Date published: 2025-9-6

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β-defensin 2 抗体 (2-RY8): sc-134314

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说明书
  • beta-defensin 2 抗体 2-RY8 是小鼠单克隆 IgG1 (kappa轻链),β-defensin 2抗体,规格为100 µg/ml
  • 针对部分重组片段β-defensin 2(源自human)
  • 推荐用于 human 来源的β-defensin 2 WB, IP 和 ELISA检测
  • 关于如何获取β-defensin 2 (2-RY8): sc-134314免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • 目前,我们还没有完成β-defensin 2 抗体 (2-RY8)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    β-防御素2抗体(2-RY8)是一种IgG1 κ小鼠单克隆β-防御素2抗体(也称为β-防御素2抗体或BD-2抗体),可通过蛋白质印迹法、免疫沉淀法和酶联免疫吸附法检测人源的β-防御素2蛋白。β-防御素2抗体(2-RY8)可作为非偶联抗β-防御素2抗体提供。β-防御素(也称为BD,在人类中为hBD)是具有广谱抗菌活性的小阳离子肽。β-防御素在多种物种的粘膜上皮和中性粒细胞中产生,并受发育调控。人类β-防御素2受炎症局部调节,是第一个可通过炎症局部诱导产生的β-防御素家族成员。人类β-防御素2的小鼠同源物被称为β-防御素3,存在于呼吸系统中,并在肠道和肺的上皮细胞中以低水平存在。独特的鼠β-防御素2(Defb2)在未处理小鼠的气道中不表达,但可被脂多糖在气道中上调,并可能有助于气道粘膜表面的宿主防御。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    β-defensin 2 抗体 (2-RY8) 参考文献:

    1. 小鼠 beta-defensin 3 是一种在多个器官上皮中表达的诱导性抗菌肽。  |  Bals, R., et al. 1999. Infect Immun. 67: 3542-7. PMID: 10377137
    2. β-防御素:通过树突状细胞和 T 细胞 CCR6 连接先天性免疫和适应性免疫。  |  Yang, D., et al. 1999. Science. 286: 525-8. PMID: 10521347
    3. 人β-防御素2在前列腺中的表达。  |  Kim, HJ., et al. 2011. BJU Int. 107: 144-9. PMID: 20575976
    4. 慢性牙周炎患者中人类β-防御素2和蛋白酶激活受体-2的表达。  |  Pereira, AL., et al. 2012. Arch Oral Biol. 57: 1609-14. PMID: 22647427
    5. 原发性硬化性胆管炎中的人类β-防御素2。  |  Chang, C., et al. 2017. Clin Transl Gastroenterol. 8: e80. PMID: 28300822
    6. 健康大鼠呼吸道中β-防御素1和β-防御素2分布的免疫组织化学研究。  |  Masuda, N., et al. 2018. J Vet Med Sci. 80: 395-404. PMID: 29311494
    7. 人β-防御素2通过磷脂酰肌醇4,5-双磷酸介导的膜渗透作用杀死白色念珠菌。  |  Järvå, M., et al. 2018. Sci Adv. 4: eaat0979. PMID: 30050988
    8. 不同喂养方式的早产儿粪便中人类β-防御素-2(hBD-2)水平和肠道菌群模式。  |  Corebima, BIRV., et al. 2019. Iran J Microbiol. 11: 151-159. PMID: 31341570
    9. 人类气道上皮细胞表达一种乙型防御素。  |  McCray, PB. and Bentley, L. 1997. Am J Respir Cell Mol Biol. 16: 343-9. PMID: 9070620
    10. 人类 beta-defensin-1 和 alpha-defensin 由相邻的基因编码:两个具有不同二硫拓扑结构的肽家族有着共同的祖先。  |  Liu, L., et al. 1997. Genomics. 43: 316-20. PMID: 9268634
    11. 人类 beta-defensin HBD-2 基因的结构和图谱及其在炎症部位的表达。  |  Liu, L., et al. 1998. Gene. 222: 237-44. PMID: 9831658
    12. 一种新型小鼠β防御素Defb2在脂多糖作用下会在气道中上调。  |  Morrison, GM., et al. 1999. FEBS Lett. 442: 112-6. PMID: 9923615

    订购信息

    产品名称产品编号规格价格数量收藏夹

    β-defensin 2 抗体 (2-RY8)

    sc-134314
    100 µg/ml
    $333.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with β-defensin 2 (2-RY8): sc-134314 antibody?

    Asked by: AbPolly
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-03-27
    • y_2025, m_8, d_31, h_8CST
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    Rated 5 out of 5 by from Specific for β-defensin 2 in Western BlotThis antibody detects over-expressed human β-defensin 2 in a transfected lysate. -SCBT QC
    Date published: 2023-09-14
    Rated 1 out of 5 by from IHC Assay Review for Beta-Defensin-2 mABApplication: Immunohistochemistry. Protocol: Standard protocol for saliva smear staining. Dilutions tested: 1:10, 1:30, 1:90, 1:270. Results: Specific stain not detected even at dilution factor of 10.
    Date published: 2017-08-31
    Rated 5 out of 5 by from western blot detectionIt worked with succes for western blot detect β-defensin 2,WB 1:1000,The samples were 293T cells,the band at 5kda.Recommend use 15% SDS-PAGE,since the MW is low.
    Date published: 2017-08-12
    Rated 5 out of 5 by from Western blotWestern blot detection of good human cells, WB diluted 1:1000 clear band.
    Date published: 2017-05-24
    Rated 3 out of 5 by from Worked well with transfected lysate by WBWorked well with transfected lysate by WB -SCBT QC
    Date published: 2013-04-19
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    β-defensin 2 抗体 (2-RY8) is rated 3.8 out of 5 by 5.
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