX6): sc-53062. 大鼠外周血白细胞经 CD74 抗体 (OX6) 染色后的间接 FCM 分析, 然后是 PE 结合物山羊抗小鼠 IgG: sc-3738. 象限标记根据同型对照正常小鼠 IgG1: sc-3877 设置.

CD74 抗体 (OX6): sc-53062

4.8(5)
寫評論提問
说明书
  • CD74抗体(OX6)是小鼠单克隆IgG1 κ, 在6篇文献中引用，规格为200 µg/ml
  • 针对rat来源的RT1b单态/小鼠-I-Ak,s
  • 推荐用于 mouse 和 rat 来源的CD74 WB, IF, IHC(P) 和 FCM检测
  • 还可偶联藻红蛋白 以及 FITC 用于IF, IHC(P) 和 FCM
  • 看 CD74 (LN-2): sc-6262，可查看有标记的 CD74 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP、 1 BP-HRP">m-IgG1 BP-HRP和m-IgGκ BP-HRP是CD74 Antibody (OX6) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与CD74 Antibody (OX6) 打包提供（请参阅下面的订购信息）。
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此外 CD74 抗体包括 CD74L

人类组织相容性白细胞抗原（HLA）II类相关恒定链由至少四种多肽组成。其中一种多肽链表达为膜结合亚基，并被命名为CD74。肽在II类MHC蛋白（MHC II）上的负载似乎受CD74的调节，CD74在迁移到内体室的过程中与MHC II结合，II类结合肽。CD74由T淋巴细胞和B淋巴细胞谱系的细胞表达。事实上，CD74在正常B淋巴细胞中广泛表达，无论其组织相容性白细胞抗原（HLA）表型如何，而MHC II阴性的一组外周T淋巴细胞不表达CD74。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD74 抗体 (OX6) 参考文献:

  1. CD74由多发性骨髓瘤表达，是很有前景的治疗靶点。  |  Burton, JD., et al. 2004. Clin Cancer Res. 10: 6606-11. PMID: 15475450
  2. 无辜伴侣的隐秘第二人生：CD74和B细胞/慢性淋巴细胞白血病细胞存活的故事。  |  Shachar, I. and Haran, M. 2011. Leuk Lymphoma. 52: 1446-54. PMID: 21417823
  3. 子痫前期胎盘巨噬细胞-滋养细胞相互作用的 CD74 下调  |  Przybyl, L., et al. 2016. Circ Res. 119: 55-68. PMID: 27199465
  4. CD74 信号将炎症与肠上皮细胞再生联系起来，并促进粘膜愈合。  |  Farr, L., et al. 2020. Cell Mol Gastroenterol Hepatol. 10: 101-112. PMID: 32004754
  5. 抑制疟原虫MIF-CD74信号可预防严重疟疾。  |  Baeza Garcia, A., et al. 2021. FASEB J. 35: e21997. PMID: 34719814
  6. 凋亡巨噬细胞中的 CD74 与人类动脉粥样硬化病变中的炎症、斑块进展和临床表现有关。  |  Li, W., et al. 2022. Metabolites. 12: PMID: 35050177
  7. 洞察CD74在泛癌症中的预后价值和免疫学作用。  |  Liu, Z., et al. 2024. Discov Oncol. 15: 222. PMID: 38861249
  8. 单细胞转录组分析揭示了APP-CD74轴促进免疫抑制和睾丸肿瘤进展。  |  Chen, G., et al. 2024. J Pathol. 264: 250-269. PMID: 39161125
  9. 姜黄素/pEGCG包裹的纳米粒子通过调节CD74减轻氧化应激和炎症，从而促进脊髓损伤的恢复。  |  Chen, T., et al. 2024. J Nanobiotechnology. 22: 653. PMID: 39443923
  10. CD74通过诱导耐受性树突状细胞和调节性B细胞的扩张，在小鼠的三阴性乳腺癌中促进形成免疫抑制性肿瘤微环境。  |  Pellegrino, B., et al. 2024. PLoS Biol. 22: e3002905. PMID: 39576827

订购信息

产品名称产品编号规格价格数量收藏夹

CD74 抗体 (OX6)

sc-53062
200 µg/ml
CNY2422.00

CD74 (OX6): m-IgG Fc BP-HRP 套装

sc-536883
200 µg Ab; 10 µg BP
CNY2715.00

CD74 (OX6): m-IgGκ BP-HRP 套装

sc-534053
200 µg Ab; 40 µg BP
CNY2715.00

CD74 (OX6): m-IgG1 BP-HRP 套装

sc-544875
200 µg Ab; 20 µg BP
CNY2715.00

CD74 抗体 (OX6) FITC

sc-53062 FITC
200 µg/ml
CNY2527.00

CD74 抗体 (OX6) PE

sc-53062 PE
200 µg/ml
CNY2625.00

I am working on rat dorsal root ganglion (DRG) samples and plan to perform Western blot and immunofluorescence on frozen sections. Could you please advise whether OX-6 or LN-2 is more suitable or has been validated for rat DRG in these applications?

Asked by: Kenzie
Thank you for your question. It would be helpful if you could email us directly at [email protected]. So we can have a more interactive discussion about this and other related issues.
Answered by: Zhanglong
Date published: 2026-01-30

Can CD74 (OX6): sc-53062 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Professor Griffin
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD74 (OX6): sc-53062 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by TinTin from Great for Flow CytometryExcellent choice for CD74, gives nice Flow cytometry data!
Date published: 2017-02-03
Rated 5 out of 5 by HF from Publishable IHC data in rat spinal cord tissuePublishable IHC data in rat spinal cord tissue. -SCBT Publication Review
Date published: 2015-06-01
Rated 5 out of 5 by SS from Publishable data obtained by WB using mousePublishable data obtained by WB using mouse IKDC and NK from spleen. -SCBT Publication Review
Date published: 2015-05-19
Rated 5 out of 5 by MS from It has been reported that product scIt has been reported that product sc-53062 is suitable for use in IF using rat brain and dentate gyrus tissue. -SCBT Publication Review
Date published: 2015-01-27
Rated 4 out of 5 by TO from Produced robust indirect FCM data for ratProduced robust indirect FCM data for rat peripheral blood leukocytes stained CD74 . -SCBT QC
Date published: 2014-11-15
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CD74 抗体 (OX6) is rated 4.8 out of 5 by 5.
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