Date published: 2025-9-7

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BTG2 抗体 (1A5): sc-517187

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说明书
  • BTG2 抗体 1A5 是小鼠单克隆 IgG1 κ,BTG2抗体, 在5篇文献中引用,规格为100 µg/ml
  • 针对氨基酸59-158的抗原,代表human起源的部分重组BTG2蛋白
  • 推荐用于 human 来源的BTG2 WB, IP 和 ELISA检测
  • 关于如何获取BTG2 (1A5): sc-517187免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是BTG2 Antibody (1A5) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与BTG2 Antibody (1A5) 打包提供(请参阅下面的订购信息)。

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関連項目

BTG2抗体(1A5)是一种小鼠单克隆IgG1 kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)和酶联免疫吸附测定(ELISA)检测人类来源的BTG2蛋白。抗BTG2抗体(1A5)可作为非结合单克隆同种型抗体使用。BTG2是B细胞易位基因家族的重要成员,在调节细胞增殖和转录方面发挥着重要作用。BTG2是一种p53诱导蛋白,可作为抗增殖因子,尤其影响细胞周期的G1/S转换。BTG2的表达会因DNA损伤和生长刺激等各种细胞应激反应而增加,这凸显了BTG2在维持细胞完整性和调节细胞周期方面的重要性。BTG2在肾脏近端小管、肺泡支气管上皮和前列腺腺泡基底细胞层等关键组织中的含量较高,表明BTG2在这些器官中发挥着重要作用。BTG2含有LXXLL结构域,这是与核受体相互作用所必需的,进一步强调了BTG2在转录调控中的参与。BTG2能够调节细胞周期进展并响应细胞信号,这使其成为癌症研究和治疗开发中的重要蛋白。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

BTG2 抗体 (1A5) 参考文献:

  1. 抗增殖蛋白 BTG1 和 BTG2 与 CAF1(酵母 CCR4 转录复合体的一个组成部分的人类同源物)的关系:参与雌激素受体 alpha 信号通路。  |  Prévôt, D., et al. 2001. J Biol Chem. 276: 9640-8. PMID: 11136725
  2. PC3/BTG/TOB家族的原型成员PC3(TIS21/BTG2)基因:控制细胞生长, 分化和DNA修复的调节器?  |  Tirone, F. 2001. J Cell Physiol. 187: 155-65. PMID: 11267995
  3. 人类 BTG2/TIS21/PC3 基因:基因组结构, 转录调控和作为候选肿瘤抑制基因的评估。  |  Duriez, C., et al. 2002. Gene. 282: 207-14. PMID: 11814693
  4. 正常人体组织中 B 细胞易位基因 2 蛋白的表达。  |  Melamed, J., et al. 2002. Tissue Cell. 34: 28-32. PMID: 11989967
  5. BTG2 抗增殖蛋白以三种细胞周期调控形式与体内存在的人类 CCR4 复合物相互作用。  |  Morel, AP., et al. 2003. J Cell Sci. 116: 2929-36. PMID: 12771185
  6. BTG1,一个新的抗增殖基因家族成员。  |  Rouault, JP., et al. 1992. EMBO J. 11: 1663-70. PMID: 1373383
  7. 细胞周期调节因子 BTG2 的表达受损在透明细胞肾细胞癌中很常见。  |  Struckmann, K., et al. 2004. Cancer Res. 64: 1632-8. PMID: 14996721
  8. TIS21/BTG2/PC3 通过 PKC-delta 途径表达,抑制细胞周期蛋白 B1-Cdc2 的结合及其活性,与 p53 的表达无关。  |  Ryu, MS., et al. 2004. Exp Cell Res. 299: 159-70. PMID: 15302583
  9. NF-kappaB响应基因BTG2的表达在乳腺癌中受到异常调控。  |  Kawakubo, H., et al. 2004. Oncogene. 23: 8310-9. PMID: 15378000
  10. 鉴定 DNA 损伤细胞反应途径中依赖 p53 的抗增殖成分 BTG2。  |  Rouault, JP., et al. 1996. Nat Genet. 14: 482-6. PMID: 8944033

订购信息

产品名称产品编号规格价格数量收藏夹

BTG2 抗体 (1A5)

sc-517187
100 µg/ml
RMB2377.00

BTG2 (1A5): m-IgG Fc BP-HRP 套装

sc-538839
100 µg Ab; 10 µg BP
RMB2662.00

BTG2 (1A5): m-IgGκ BP-HRP 套装

sc-536518
100 µg Ab; 40 µg BP
RMB2662.00

BTG2 (1A5): m-IgG1 BP-HRP 套装

sc-545902
100 µg Ab; 20 µg BP
RMB2662.00

Has it been tested in mice?

Asked by: Ross
Thank you for your question. Based on our tests, we recommend this antibody only for detection of BTG2 of human origin by WB, IP and ELISA.
Answered by: Tech Support Europe
Date published: 2024-10-08

Please could I have a free sample to assess this 1A5 antibody..? Actually, I need to detect BTG2 in mouse samples (WB) and due to general replacement of your old BTG2 antibodies we thus cannot use any antibody for this species...

Asked by: ygosmain
Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody.
Answered by: Technical Support
Date published: 2018-11-30

BTG2 (1A5): sc-517187の無料の10 µgサンプルを送付いただけますでしょうか。

Asked by: ksuzuki
お問い合わせいただき、誠にありがとうございます。 お手数ですが、このサンプルを受け取るには日本での代理店をご連絡ください。 代理店は下記の四社となります。 https://www.scbt.com/scbt/resources/distributors その他の不明点等がございましたら、またご連絡ください。
Answered by: Technical Support 8
Date published: 2017-12-25

For Western Blot, is it recommended to use denatured or non-denatured conditions with BTG2 (1A5): sc-517187 antibody?

Asked by: Professor Griffin
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good specificity in Western BlotThis antibody detects over-expressed human BTG2 in a transfected lysate. -SCBT QC
Date published: 2023-09-14
Rated 5 out of 5 by from Excellent for WBGot free sample to test in mouse primary myoblast with BTG2 overexpression. WB shows clear and specific band for this antibody. Strong recommendation.
Date published: 2018-03-07
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BTG2 抗体 (1A5) is rated 5.0 out of 5 by 2.
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