Date published: 2025-9-6
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CAMK2A/CaMKII alpha Antibody (6G9) - Western Blotting - Image 380232
CaMKIIα 抗体 (6G9): sc-32288. 人脑 (A), 小鼠小脑 (B) 和人类大脑皮层 (C) 组织提取物中 CaMKIIα 表达的 Western 印迹分析.
CaMKIIα 抗体 (6G9): sc-32288. 人脑 (A), 小鼠小脑 (B) 和人类大脑皮层 (C) 组织提取物中 CaMKIIα 表达的 Western 印迹分析.

CAMK2A/CaMKII alpha 抗体 (6G9): sc-32288

4.3(8)
寫評論提問

说明书
  • CAMK2A/CaMKII alpha抗体(6G9)是小鼠单克隆IgG1 κ, 在19篇文献中引用，规格为200 µg/ml
  • 针对部分纯化的钙调磷酸酶激酶II（rat起源）
  • 抗-CAMK2A/CaMKII alpha 抗体 (6G9) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 CaMKIIα; 不会与 60 kDa β subunit in either phosphorylation site产生交联反应
  • 抗CAMK2A/CaMKII alpha抗体（6G9）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CAMK2A/CaMKII alpha (6G9): sc-32288的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG1 BP-HRP 是 CAMK2A/CaMKII alpha 抗体 (6G9) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与CAMK2A/CaMKII alpha 抗体 (6G9) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 CaMK 抗体 包括 CaMKI, CaMKI δ, CaMKI γ, CaMKII, CaMKII α, CaMKII β, CaMKII δ, CaMKII γ, CaMKIV和CaMKK α

CaMKIIα抗体（6G9）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过应用如蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠和人类样本中的CaMKIIα。抗CaMKIIα抗体（6G9）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。CaMKIIα在细胞信号传导通路中发挥着关键作用，特别是在调节神经元的突触可塑性和记忆形成方面，因此CaMKIIα对于认知功能至关重要。CaMKIIα主要位于细胞质中，激活后可转移到细胞核，这对于调节基因表达和影响细胞对钙信号的反应至关重要。CaMKIIα在细胞质和细胞核中的存在凸显了其在各种生理过程（包括学习和记忆）中的重要性，以及其在神经退行性疾病等病理条件下的参与。CaMKIIα单克隆抗体（6G9）使研究人员能够深入了解这种关键蛋白的功能动态及其在健康和疾病中的意义。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CAMK2A/CaMKII alpha 抗体 (6G9) 参考文献:

  1. 反复服用s-ketamine作为NMDAR拮抗剂具有抗抑郁作用：CUMS小鼠海马中的CaMKIIα和mTOR信号传导参与其中。  |  O'Hara, DA., et al. 1986. Br J Anaesth. 58: 1300-2. PMID: 2877683
  2. 神经孢子菌中昼夜节律对翻译起始因子eIF2α活性的控制需要eIF2γ依赖性节奏PPP-1磷酸酶的招募。  |  Xie, Z., et al. 2018. Cell Death Differ. 25: 1442-1456. PMID: 29352270
  3. 社会挫败会引发小鼠的梨状皮层过度兴奋，从而诱发学习和记忆障碍，但不会引发情绪障碍。  |  Liu, J., et al. 2022. Mol Psychiatry. 27: 2136-2145. PMID: 35079125
  4. 非经典Wnt通过Frizzled 6和DVL-2/B-raf/CaMKIIα/syndecan 4轴诱导软骨细胞去分化。  |  Wang, H., et al. 2022. Transl Psychiatry. 12: 380. PMID: 36088395
  5. 纳米 C60 促进磷酸化 CaMKIIα 的突触分布并改善 APP/PS1 转基因小鼠的认知功能  |  Dai, W., et al. 2022. ACS Chem Neurosci. 13: 3534-3543. PMID: 36441865
  6. 前内侧丘脑核到扣带回皮层的投射介导小鼠的疼痛和焦虑行为。  |  Liu, B., et al. 2023. Brain Res. 1811: 148375. PMID: 37146745
  7. 使用两种麻醉技术比较维库溴铵诱导的神经肌肉阻滞后的视觉和测量的四连针恢复。  |  Ma, Y., et al. 2023. Front Neural Circuits. 17: 1197541. PMID: 37469833
  8. 脊椎动物的综合应激反应由四种eIF2α激酶调节。  |  Hong, J., et al. 2023. Neurochem Int. 171: 105640. PMID: 37951541
  9. TAAR1通过负调节NAc中的CaMKIIα活性来调节药物诱导的可卡因寻求恢复。  |  Gonzalo-Consuegra, C., et al. 2024. Biomed Pharmacother. 174: 116473. PMID: 38522237

订购信息

产品名称产品编号规格价格数量收藏夹

CAMK2A/CaMKII alpha 抗体 (6G9)

sc-32288
200 µg/ml
RMB2377.00

CAMK2A/CaMKII alpha (6G9): m-IgG Fc BP-HRP 套装

sc-526672
200 µg Ab; 10 µg BP
RMB2662.00

CAMK2A/CaMKII alpha (6G9): m-IgG1 BP-HRP 套装

sc-532045
200 µg Ab; 20 µg BP
RMB2662.00

CAMK2A/CaMKII alpha 抗体 (6G9) AC

sc-32288 AC
500 µg/ml, 25% agarose
RMB3129.00

CAMK2A/CaMKII alpha 抗体 (6G9) HRP

sc-32288 HRP
200 µg/ml
RMB2377.00

CAMK2A/CaMKII alpha 抗体 (6G9) FITC

sc-32288 FITC
200 µg/ml
RMB2482.00

CAMK2A/CaMKII alpha 抗体 (6G9) PE

sc-32288 PE
200 µg/ml
RMB2580.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 488

sc-32288 AF488
200 µg/ml
RMB2685.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 546

sc-32288 AF546
200 µg/ml
RMB2685.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 594

sc-32288 AF594
200 µg/ml
RMB2685.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 647

sc-32288 AF647
200 µg/ml
RMB2685.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 680

sc-32288 AF680
200 µg/ml
RMB2685.00

CAMK2A/CaMKII alpha 抗体 (6G9) Alexa Fluor® 790

sc-32288 AF790
200 µg/ml
RMB2685.00

Hello! If the antibody is bought pre-conjugated to one of the Alexa Fluor fluorophore's will it still work with IHC?

Asked by: Katie
Thank you for your question . Yes, Alexa flour conjugated antibodies will work for IHC.
Answered by: BlakeJ
Date published: 2023-11-14

Hola! ¿Me podrían decir por favor frente a que región está dirigido este anticuerpo CaMKIIalfa (6G9)? Muchas gracias.

Asked by: RosP
Gracias por su pregunta. No hemos caracterizado el sitio de unión exacto de CaMKIIα (6G9): sc-32288. Sin embargo, se sabe que reacciona con la subunidad alfa tanto fosforilada como no fosforilada de CaM kinase II. Thank you for your question. We have not characterized the exact binding site of CaMKIIα (6G9): sc-32288. However, it is known to react with both phosphorylated and non-phosphorylated alpha subunit of CaM kinase II.
Answered by: Technical Support
Date published: 2018-12-31

I am using CaMKIIα (6G9): sc-32288 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: jerojero
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by from GoodA band of predicted size was detected in WB (mouse brain lysate).
Date published: 2020-06-26
Rated 4 out of 5 by from Ab funziona bene!Ho testato l'anticorpo (dil. 1:500 come da datasheet, ma potrebbe essere benissimo usato 1:1000) su un lisato proteico di cervelletto murino. L'anticorpo ha riconosciuto in maniera specifica due bande molto vicine (un doppietto) a circa 45-47kDa.
Date published: 2019-03-22
Rated 5 out of 5 by from Excellent AntibodyI tested this antibody on mouse brain lysate, detected a single strong sign
Date published: 2018-07-06
Rated 5 out of 5 by from Great for IHC(P) and WBCaMKIIα (6G9) gave a really nice band at 50 kDa in mouse cerebellum extract: sc-2403.
Date published: 2017-02-03
Rated 4 out of 5 by from We got good staining in IF in mouse cellsWe got good staining in IF in mouse cells with this antibody.
Date published: 2015-09-14
Rated 4 out of 5 by from Published data for WB and IF in monkey brainPublished data for WB and IF in monkey brain sample. -SCBT Publication Review
Date published: 2015-04-28
Rated 4 out of 5 by from Clear band in WB in mouse brain and rat brainClear band in WB in mouse brain and rat brain tissue extracts. -SCBT QC
Date published: 2015-02-24
Rated 4 out of 5 by from Published data for WB in mouse CerebellarPublished data for WB in mouse Cerebellar Purkinje cells. -SCBT Publication Review
Date published: 2015-01-23
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CAMK2A/CaMKII alpha 抗体 (6G9) is rated 4.3 out of 5 by 8.
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