Date published: 2026-10-24

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c-Fms/CSF-1R Antibody (D-8) - Immunofluorescence - Image 298964
c-Fms/CSF-1R 抗体 (D-8): sc-365719. 福尔马林固定的 Hep G2 细胞免疫荧光染色, 显示膜定位.
c-Fms/CSF-1R 抗体 (D-8): sc-365719. 福尔马林固定的 Hep G2 细胞免疫荧光染色, 显示膜定位.

c-Fms/CSF-1R 抗体 (D-8): sc-365719

3.8(6)
寫評論提問
说明书
  • c-Fms/CSF-1R抗体(D-8)是小鼠单克隆IgG1 κ, 在6篇文献中引用，规格为200 µg/ml
  • 特异性抗原位于human物种的c-Fms/CSF-1R的C-terminus的氨基酸943-971之间
  • 抗-c-Fms/CSF-1R 抗体 (D-8) 推荐用于 WB, IP, IF, IHC(P) 和 ELISA，检测mouse, rat 和human 来源的 c-Fms/CSF-1R; 也和以下物种反应，包括： bovine
  • 抗c-Fms/CSF-1R抗体（D-8）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP是c-Fms/CSF-1R Antibody (D-8) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与c-Fms/CSF-1R Antibody (D-8) 搭配使用（请参阅下面的订购信息）。
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関連項目

c-Fms/CSF-1R抗体（D-8）是一种IgG1 κ小鼠单克隆c-Fms/CSF-1R抗体，可通过WB、IP、IF、IHC(P)和ELISA检测小鼠、大鼠和人类的c-Fms/CSF-1R。c-Fms/CSF-1R抗体（D-8）既可作为非偶联抗c-Fms/CSF-1R抗体形式，也可作为多种偶联形式的抗c-Fms/CSF-1R抗体，包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor偶联物。c-Fms/CSF-1R，也称为巨噬细胞集落刺激因子受体（M-CSFR）、FIM2或CD115，是一种属于CSF1/PDGF受体家族的跨膜酪氨酸激酶受体。它由c-Fms原癌基因编码，并在单核吞噬细胞、卵母细胞、蜕膜细胞、滋养层细胞和一些成肌细胞中表达。它对髓系细胞的生长和分化至关重要，其功能可由SLAP-2调节。c-Fms/CSF-1R负责介导M-CSF的所有功能。M-CSF是一种糖蛋白，对单核吞噬细胞（包括破骨细胞）的增殖和分化至关重要。同时，M-CSF也被认为是炎症反应的重要介质，可以调节巨噬细胞中促炎细胞因子的释放。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

c-Fms/CSF-1R 抗体 (D-8) 参考文献:

  1. 肝细胞癌中c-fms癌基因的点突变与异常表达之间的关系。  |  Yang, DH., et al. 2004. Hepatobiliary Pancreat Dis Int. 3: 86-9. PMID: 14969845
  2. cAMP抑制CSF-1刺激的酪氨酸磷酸化，但增强CSF-1R介导的巨噬细胞分化和ERK激活。  |  Wilson, NJ., et al. 2005. FEBS J. 272: 4141-52. PMID: 16098196
  3. JNK对巨噬细胞的发展和存活至关重要。  |  Himes, SR., et al. 2006. J Immunol. 176: 2219-28. PMID: 16455978
  4. ABT-869和其他酪氨酸激酶抑制剂抑制转染细胞中集落刺激因子-1受体（c-Fms）酪氨酸激酶的磷酸化。  |  Guo, J., et al. 2006. Mol Cancer Ther. 5: 1007-13. PMID: 16648572
  5. 小鼠中性粒细胞表达编码巨噬细胞集落刺激因子受体（CSF-1R）的 mRNA 以及许多其他巨噬细胞特异性转录本，并能在 CSF-1 的作用下体外转分化为巨噬细胞。  |  Sasmono, RT., et al. 2007. J Leukoc Biol. 82: 111-23. PMID: 17438263
  6. 集落刺激因子-1和集落刺激因子-1受体的共同表达与胃癌的疾病进展有关。  |  Okugawa, Y., et al. 2018. Int J Oncol. 53: 737-749. PMID: 29767252
  7. M-CSFR抑制剂在成人T细胞白血病/淋巴瘤中的潜在抗淋巴瘤作用。  |  Komohara, Y., et al. 2018. J Clin Exp Hematop. 58: 152-160. PMID: 30541986
  8. 巨噬细胞中的CSF-1和细胞周期控制。  |  Hamilton, JA. 1997. Mol Reprod Dev. 46: 19-23. PMID: 8981359
  9. 正常哺乳期乳腺上皮细胞表达CSF-I和CSF-I受体。  |  Sapi, E., et al. 1998. J Soc Gynecol Investig. 5: 94-101. PMID: 9509388
  10. CSF-1在正常和肿瘤性乳腺生理学中的作用。  |  Sapi, E. and Kacinski, BM. 1999. Proc Soc Exp Biol Med. 220: 1-8. PMID: 9893162

订购信息

产品名称产品编号规格价格数量收藏夹

c-Fms/CSF-1R 抗体 (D-8)

sc-365719
200 µg/ml
CNY2422.00

c-Fms/CSF-1R (D-8): m-IgG Fc BP-HRP 套装

sc-525897
200 µg Ab; 10 µg BP
CNY2715.00

c-Fms/CSF-1R 抗体 (D-8) AC

sc-365719 AC
500 µg/ml, 25% agarose
CNY3189.00

c-Fms/CSF-1R 抗体 (D-8) HRP

sc-365719 HRP
200 µg/ml
CNY2422.00

c-Fms/CSF-1R 抗体 (D-8) FITC

sc-365719 FITC
200 µg/ml
CNY2527.00

c-Fms/CSF-1R 抗体 (D-8) PE

sc-365719 PE
200 µg/ml
CNY2625.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 488

sc-365719 AF488
200 µg/ml
CNY2738.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 546

sc-365719 AF546
200 µg/ml
CNY2738.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 594

sc-365719 AF594
200 µg/ml
CNY2738.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 647

sc-365719 AF647
200 µg/ml
CNY2738.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 680

sc-365719 AF680
200 µg/ml
CNY2738.00

c-Fms/CSF-1R 抗体 (D-8) Alexa Fluor® 790

sc-365719 AF790
200 µg/ml
CNY2738.00

c-Fms/CSF-1R (D-8) 中和勝肽

sc-365719 P
100 µg/0.5 ml
CNY519.00

Buongionro, vedo scritto che c-Fms/CSF-1R (D-8): sc-365719 contiene IgG light chain. Che significa? L'anticorpo è costituito solamente dalla light chain e non c'e' heavy chain? Grazie

Asked by: Luisa
Thank you for your question. This is a complete 150 kDa mouse IgG1 antibody consisting of heavy chain and kappa light chain. We indicate whether our antibodies possess a kappa or lambda light chain for the purpose of secondary detection.
Answered by: Tech Support Europe
Date published: 2025-04-10

Dose this antibody can be used spinal of rat?

Asked by: cmuguanguan
Thank you for your question. Anti-c-Fms/CSF-1R Antibody (D-8) is recommended for detection of c-Fms/CSF-1R of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA and would work in these assays with spinal samples from rat.
Answered by: Tech Support Europe
Date published: 2021-02-08

Does this antibody block CSF-1R activation?

Asked by: karel
Thank you for your question. This antibody has not been tested for blocking applications, so we do not have any information regarding its use for that purpose. Please contact Technical Service by phone, (800)-457-3801 option 2, email <[email protected]>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Tech Service
Date published: 2017-04-24

What application is the blocking peptide sc-365719 P appropriate for?

Asked by: DefinitelyNotMatt
Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
Answered by: Technical Support
Date published: 2017-02-24
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Rated 4 out of 5 by HAOHAO from Good antibodyマウスの肺組織でウェスタンブロットのシングルバンドが良く出ました。他に良い抗体がみつからなかったので、助かりました。
Date published: 2023-09-24
Rated 2 out of 5 by hhwoo from so, sothis ab detects 3 bands, 70, 100, 130 kDa in breast and ovarian cancer cells.
Date published: 2017-04-21
Rated 5 out of 5 by JL from Published WB data with mouse samplesPublished WB data with mouse samples - SCBT Publication Review
Date published: 2015-04-29
Rated 4 out of 5 by ET from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
Date published: 2015-02-23
Rated 3 out of 5 by SH from Robust band seen in WB using THPRobust band seen in WB using THP-1 whole cell lysate. -SCBT QC
Date published: 2015-01-04
Rated 5 out of 5 by MS from Produced beautiful immunofluorescence membraneProduced beautiful immunofluorescence membrane staining in formalin-fixed HepG2 cells. -SCBT QC
Date published: 2013-10-13
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c-Fms/CSF-1R 抗体 (D-8) is rated 3.8 out of 5 by 6.
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