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Uteroglobin/SCGB1A1/CC10 Antibody (E-11) - Western Blotting - Image 394230
CC10 抗体 (E-11) Alexa Fluor® 647: sc-365992 AF647. A549 (A), NCI-H292 (B), WI-38 (C), AMJ2-C8 (D), SHP-77 (E) 和 H69AR (F) 全细胞裂解液中 CC10 表达的直接荧光印迹分析. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 用 Cruz Marker™ MW Tag-Alexa Fluor® 488 检测 Cruz Marker™ 分子量标准: sc-516790.
CC10 抗体 (E-11) Alexa Fluor® 647: sc-365992 AF647. A549 (A), NCI-H292 (B), WI-38 (C), AMJ2-C8 (D), SHP-77 (E) 和 H69AR (F) 全细胞裂解液中 CC10 表达的直接荧光印迹分析. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 用 Cruz Marker™ MW Tag-Alexa Fluor® 488 检测 Cruz Marker™ 分子量标准: sc-516790.

Uteroglobin/SCGB1A1/CC10 抗体 (E-11): sc-365992

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说明书
  • Uteroglobin/SCGB1A1/CC10 抗体 E-11 是小鼠单克隆 IgG1 κ，Uteroglobin/SCGB1A1/CC10抗体, 在84篇文献中引用，规格为200 µg/ml
  • 免疫human物种的CC10的氨基酸17-91
  • Uteroglobin/SCGB1A1/CC10 抗体 (E-11) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 CC10
  • 抗Uteroglobin/SCGB1A1/CC10抗体（E-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Uteroglobin/SCGB1A1/CC10 (E-11): sc-365992的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Uteroglobin/SCGB1A1/CC10 抗体 (E-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Uteroglobin/SCGB1A1/CC10 抗体 (E-11) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

CC10抗体（E-11）是一种IgG1 κ小鼠单克隆CC10抗体（也称为SCGB1A1抗体或分泌球蛋白家族1A成员1抗体），可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人源的CC10蛋白。CC10抗体（E-11）既有非偶联的抗CC10抗体形式，也有多种偶联形式的抗CC10抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Clara细胞10（CC10）蛋白是兔子宫球蛋白的同源物，是一种磷脂酶A2抑制剂。CC10受AP-1、八聚体和肝细胞核因子-3（HNF-3）家族转录因子的调控。CC10的表达随卵巢月经周期而变化，人类子宫内膜中的表达可能受孕酮刺激，这表明CC10可能调节人类子宫中的类花生酸水平。CC10表达于肺部的非纤毛气道上皮细胞和泌尿生殖道分泌物中。CC10参与调节气道炎症，可能在哮喘中发挥作用。非小细胞肺癌细胞系A549中CC10的过度表达显示，MMP-2和MMP-9基质金属蛋白酶几乎完全缺失，侵袭性降低，这表明CC10的缺失可能促进癌变。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) 参考文献:

  1. 人类尿液蛋白 1：与克拉拉细胞蛋白相同的证据以及在呼吸道和尿道分泌物中的出现。  |  Bernard, A., et al. 1992. Clin Chim Acta. 207: 239-49. PMID: 1395029
  2. 妊娠和机械通气对通气和非通气新生儿血清透明细胞分泌蛋白（CC10）浓度的影响。  |  Loughran-Fowlds, A., et al. 2006. Pediatr Res. 60: 103-8. PMID: 16690962
  3. 在化学预防试验参与者中，抗炎蛋白CC10与吸烟状态之间的关联。  |  Chen, J., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 577-83. PMID: 17372255
  4. 在肺癌高危人群中，抗炎蛋白CC10水平升高与支气管发育不良和痰细胞学评估的改善有关。  |  Chen, J., et al. 2008. Clin Cancer Res. 14: 1590-7. PMID: 18316584
  5. 接触苯乙烯或其代谢物氧化苯乙烯或 4-乙烯基苯酚后，CD-1 小鼠 Clara 细胞中 CC10 mRNA 和蛋白质的表达。  |  Harvilchuck, JA., et al. 2008. Toxicol Lett. 183: 28-35. PMID: 18926891
  6. 大鼠克拉拉细胞 10 kDa 蛋白的组织特异性表达, 激素调节和 5'-flanking 基因区：与兔子宫血红蛋白的比较。  |  Hagen, G., et al. 1990. Nucleic Acids Res. 18: 2939-46. PMID: 2349092
  7. 克拉拉细胞 10 kDa 蛋白（CC10）：与子宫血红蛋白的结构和功能比较。  |  Singh, G., et al. 1990. Biochim Biophys Acta. 1039: 348-55. PMID: 2378892
  8. 人体子宫内膜中 Clara 细胞 10-kD 基因的表达及其与卵巢月经周期的关系。  |  Peri, A., et al. 1994. DNA Cell Biol. 13: 495-503. PMID: 7517678
  9. 气道上皮细胞中人类 CC10 基因的表达和亚染色体位点表明与气道疾病有关。  |  Hay, JG., et al. 1995. Am J Physiol. 268: L565-75. PMID: 7733299
  10. 肺特异性 CC10 基因受 AP-1, 八聚体和肝细胞核因子 3 家族转录因子的调控。  |  Sawaya, PL., et al. 1993. Mol Cell Biol. 13: 3860-71. PMID: 8321193
  11. 吸烟者的血清和BAL Clara细胞10 kDa蛋白（CC10）水平以及CC10阳性细支气管细胞减少。  |  Shijubo, N., et al. 1997. Eur Respir J. 10: 1108-14. PMID: 9163654
  12. CC10的过表达可改变肺癌细胞的癌变潜能。  |  Szabo, E., et al. 1998. Cell Growth Differ. 9: 475-85. PMID: 9663466

订购信息

产品名称产品编号规格价格数量收藏夹

Uteroglobin/SCGB1A1/CC10 抗体 (E-11)

sc-365992
200 µg/ml
RMB2377.00

Uteroglobin/SCGB1A1/CC10 (E-11): m-IgG Fc BP-HRP 套装

sc-529534
200 µg Ab; 10 µg BP
RMB2662.00

Uteroglobin/SCGB1A1/CC10 (E-11): m-IgGκ BP-HRP 套装

sc-522453
200 µg Ab, 40 µg BP
RMB2662.00

Uteroglobin/SCGB1A1/CC10 (E-11): m-IgG1 BP-HRP 套装

sc-543563
200 µg Ab; 20 µg BP
RMB2662.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) AC

sc-365992 AC
500 µg/ml, 25% agarose
RMB3129.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) HRP

sc-365992 HRP
200 µg/ml
RMB2377.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) FITC

sc-365992 FITC
200 µg/ml
RMB2482.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) PE

sc-365992 PE
200 µg/ml
RMB2580.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 488

sc-365992 AF488
200 µg/ml
RMB2685.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 546

sc-365992 AF546
200 µg/ml
RMB2685.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 594

sc-365992 AF594
200 µg/ml
RMB2685.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 647

sc-365992 AF647
200 µg/ml
RMB2685.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 680

sc-365992 AF680
200 µg/ml
RMB2685.00

Uteroglobin/SCGB1A1/CC10 抗体 (E-11) Alexa Fluor® 790

sc-365992 AF790
200 µg/ml
RMB2685.00

Can CC10 (E-11) monoclonal antibody be used on FFPE-hamster lung tissue for immunofluorescent staining?

Asked by: Haedol
Thank you for your question. It would be helpful if you could call us, allowing for a more interactive discussion of this and other related questions.
Answered by: Technical Support
Date published: 2021-07-22

What should be the Isotype control for flow Cytometry experiments with CC10 Antibody (E-11) Alexa Fluor® 647?

Asked by: ktgmgh
Thank you for your question. The isotope control for this product is normal mouse IgG1 Alexa Fluor® 647: sc-24636. https://www.scbt.com/p/normal-mouse-igg1-alexa-fluor-647
Answered by: Technical Service 3
Date published: 2020-11-16

For mouse lung flow Cytometry, permeabilization is required before staining?

Asked by: mghktg
Thank you for your question. CC10 is a secreted protein, and permeabilization may be necessary. You can find our recommended Flow cytometry protocol here: https://www.scbt.com/resources/protocols/flow-cytometry
Answered by: Tech Service
Date published: 2020-11-09

Have you checked whether this antibody (anti-CC10 antibody (E-11): sc-365992) works well with mouse lung tissue IF or IHC?

Asked by: Hiroki KIMURA
Thank you for your question. This antibody has been tested by IHC in human samples, but we do not have published data in mouse samples. We do warranty it for IF on mouse samples as it is a mouse reactive antibody! Please contact our Technical Service Department by phone, e-mail or live chat if you have any further questions.
Answered by: Tech Service
Date published: 2017-04-27

Can CC10 (E-11): sc-365992 be frozen?

Asked by: jenniferc
No. The antibody solution contains gelatin. When the gelatin is frozen the antibody precipitates out of solution. However, if an antibody’s datasheet says that the antibody should be stored frozen, then the antibody can be frozen, as these antibodies do not contain gelatin.
Answered by: Technical Support 15
Date published: 2017-01-24
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Rated 5 out of 5 by from This antibody works very well for IFCThis antibody works very well for immunofluorescence (mouse lung tissue)
Date published: 2023-06-20
Rated 4 out of 5 by from CC10Cells were fixed in 4% PFA at room temperature (RT) for 15 min, and permeabilized in 0.2% Triton X-100 at RT for 20 min. CC10 antibody was used 1/100 diluted in FACS buffer, supplemented with 60µg/ml human IgG) for overnight at 8°C. The cells were washed and analyzed by flow cytometry.
Date published: 2023-01-16
Rated 5 out of 5 by from Great signal for IHC-PCC10 was detected in immunofluorescence on mice bronchiole paraffin sections. Dilution 1: 200. Sodium citrate antigen retrieval was performed.
Date published: 2020-10-19
Rated 5 out of 5 by from Good for immunofluorescenceThe CC10 antibody works well for immunofluorescence
Date published: 2019-04-09
Rated 5 out of 5 by from Great Ab for IHCparaffin embedded lung section/Sodium citrate antigen retrieval
Date published: 2018-01-10
Rated 5 out of 5 by from strong signal with clear backgrountI asked the sample, which works so well in the immunostaining for cytospins.
Date published: 2017-12-08
Rated 5 out of 5 by from 人肺一年前买的，很好使，染得很特异，没有什么背景，可能 CC10本身表达量也比较高，容易染，也买过其他的抗体
Date published: 2017-09-18
Rated 5 out of 5 by from Excellent work of CC10 for IFCC10 was detected on rat bronchiole paraffin sections via the techonology of IF. Dilution 1: 200.
Date published: 2017-08-15
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Uteroglobin/SCGB1A1/CC10 抗体 (E-11) is rated 4.9 out of 5 by 12.
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