Date published: 2025-9-8
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C5b-9 抗体 (aE11): sc-58935

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说明书
  • C5b-9 抗体 aE11 是小鼠单克隆 IgG2a, 在33篇文献中引用，提供 100 µg/ml
  • 针对纯化的C5b-9 human 起源
  • 推荐用于 human 和 porcine 来源的a neoepitope exposed in C9 when incorporated into C5b-9 in both membrane bound (MAC) and fluid phase (SC5b-9) complexes IF 和 ELISA检测; 不建议用于检测the native components
  • 关于如何获取C5b-9 (aE11): sc-58935的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP、 2a BP-HRP">m-IgG2a BP-HRP和m-IgGκ BP-HRP是C5b-9 Antibody (aE11). 的首选辅助检测试剂。这些试剂现与C5b-9 Antibody (aE11) 打包提供（请参阅下面的订购信息）。

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描述
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研究信息

関連項目

附加C5抗体，包括C5a

C5b-9抗体（aE11）是一种IgG2a κ小鼠单克隆C5b-9抗体（也称为C5b-9抗体或补体成分5b-9抗体），可通过免疫荧光（IF）和酶联免疫吸附试验（ELISA）检测人源膜结合（MAC）和液相（SC5b-9）复合物中C9掺入C5b-9时暴露的新表位。C5b-9抗体（aE11）可作为非偶联抗C5b-9抗体形式提供。补体成分蛋白：C2、C3、C4和C5是在补体激活过程中释放的强效过敏毒素。这些蛋白与其各自的G蛋白偶联受体C3aR、C1R和C5aR结合，可诱导促炎事件，如细胞脱粒、平滑肌收缩、花生四烯酸代谢、细胞因子释放、白细胞活化和细胞趋化性。补体系统的激活导致C5b-9终端复合物的形成，虽然C5b-9可以促进细胞裂解，但C5b-9在细胞膜上的亚溶解性组装会产生相反的结果，并诱导细胞周期激活和存活。C5b-9可以通过PI 3-K信号调节caspase-8的加工，从而挽救少突胶质细胞免于FAS介导的凋亡。C5b-9可能在多发性硬化的急性期发挥促炎作用，但在疾病的慢性期也可能具有神经保护作用。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

C5b-9 抗体 (aE11) 参考文献:

  1. 补体 C5b-9 可诱导肾小球上皮细胞中受体酪氨酸激酶的转录活化。  |  Cybulsky, AV., et al. 1999. Am J Pathol. 155: 1701-11. PMID: 10550326
  2. 亚溶解 C5b-9 对少突胶质细胞凋亡的抑制与 bcl-2 合成的增强有关，并通过抑制 caspase-3 的活化来实现。  |  Soane, L., et al. 1999. J Immunol. 163: 6132-8. PMID: 10570303
  3. 特发性膜性肾病的肾脏 C3 合成：与尿液 C5b-9 排泄的相关性。  |  Montinaro, V., et al. 2000. Kidney Int. 57: 137-46. PMID: 10620195
  4. 格林-巴利综合征周围神经中细胞因子, C5b-9 和 ICAM-1 的免疫组化定域。  |  Putzu, GA., et al. 2000. J Neurol Sci. 174: 16-21. PMID: 10704976
  5. C5b-9末端补体复合物通过磷脂酰肌醇3-激酶/Akt途径调节Bad，保护少突胶质细胞免于死亡。  |  Soane, L., et al. 2001. J Immunol. 167: 2305-11. PMID: 11490019
  6. 亚溶解的 C5b-9 通过 PI 3-kinase 介导的 BAD 磷酸化刺激许旺细胞存活。  |  Hila, S., et al. 2001. Glia. 36: 58-67. PMID: 11571784
  7. 自身免疫性脱髓鞘和多发性硬化症中的 C5b-9 补体复合物：在神经炎症和神经保护中的双重作用。  |  Rus, H., et al. 2005. Ann Med. 37: 97-104. PMID: 16026117
  8. 补体 C5b-9 复合物通过增加一氧化氮的合成诱导 Thy-1 肾炎大鼠肾小球系膜细胞损伤。  |  Wang, Y., et al. 2006. Life Sci. 79: 182-92. PMID: 16458938
  9. C5b-9 末端复合体通过抑制 caspase-8 处理和上调 FLIP，保护少突胶质细胞免于凋亡。  |  Cudrici, C., et al. 2006. J Immunol. 176: 3173-80. PMID: 16493077

订购信息

产品名称产品编号规格价格数量收藏夹

C5b-9 抗体 (aE11)

sc-58935
100 µg/ml
RMB2377.00

C5b-9 (aE11): m-IgG Fc BP-HRP 套装

sc-537157
100 µg Ab; 10 µg BP
RMB2662.00

C5b-9 (aE11): m-IgGκ BP-HRP 套装

sc-534353
100 µg Ab; 40 µg BP
RMB2662.00

C5b-9 (aE11): m-IgG2a BP-HRP 套装

sc-547936
100 µg Ab; 10 µg BP
RMB2662.00

Do you have similar antibody for mouse?

Asked by: Vishal
Thank you for your question. sc-66190 C5b-9 Antibody (2A1) has been recommended for mouse and rat. https://www.scbt.com/p/c5b-9-antibody-2a1
Answered by: BlakeJ
Date published: 2023-07-06

Hi, May I request the MSDS and COA for the anti C5b-9 antibody. Cat# of the antibody is 'sc-58935', and Lot# is 'C1522'. If you have the documents, could you please provide them to me?

Asked by: yonge
Thank you for your question. There is no MSDS or CoA for antibodies.
Answered by: Technical Service SH
Date published: 2023-03-22

Does this antibody binds with monkey C5b9 complex?

Asked by: Jimit
Thank you for your question. This antibody has not yet been tested in monkey and so that is not a recommended species at this time. We are still gathering data to show on our website. Check back for updates!
Answered by: Dallas Tech Service
Date published: 2021-03-18

Can C5b-9（aE11）sc-58935 be used in IHC(P) ?

Asked by: weijia
Thank you for your question. This antibody has not been tested for IHC(P), so we can not recommend or warranty it for that use. It is, however, recommended for IHC on fresh frozen tissue samples.
Answered by: Tech Service
Date published: 2019-01-21

What is the total volume provided of C5b-9 (aE11): sc-58935 monoclonal antibody?

Asked by: jenni
Each vial of C5b-9 (aE11): sc-58935 monoclonal antibody contains 100 µg IgG2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Answered by: Technical Support 4
Date published: 2017-01-17
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Rated 4 out of 5 by from Good antibodyIts very stable and easy to use in ELISA and flow cytometry
Date published: 2024-08-13
Rated 5 out of 5 by from Consistent and reliable antibodyThis antibody works very well for immunocytochemistry
Date published: 2023-03-13
Rated 5 out of 5 by from Good AntibodyC5b-9 (aE11) is cited for Immunofluorescence (IF). Recommend frozen sections.
Date published: 2017-01-13
Rated 5 out of 5 by from Publishable WB data with rat GMCsPublishable WB data with rat GMCs - SCBT Publication Review
Date published: 2015-02-15
Rated 5 out of 5 by from IF publishable data with human renal glomerularIF publishable data with human renal glomerular endothelial cells (HRGECs) - SCBT Publication Review
Date published: 2013-05-29
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C5b-9 抗体 (aE11) is rated 4.8 out of 5 by 5.
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