Date published: 2026-10-24

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CD74 Antibody (D-6) - Western Blotting - Image 352060
CD74 抗体 (D-6): sc-137217. 对 IB4 (A) 和 Ramos (B) 全细胞裂解液以及人肾上腺组织提取物 (C) 中 CD74 表达的 Western 印迹分析.
CD74 抗体 (D-6): sc-137217. 对 IB4 (A) 和 Ramos (B) 全细胞裂解液以及人肾上腺组织提取物 (C) 中 CD74 表达的 Western 印迹分析.

CD74 抗体 (D-6): sc-137217

4.3(4)
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说明书
  • CD74抗体(D-6)是小鼠单克隆IgG1 κ, 在1篇文献中引用，规格为200 µg/ml
  • 针对氨基酸17-296，在CD74的human起源的C-terminus处进行映射
  • 推荐用于 mouse, rat 和 human 来源的CD74 WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 CD74 (LN-2): sc-6262，可查看有标记的 CD74 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是CD74 Antibody (D-6) for WB and IHC(P) applications. 的首选辅助检测试剂，这些试剂现与CD74 Antibody (D-6) 打包提供（请参阅下面的订购信息）。
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此外 CD74 抗体包括 CD74L

人类组织相容性白细胞抗原（HLA）II类相关恒定链由至少四种多肽组成。其中一种多肽链以膜结合亚基的形式表达，并被命名为CD74。肽在II类MHC蛋白（MHC II）上的负载似乎受CD74的调节，CD74在迁移到内体室的过程中与MHC II结合，II类结合肽。CD74由T淋巴细胞和B淋巴细胞谱系的细胞表达。事实上，CD74在正常B淋巴细胞中广泛表达，无论其组织相容性白细胞抗原（HLA）表型如何，而MHC II阴性的一组外周T淋巴细胞不表达CD74。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD74 抗体 (D-6) 参考文献:

  1. CD74 是结肠上皮细胞的一种存活受体。  |  Maharshak, N., et al. 2010. World J Gastroenterol. 16: 3258-66. PMID: 20614481
  2. 巨噬细胞迁移抑制因子和CD74通过MAPK和Rho GTPase调节巨噬细胞的趋化反应。  |  Fan, H., et al. 2011. J Immunol. 186: 4915-24. PMID: 21411731
  3. CD74和巨噬细胞迁移抑制因子作为胃癌的治疗靶点。  |  Zheng, YX., et al. 2012. World J Gastroenterol. 18: 2253-61. PMID: 22611320
  4. CD74：三阴性乳腺癌的潜在新靶点。  |  Tian, B., et al. 2012. Tumour Biol. 33: 2273-7. PMID: 22935920
  5. 病毒编码的异位CD74可提高痘病毒疫苗的效力。  |  Walline, CC., et al. 2014. Immunology. 141: 531-9. PMID: 24205828
  6. CD74/DQA1二聚体易导致人源化小鼠关节炎的发生。  |  David, L., et al. 2016. Immunology. 147: 204-11. PMID: 26524976
  7. 非放射线性轴突性脊柱关节炎的CD74自身抗体的敏感性和特异性。  |  Riechers, E., et al. 2019. Arthritis Rheumatol. 71: 729-735. PMID: 30418704
  8. CD74，早产儿支气管肺发育不良的新预测因子。  |  Gao, J., et al. 2020. Medicine (Baltimore). 99: e23477. PMID: 33235138
  9. MIF的N端调节参与CD74激活的残基的动态分布。  |  Parkins, A., et al. 2021. Biophys J. 120: 3893-3900. PMID: 34437846
  10. 黑色素瘤中MIF、DDT和CD74的预后和治疗见解。  |  Valdez, CN., et al. 2024. Oncotarget. 15: 507-520. PMID: 39028303

订购信息

产品名称产品编号规格价格数量收藏夹

CD74 抗体 (D-6)

sc-137217
200 µg/ml
CNY2422.00

CD74 (D-6): m-IgG Fc BP-HRP 套装

sc-539962
200 µg Ab; 10 µg BP
CNY2715.00

CD74 (D-6): m-IgG1 BP-HRP 套装

sc-541817
200 µg Ab; 20 µg BP
CNY2715.00

Can CD74 (D-6): sc-137217 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: Dr Ninau Qelp
Thank you for your question. Yes, CD74 (D-6): sc-137217 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-28
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Rated 5 out of 5 by nanpengwan from great performanceThe expression of CD74 in IB4 was analyzed by Western blot analysis with Ramos and Western (B) whole cell lysates and human adrenal tissue extracts (C).
Date published: 2017-01-08
Rated 4 out of 5 by FL from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-05-27
Rated 3 out of 5 by CJ from Robust band seen in WB using BJAB whole cellRobust band seen in WB using BJAB whole cell lysate. -SCBT QC
Date published: 2015-03-06
Rated 5 out of 5 by SH from Exceptional immunofluorescence cytoplasmicExceptional immunofluorescence cytoplasmic staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2015-01-10
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CD74 抗体 (D-6) is rated 4.3 out of 5 by 4.
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