Date published: 2025-9-7

021-6093-6350

SCBT Portrait Logo
Seach Input

CAD 抗体 (F-11): sc-374067

5.0(4)
寫評論提問

说明书
  • CAD 抗体 F-11 是小鼠单克隆 IgG1 κ,CAD抗体, 在7篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的CAD的N-terminus的氨基酸2-29之间
  • CAD 抗体 (F-11) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 CAD
  • 抗CAD抗体(F-11)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取CAD (F-11): sc-374067免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是CAD Antibody (F-11) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与CAD Antibody (F-11) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

CAD抗体(F-11)是一种IgG1 κ小鼠单克隆CAD抗体(也称为CAD抗体),可通过WB、IP、IF和ELISA检测小鼠、大鼠和人类的CAD蛋白。CAD抗体(F-11)既可以是非偶联的抗CAD抗体形式,也可以是多种偶联形式的抗CAD抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。Ced/ICE或半胱氨酸蛋白酶的caspase家族在通过蛋白水解特定靶标来介导细胞凋亡中起关键作用。这些靶标包括聚(ADP-核糖)聚合酶(PARP)、凝胶溶素、ICAD(CAD抑制剂,也称为DFF-45)和核层蛋白。CAD(caspase激活的脱氧核糖核酸酶),也称为CPAN(caspase激活的核酸酶)和DFF40,是一种在细胞凋亡过程中负责DNA降解的DNase。Caspase-3的作用是使CAD从ICAD中解离,允许CAD进入细胞核并降解DNA。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

CAD 抗体 (F-11) 参考文献:

  1. 内切酶G从线粒体释放时是一种凋亡DNA酶。  |  Li, LY., et al. 2001. Nature. 412: 95-9. PMID: 11452314
  2. 脑局部缺血和再灌注后诱导的半胱天冬酶激活的脱氧核糖核酸酶活性。  |  Luo, Y., et al. 2002. J Cereb Blood Flow Metab. 22: 15-20. PMID: 11807389
  3. 紫草素通过激活半胱天冬酶-3和阻断DNA合成来调节HeLa细胞的死亡。  |  Wu, Z., et al. 2004. J Asian Nat Prod Res. 6: 155-66. PMID: 15224412
  4. WEHI-231细胞中B细胞发育过程中DNasegamma的特定阶段表达及其在B细胞受体介导的细胞凋亡中的作用。  |  Shiokawa, D., et al. 2007. Cell Death Differ. 14: 992-1000. PMID: 17218958
  5. Mch3,一种与 CPP32 高度相关的新型人类凋亡半胱氨酸蛋白酶。  |  Fernandes-Alnemri, T., et al. 1995. Cancer Res. 55: 6045-52. PMID: 8521391
  6. Mch2 alpha 而非 CPP32 对层粘蛋白 A 的裂解:多种白细胞介素 1 β-转化酶相关蛋白酶在细胞凋亡过程中具有不同的底物识别特性。  |  Takahashi, A., et al. 1996. Proc Natl Acad Sci U S A. 93: 8395-400. PMID: 8710882
  7. DFF 是一种异源二聚体蛋白,在细胞凋亡过程中,它在 Caspase-3 的下游发挥作用,引发 DNA 断裂。  |  Liu, X., et al. 1997. Cell. 89: 175-84. PMID: 9108473
  8. Caspase-3生成的凝胶蛋白片段:细胞凋亡中形态变化的效应因子。  |  Kothakota, S., et al. 1997. Science. 278: 294-8. PMID: 9323209
  9. Caspases:通过蛋白水解在细胞内传递信号。  |  Salvesen, GS. and Dixit, VM. 1997. Cell. 91: 443-6. PMID: 9390553
  10. 一种在细胞凋亡过程中降解 DNA 的由 Caspase 激活的 DNase 及其抑制剂 ICAD。  |  Enari, M., et al. 1998. Nature. 391: 43-50. PMID: 9422506
  11. 在细胞凋亡过程中,CAD 抑制剂在 CAD 激活和 DNA 降解过程中发生裂解。  |  Sakahira, H., et al. 1998. Nature. 391: 96-9. PMID: 9422513
  12. CPAN,一种受树突酶敏感抑制剂 DFF45 调节的人类核酸酶。  |  Halenbeck, R., et al. 1998. Curr Biol. 8: 537-40. PMID: 9560346

订购信息

产品名称产品编号规格价格数量收藏夹

CAD 抗体 (F-11)

sc-374067
200 µg/ml
RMB2377.00

CAD (F-11): m-IgG Fc BP-HRP 套装

sc-529649
200 µg Ab; 10 µg BP
RMB2662.00

CAD (F-11): m-IgGκ BP-HRP 套装

sc-522606
200 µg Ab, 40 µg BP
RMB2662.00

CAD (F-11): m-IgG1 BP-HRP 套装

sc-543622
200 µg Ab; 20 µg BP
RMB2662.00

CAD 抗体 (F-11) AC

sc-374067 AC
500 µg/ml, 25% agarose
RMB3129.00

CAD 抗体 (F-11) HRP

sc-374067 HRP
200 µg/ml
RMB2377.00

CAD 抗体 (F-11) FITC

sc-374067 FITC
200 µg/ml
RMB2482.00

CAD 抗体 (F-11) PE

sc-374067 PE
200 µg/ml
RMB2580.00

CAD 抗体 (F-11) Alexa Fluor® 488

sc-374067 AF488
200 µg/ml
RMB2685.00

CAD 抗体 (F-11) Alexa Fluor® 546

sc-374067 AF546
200 µg/ml
RMB2685.00

CAD 抗体 (F-11) Alexa Fluor® 594

sc-374067 AF594
200 µg/ml
RMB2685.00

CAD 抗体 (F-11) Alexa Fluor® 647

sc-374067 AF647
200 µg/ml
RMB2685.00

CAD 抗体 (F-11) Alexa Fluor® 680

sc-374067 AF680
200 µg/ml
RMB2685.00

CAD 抗体 (F-11) Alexa Fluor® 790

sc-374067 AF790
200 µg/ml
RMB2685.00

CAD (F-11) 中和勝肽

sc-374067 P
100 µg/0.5 ml
RMB511.00

What application is the blocking peptide sc-374067 P appropriate for?

Asked by: jerojero
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
  • y_2025, m_8, d_31, h_8CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_374067, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 102ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from opinions about antibodiesVery good antibodies, work at delal dilutions, no non-specific binding
Date published: 2023-05-24
Rated 5 out of 5 by from good featuresI applied for the samples several days ago and they gave it to me immediately. very good and sensitive.
Date published: 2018-01-31
Rated 5 out of 5 by from Great immunofluorescence nuclear and cytoplasmicGreat immunofluorescence nuclear and cytoplasmic staining in methanol-fixed HeLa cells. -SCBT QC
Date published: 2015-04-29
Rated 5 out of 5 by from Nice Western Blot data of CAD expression in KNice Western Blot data of CAD expression in K-562 and Jurkat nuclear extracts. -SCBT QC
Date published: 2014-03-28
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_zh_CN, sid_374067, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
CAD 抗体 (F-11) is rated 5.0 out of 5 by 4.
  • y_2025, m_8, d_31, h_8
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_4
  • loc_zh_CN, sid_374067, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 110ms
  • REVIEWS, PRODUCT