Date published: 2025-9-6

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CD46 抗体 (E4.3): sc-7634

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说明书
  • CD46抗体(E4.3)是小鼠单克隆IgG2a κ, 在9篇文献中引用,规格为200 µg/ml
  • 针对human PBL和EBV转化后的LCL
  • CD46 抗体 (E4.3) 推荐用于WB, IP, IF 和 FCM,检测human 来源的 CD46
  • 抗CD46抗体(E4.3)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CD46 (E4.3): sc-7634免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRPm-IgGκ BP-HRP是CD46 Antibody (E4.3) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CD46 Antibody (E4.3) 打包提供(请参阅下面的订购信息)。

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関連項目

CD46抗体(E4.3)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和流式细胞术(FCM)检测人类CD46。抗CD46抗体(E4.3)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。CD46,也称为膜辅助因子蛋白(MCP),是一种重要的跨膜糖蛋白,在调节补体系统方面发挥着重要作用,而补体系统对于免疫反应和炎症至关重要。CD46以非二硫键连接的双聚体形式存在,主要位于免疫细胞表面,如胸腺细胞、T细胞、B细胞、单核细胞和粒细胞,以及内皮细胞和上皮细胞。这些细胞上的CD46对于防止补体介导的自身组织损伤至关重要,因为CD46是丝氨酸蛋白酶因子I降解C3b和C4b的辅助因子。这种调节功能主要归因于CD46结构中的补体控制蛋白重复序列(CCPs),尤其是对活性至关重要的CCP1-4。此外,CD46还是麻疹病毒和人类疱疹病毒等病原体的高亲和力受体,这凸显了CD46在免疫调节和病毒致病性中的重要性。小鼠细胞表达CRRY,它是人类衰亡加速因子(DAF或CD55)和膜辅助因子蛋白(MCP或CD46)的功能同源物,进一步强调了CD46的功能在物种间进化上的保守性。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD46 抗体 (E4.3) 参考文献:

  1. 多发性硬化症中CD46的可塑性和炎症倾向。  |  Ni Choileain, S. and Astier, AL. 2011. Arch Immunol Ther Exp (Warsz). 59: 49-59. PMID: 21267793
  2. 先天性和适应性免疫中的CD46:最新进展。  |  Cardone, J., et al. 2011. Clin Exp Immunol. 164: 301-11. PMID: 21488871
  3. CD46基因变异与HIV-1感染易感性。  |  Serrano-Rísquez, C., et al. 2021. Cells. 10: PMID: 34831317
  4. CD46靶向212Pbα粒子放射免疫疗法治疗前列腺癌。  |  Li, J., et al. 2023. J Exp Clin Cancer Res. 42: 61. PMID: 36906664
  5. CD46靶向225Acα粒子放射免疫疗法治疗前列腺癌。  |  Bidkar, AP., et al. 2023. Clin Cancer Res. 29: 1916-1928. PMID: 36917693
  6. CD46依赖性免疫失调的免疫学和遗传学因素。  |  Meyer, BJ., et al. 2023. J Clin Immunol. 43: 1840-1856. PMID: 37477760
  7. CD46在雄性和雌性青春期小鼠中枢神经系统中的表达。  |  Esposito, P., et al. 2023. J Neuroimmunol. 385: 578234. PMID: 37944208
  8. CD46-ADC降低多发性骨髓瘤患者异种移植的植入率。  |  VanWyngarden, MJ., et al. 2023. Cancers (Basel). 15: PMID: 38001595
  9. CD46靶向治疗诊断学在PET和225Ac放射性药物治疗多发性骨髓瘤中的应用。  |  Wadhwa, A., et al. 2024. Clin Cancer Res. 30: 1009-1021. PMID: 38109209
  10. 可溶性CD46作为肝脂肪化的诊断标志物。  |  Bitterer, F., et al. 2024. EBioMedicine. 104: 105184. PMID: 38838471

订购信息

产品名称产品编号规格价格数量收藏夹

CD46 抗体 (E4.3)

sc-7634
200 µg/ml
RMB2377.00

CD46 (E4.3): m-IgG Fc BP-HRP 套装

sc-528185
200 µg Ab; 10 µg BP
RMB2662.00

CD46 (E4.3): m-IgGκ BP-HRP 套装

sc-520507
200 µg Ab, 40 µg BP
RMB2662.00

CD46 (E4.3): m-IgG2a BP-HRP 套装

sc-547040
200 µg Ab; 10 µg BP
RMB2662.00

CD46 抗体 (E4.3) AC

sc-7634 AC
500 µg/ml, 25% agarose
RMB3129.00

CD46 抗体 (E4.3) HRP

sc-7634 HRP
200 µg/ml
RMB2377.00

CD46 抗体 (E4.3) FITC

sc-7634 FITC
200 µg/ml
RMB2482.00

CD46 抗体 (E4.3) PE

sc-7634 PE
200 µg/ml
RMB2580.00

CD46 抗体 (E4.3) Alexa Fluor® 488

sc-7634 AF488
200 µg/ml
RMB2685.00

CD46 抗体 (E4.3) Alexa Fluor® 546

sc-7634 AF546
200 µg/ml
RMB2685.00

CD46 抗体 (E4.3) Alexa Fluor® 594

sc-7634 AF594
200 µg/ml
RMB2685.00

CD46 抗体 (E4.3) Alexa Fluor® 647

sc-7634 AF647
200 µg/ml
RMB2685.00

CD46 抗体 (E4.3) Alexa Fluor® 680

sc-7634 AF680
200 µg/ml
RMB2685.00

CD46 抗体 (E4.3) Alexa Fluor® 790

sc-7634 AF790
200 µg/ml
RMB2685.00

Can we get the immunogen?

Asked by: maomaomao
Thank you for your question. This antibody was raised against human PBL and EBV transformed LCL. The exact epitope has not been mapped, so we are unable to provide further information.
Answered by: Tech Service
Date published: 2019-10-21

Can CD46 (E4.3): sc-7634 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: Trav11
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent, CD46 (E4.3): sc-7634 is available in a variety of direct conjugations, such as HRP, PE, FITC and AlexaFluors.
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Published good quality flow cytometry dataPublished good quality flow cytometry data in Various canine cell lines -SCBT Publication Review
Date published: 2015-07-11
Rated 5 out of 5 by from Good WB publishable data gathered with humanGood WB publishable data gathered with human epithelial cells. -SCBT Publication Review
Date published: 2015-07-09
Rated 4 out of 5 by from Produced nice FCM data for CCRFProduced nice FCM data for CCRF-CEM cells. -SCBT QC
Date published: 2015-07-07
Rated 4 out of 5 by from This antibody works well and can be usedThis antibody works well and can be used for IP with human PBMC, NIH/3T3, RK 13 and HSB-2 cells. -SCBT Publication Review
Date published: 2015-04-05
Rated 4 out of 5 by from Exceptional immunofluorescence membrane stainingExceptional immunofluorescence membrane staining in methanol-fixed Ramos cells. -SCBT QC
Date published: 2015-03-10
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CD46 抗体 (E4.3) is rated 4.4 out of 5 by 5.
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