Date published: 2025-9-6

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CD137L 抗体 (G-10): sc-398933

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说明书
  • CD137L 抗体 G-10 是小鼠单克隆 IgM κ,CD137L抗体, 在1篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于mouse物种的CD137L的N-terminus附近的氨基酸41-67之间
  • 推荐用于 mouse, rat 和 human 来源的CD137L WB, IP, IF 和 ELISA检测
  • 关于如何获取CD137L (G-10): sc-398933免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成CD137L 抗体 (G-10)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

CD137L抗体(G-10)是一种IgM κ小鼠单克隆CD137L抗体(也称为CD137L抗体),可通过WB, IP, IF和ELISA检测小鼠、大鼠和人源的CD137L蛋白。CD137L抗体(G-10)可作为非偶联的抗CD137L抗体使用。CD137,在小鼠中也称为ILA和4-1BB,属于肿瘤坏死因子受体家族,并向T淋巴细胞传递共刺激信号。CD137在活化的T细胞上表达,并与B细胞、巨噬细胞和树突状细胞上发现的一种可诱导配体结合。CD137与其配体之间的相互作用参与抗原呈递和细胞毒性T细胞的生成。CD137配体的交联可诱导静止淋巴细胞的凋亡。相反,CD137通过诱导细胞因子释放来调节外周单核细胞的存活,这一过程由M-CSF介导,并在较小程度上由粒细胞-巨噬细胞集落刺激因子和IL-3介导。类风湿性关节炎患者血清中发现的可溶性CD137可能为免疫反应提供负调控机制。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CD137L 抗体 (G-10) 参考文献:

  1. 发现 CD137 是一种有效的单核细胞存活因子  |  Langstein, J. and Schwarz, H. 1999. J Leukoc Biol. 65: 829-33. PMID: 10380906
  2. CD137 诱导的细胞凋亡与 CD95 无关。  |  Michel, J., et al. 1999. Immunology. 98: 42-6. PMID: 10469232
  3. 原代人类单核细胞表达的 CD137(ILA/4-1BB)可诱导单核细胞活化和 B 淋巴细胞凋亡。  |  Kienzle, G. and von Kempis, J. 2000. Int Immunol. 12: 73-82. PMID: 10607752
  4. 4-1BB 配体对抗原特异性 CD4 T 细胞的协同刺激。  |  Gramaglia, I., et al. 2000. Eur J Immunol. 30: 392-402. PMID: 10671194
  5. 可溶性 CD137 的表达与活化诱导的淋巴细胞死亡相关。  |  Michel, J. and Schwarz, H. 2000. Cytokine. 12: 742-6. PMID: 10843756
  6. 4-1BB:仍在黑暗之中。  |  Kwon, B., et al. 2000. Mol Cells. 10: 119-26. PMID: 10850651
  7. CD137 和 LPS 对单核细胞活化, 存活和增殖影响的比较分析  |  Langstein, J., et al. 2000. Biochem Biophys Res Commun. 273: 117-22. PMID: 10873573

订购信息

产品名称产品编号规格价格数量收藏夹

CD137L 抗体 (G-10)

sc-398933
200 µg/ml
RMB2377.00

CD137L (G-10) 中和勝肽

sc-398933 P
100 µg/0.5 ml
RMB511.00

Why this antibody detects a 60 KDa protein? I have reviewed other antibodies and they report a molecular weight of approximately 20 KDa. How is possible this difference?

Asked by: Maiv
Thank you very much for your question. CD137L is a heavily glycosylated transmembrane protein consisting of 309 amino acids. The molecular weight expected to be observed in a standard Western Blot experiment is roughly around 60 kDa as shown in the WB images on the product sheet and website. For sc-65279 we show a much smaller WB band because this is a truncated recombinant protein fragment with a much smaller size.
Answered by: Technical Support Europe
Date published: 2025-06-04

What application is the blocking peptide sc-398933 P appropriate for?

Asked by: Germaine
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-25
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Rated 5 out of 5 by from Satisfactory Western Blot data of CD137LSatisfactory Western Blot data of CD137L expression in SP2/0, TK-1, P388D1 and RBL-1 whole cell lysates. -SCBT QC
Date published: 2015-05-07
Rated 5 out of 5 by from Satisfactory Western Blot data of CD137LSatisfactory Western Blot data of CD137L expression in CTLL-2, COLO 320DM, Raji, CCRF-CEM, HEK293 and HCT-116 whole cell lysates. -SCBT QC
Date published: 2013-05-14
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CD137L 抗体 (G-10) is rated 5.0 out of 5 by 2.
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