Date published: 2025-9-8

021-6093-6350

SCBT Portrait Logo
Seach Input

C3G 抗体 (G-9): sc-393836

5.0(2)
寫評論提問

说明书
  • C3G抗体(G-9)是小鼠单克隆IgG2b κ, 在2篇文献中引用,规格为200 µg/ml
  • 特异性抗原位于human物种的C3G的C-terminus附近的氨基酸1010-1039之间
  • 推荐用于 mouse, rat 和 human 来源的C3G WB, IP, IF 和 ELISA检测
  • 2b BP-HRP">m-IgG2b BP-HRPm-IgGκ BP-HRP是C3G Antibody (G-9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与C3G Antibody (G-9) 打包提供(请参阅下面的订购信息)。

快捷链接

関連項目

Ras p21是GTP酶超家族的原型,参与多种细胞过程的调节。Ras信号以GTP结合的形式存在,但当结合GDP时"关闭"。当不受调节或因突变而持续开启时,Ras信号导致恶性转化。活性与非活性Ras之间的转换由GTP酶激活蛋白(GAP)和鸟嘌呤核苷交换因子(GEF)控制。C3G是在筛选可结合Crk原癌基因产物SH3结构域的蛋白质时分离出来的。C3G蛋白的羧基末端与Ras-GRF/Cdc25Mm和mSos具有显著的序列相似性,可以在酿酒酵母中替代Cdc25功能。这些观察结果强烈表明C3G是Ras的GEF,并通过Crk参与Ras信号的调节。C3G基因定位于人类染色体9q34.13,靠近编码c-Abl的基因,c-Abl是一种调节Crk的原癌基因。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

C3G 抗体 (G-9) 参考文献:

  1. C3G 过表达可通过 p-ERK1/2 促进大鼠 H9C2 心肌细胞的存活。  |  Zhang, X., et al. 2013. Cell Biol Int. 37: 1106-13. PMID: 23686869
  2. C3G/Rap1 通路促进 MMP-2 和 MMP-9 的分泌,并参与浆液性卵巢癌的转移。  |  Che, YL., et al. 2015. Cancer Lett. 359: 241-9. PMID: 25617801
  3. 通过增加 Rap1 介导的 p38α 激活,C3G 基因敲除可增强肿瘤的迁移和侵袭,而通过 p38α 的非依赖性机制,C3G 基因敲除可损害肿瘤的生长。  |  Priego, N., et al. 2016. Oncotarget. 7: 45060-45078. PMID: 27286263
  4. C3G 与核斑点动态结合,并调节 mRNA 的剪接。  |  Shakyawar, DK., et al. 2018. Mol Biol Cell. 29: 1111-1124. PMID: 29496966
  5. 沉默 C3G 可通过调节 p-ERK1/2 和 Bax 增加心肌细胞存活抑制和凋亡。  |  Yang, D., et al. 2019. Clin Exp Pharmacol Physiol. 46: 237-245. PMID: 30152875
  6. C3G 以 cenexin 依赖性方式定位到母中心粒,并调节中心体的复制和初级纤毛的长度。  |  Nayak, SC. and Radha, V. 2020. J Cell Sci. 133: PMID: 32371504
  7. 淋巴瘤中 GTP 酶 Rap1 激活剂 C3G 的自动调节机制及其催化失调。  |  Carabias, A., et al. 2020. Sci Signal. 13: PMID: 32873726
  8. C3G 可调控 STAT3、ERK 和粘附信号转导,对胚胎干细胞的分化至关重要。  |  Vishnu, VV., et al. 2021. Stem Cell Rev Rep. 17: 1465-1477. PMID: 33624208
  9. C3G 下调会诱导胶质母细胞瘤细胞获得间充质表型,从而增强其侵袭性。  |  Manzano, S., et al. 2021. Cell Death Dis. 12: 348. PMID: 33824275
  10. 扁豆蛋白隔离物(LPI)与花青素-3-O-葡萄糖苷(C3G)的相互作用特征及其对 C3G 的稳定性和抗氧化活性的影响  |  Qian, H., et al. 2022. Foods. 12: PMID: 36613320

订购信息

产品名称产品编号规格价格数量收藏夹

C3G 抗体 (G-9)

sc-393836
200 µg/ml
$316.00

C3G (G-9): m-IgGκ BP-HRP 套装

sc-535903
200 µg Ab; 40 µg BP
$354.00

C3G (G-9): m-IgG2b BP-HRP 套装

sc-549486
200 µg Ab; 10 µg BP
$354.00

C3G (G-9) 中和勝肽

sc-393836 P
100 µg/0.5 ml
$68.00

What application is the blocking peptide sc-393836 P appropriate for?

Asked by: jerojero
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-27
  • y_2025, m_8, d_30, h_9CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_zh_CN, sid_393836, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getContent, 113ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Specificity of this mono is excellentSpecificity of this mono is excellent. Single strong band in CRISPR control and complete knockout in sc-401616 transfected Hek 293T cells. -SCBT QC
Date published: 2015-03-22
Rated 5 out of 5 by from Great Western blot dataGreat Western blot data, detects endgenous C3G in K-562 and Jurkat whole cell lysates. -SCBT QC
Date published: 2015-02-05
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_393836, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
C3G 抗体 (G-9) is rated 5.0 out of 5 by 2.
  • y_2025, m_8, d_30, h_9
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_2
  • loc_zh_CN, sid_393836, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-4.0.0
  • CLOUD, getAggregateRating, 102ms
  • REVIEWS, PRODUCT