Date published: 2026-10-24

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CD74 Antibody (M-B741) - Western Blotting - Image 16359
CD74 抗体 (M-B741): sc-65272. NAMALWA (A), BJAB (B) 和 IB4 (C) 全细胞裂解液中 CD74 表达的 Western 印迹分析.
CD74 抗体 (M-B741): sc-65272. NAMALWA (A), BJAB (B) 和 IB4 (C) 全细胞裂解液中 CD74 表达的 Western 印迹分析.

CD74 抗体 (M-B741): sc-65272

4.6(7)
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说明书
  • CD74抗体(M-B741)是小鼠单克隆IgG2a κ, 在1篇文献中引用，规格为200 µg/ml
  • 针对human来源的RPMI 1788细胞系
  • 推荐用于 mouse, rat 和 human 来源的CD74 WB, IP, IF, IHC(P) 和 FCM检测
  • 看 CD74 (LN-2): sc-6262，可查看有标记的 CD74 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 2a BP-HRP">m-IgG2a BP-HRP是CD74 Antibody (M-B741) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与CD74 Antibody (M-B741) 打包提供（请参阅下面的订购信息）。
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此外 CD74 抗体包括 CD74L

人类组织相容性白细胞抗原（HLA）II类相关恒定链由至少四种多肽组成。其中一种多肽链表达为膜结合亚基，并被命名为CD74。肽在II类MHC蛋白（MHC II）上的负载似乎受CD74的调节，CD74在迁移到内体室的过程中与MHC II结合，II类结合肽。CD74由T淋巴细胞和B淋巴细胞谱系的细胞表达。事实上，CD74在正常B淋巴细胞中广泛表达，无论其组织相容性白细胞抗原（HLA）表型如何，而MHC II阴性的一组外周T淋巴细胞不表达CD74。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD74 抗体 (M-B741) 参考文献:

  1. MIF/CD74 轴是结肠癌新疗法的靶点。  |  Bozzi, F., et al. 2017. J Exp Clin Cancer Res. 36: 16. PMID: 28114961
  2. CD74 缺陷可减轻小鼠的系统性红斑狼疮样自身免疫和病理结果。  |  Zhou, Y., et al. 2017. J Immunol. 198: 2568-2577. PMID: 28219888
  3. 肾细胞癌中的HLA-DR和CD74表达以及免疫微环境。  |  Miura, Y., et al. 2021. Anticancer Res. 41: 2841-2848. PMID: 34083274
  4. 脑转移癌症患者CTC上的CD74和CD44表达。  |  Loreth, D., et al. 2021. Int J Mol Sci. 22: PMID: 34209696
  5. 鉴定不变链 CD74 作为组织金属蛋白酶抑制剂-1（TIMP-1）的功能受体。  |  Schoeps, B., et al. 2021. J Biol Chem. 297: 101072. PMID: 34391782
  6. 可溶性CD74和巨噬细胞迁移抑制因子之间的相互作用可促进肿瘤生长并影响黑色素瘤患者的生存。  |  Fukuda, Y., et al. 2022. Cell Death Dis. 13: 117. PMID: 35121729
  7. 肿瘤坏死因子α依赖性肺部炎症通过上调 MIF-CD74 促进肺泡 II 型细胞肺腺癌的进展。  |  Cao, L., et al. 2023. Lab Invest. 103: 100034. PMID: 36925198
  8. 组织金属蛋白酶抑制剂-1 与 CD74 相互作用，促进 AKT 信号、单核细胞招募反应和血管平滑肌细胞增殖。  |  Ebert, S., et al. 2023. Cells. 12: PMID: 37508563
  9. 外周血记忆B细胞分泌的迁移抑制因子与CD74-CD44受体复合物结合，可影响阿尔茨海默病中的巨噬细胞行为。  |  Liu, B., et al. 2024. Am J Alzheimers Dis Other Demen. 39: 15333175241238577. PMID: 38491918
  10. 间充质干细胞来源的外泌体通过CD74调节小鼠巨噬细胞极化来预防腹主动脉瘤的形成。  |  Xu, J., et al. 2024. Stem Cell Res Ther. 15: 242. PMID: 39098899

订购信息

产品名称产品编号规格价格数量收藏夹

CD74 抗体 (M-B741)

sc-65272
200 µg/ml
CNY2422.00

CD74 (M-B741): m-IgG Fc BP-HRP 套装

sc-539169
200 µg Ab; 10 µg BP
CNY2715.00

CD74 (M-B741): m-IgG2a BP-HRP 套装

sc-546677
200 µg Ab; 10 µg BP
CNY2715.00

I am using CD74 (M-B741): sc-65272 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: TinTin
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by LM from Produced superb indirect FCM data for BJABProduced superb indirect FCM data for BJAB cells stained with CD74 . -SCBT QC
Date published: 2015-06-01
Rated 4 out of 5 by CJ from Nice band seen in WB using NAMALWA wholeNice band seen in WB using NAMALWA whole cell lysate. -SCBT QC
Date published: 2015-05-29
Rated 4 out of 5 by NZ from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-05-25
Rated 5 out of 5 by MC from Produced excellent immunoperoxidase membraneProduced excellent immunoperoxidase membrane and cytoplasmic staining in formalin fixed, paraffin-embedded human spleen tissue. -SCBT QC
Date published: 2015-05-07
Rated 4 out of 5 by NZ from Strong bands seen in WB using NAMALWAStrong bands seen in WB using NAMALWA, BJAB and IB4 whole cell lysates. -SCBT QC
Date published: 2015-04-30
Rated 5 out of 5 by QZ from Published WB data with human Mel JuSolPublished WB data with human Mel JuSol - SCBT Publication Review
Date published: 2015-04-20
Rated 5 out of 5 by TO from Produced great indirectProduced great indirect, intracellular FCM data for fixed and permeabilized human peripheral blood leukocytes stained with CD74 . -SCBT QC
Date published: 2013-09-23
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CD74 抗体 (M-B741) is rated 4.6 out of 5 by 7.
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