Date published: 2026-10-20

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β-Amyloid 抗体 (20.1): sc-53822

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说明书
  • β-Amyloid抗体(20.1)是小鼠单克隆IgG2b κ, 在15篇文献中引用,规格为200 µg/ml
  • 免疫human物种的β-Amyloid的氨基酸1-40
  • beta-Amyloid 抗体 (20.1) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 APP and β-Amyloid
  • 抗beta-Amyloid抗体(20.1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • m-IgG Fc BP-HRP是β-Amyloid Antibody (20.1) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。该试剂现与β-Amyloid Antibody (20.1) 搭配使用(请参阅下面的订购信息)。
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関連項目

β-淀粉样蛋白抗体(20.1)是一种小鼠单克隆 IgG2b kappa 轻链抗体,可通过免疫印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)、石蜡包埋切片免疫组织化学(IHCP)和酶联免疫吸附试验(ELISA)检测人源的β-淀粉样蛋白。β-淀粉样蛋白(20.1)抗体有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种 Alexa Fluor® 选项。β-淀粉样蛋白是由淀粉样前体蛋白(APP)经蛋白酶裂解产生的,在阿尔茨海默病的发病机制中起着关键作用,会在大脑中形成具有神经毒性的斑块。β-淀粉样蛋白(20.1)单克隆抗体能识别在神经退行性疾病和代谢性疾病中起重要作用的蛋白质,淀粉样蛋白沉积与 II 型糖尿病和唐氏综合征有关。人体血小板中的β-淀粉样蛋白突显了其更广泛的生理和病理作用。APP 经过交替剪接产生多种异构体,增加了功能和调节的复杂性。4 kDa β-淀粉样肽的形成有助于阿尔茨海默病中神经纤维缠结和老年斑的形成。与 APLP1 和 APLP2 等结构相似的蛋白质之间的相互作用显示了影响淀粉样蛋白相关病症的复杂蛋白质网络。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

β-Amyloid 抗体 (20.1) 参考文献:

  1. β-淀粉样蛋白肽的膜紊乱效应。  |  Müller, WE., et al. 2001. Biochem Soc Trans. 29: 617-23. PMID: 11498039
  2. β淀粉样蛋白的多价和多功能配体。  |  Kim, Y., et al. 2009. Curr Pharm Des. 15: 637-58. PMID: 19199987
  3. β-淀粉样蛋白肽在神经退行性疾病中的作用。  |  Maltsev, AV., et al. 2011. Ageing Res Rev. 10: 440-52. PMID: 21406255
  4. β-淀粉样蛋白与胆碱能神经传递之间的危险联系。  |  Govoni, S., et al. 2014. Curr Pharm Des. 20: 2525-38. PMID: 23859550
  5. 清除大脑中的β淀粉样蛋白。  |  Ueno, M., et al. 2014. Curr Med Chem. 21: 4085-90. PMID: 25312211
  6. β-片层干扰分子可抑制β-淀粉样蛋白聚集和纤维化。  |  Francioso, A., et al. 2015. Bioorg Med Chem. 23: 1671-83. PMID: 25769517
  7. Tau、β淀粉样蛋白和α-Synuclein病理之间的关系。  |  Walker, L. and Attems, J. 2019. Adv Exp Med Biol. 1184: 169-176. PMID: 32096037
  8. 枕叶脑血管反应性受损是血管β-淀粉样蛋白的生物标志物。  |  Schreiber, S. and DiFrancesco, JC. 2020. Neurology. 95: 415-416. PMID: 32641536
  9. NLRP3与感染:炎症小体中的β-淀粉样蛋白与神经退行性疾病。  |  Sita, G., et al. 2021. Int J Mol Sci. 22: PMID: 34209586
  10. 调节β淀粉样肽聚集的纳米材料。  |  Huang, Y., et al. 2021. Molecules. 26: PMID: 34299575

订购信息

产品名称产品编号规格价格数量收藏夹

β-Amyloid 抗体 (20.1)

sc-53822
200 µg/ml
CNY2422.00

β-Amyloid (20.1): m-IgG Fc BP-HRP 套装

sc-525618
200 µg Ab; 10 µg BP
CNY2715.00

β-Amyloid 抗体 (20.1) AC

sc-53822 AC
500 µg/ml, 25% agarose
CNY3189.00

β-Amyloid 抗体 (20.1) HRP

sc-53822 HRP
200 µg/ml
CNY2422.00

β-Amyloid 抗体 (20.1) FITC

sc-53822 FITC
200 µg/ml
CNY2527.00

β-Amyloid 抗体 (20.1) PE

sc-53822 PE
200 µg/ml
CNY2625.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 488

sc-53822 AF488
200 µg/ml
CNY2738.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 546

sc-53822 AF546
200 µg/ml
CNY2738.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 594

sc-53822 AF594
200 µg/ml
CNY2738.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 647

sc-53822 AF647
200 µg/ml
CNY2738.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 680

sc-53822 AF680
200 µg/ml
CNY2738.00

β-Amyloid 抗体 (20.1) Alexa Fluor® 790

sc-53822 AF790
200 µg/ml
CNY2738.00

Can this antibody detect both AB40 and 42?

Asked by: H Park
Thank you for your question. Unfortunately, this antibody doesn't recommend to detect either Abeta42 or Abeta40. Please contact us via email [email protected] or live chat on the website if you have addtional questions.
Answered by: Technical Service SH
Date published: 2024-11-14

I am using β-Amyloid (20.1): sc-53822 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: AbPolly
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by jenniferc from Positive resultsWas able to detect desired band with this antibody
Date published: 2017-01-19
Rated 5 out of 5 by SF from Produced beautiful immunoperoxidase cytoplasmicProduced beautiful immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human brain tissue. -SCBT QC
Date published: 2015-05-19
Rated 5 out of 5 by LM from Published mass spectra dataPublished mass spectra data. -SCBT Publication Review
Date published: 2015-05-12
Rated 4 out of 5 by LF from Positive results in western blot analysisPositive results in western blot analysis of Amyloid precursor protein expression in PC-3, U-87 MG and H4 whole cell lysates and rat brain and human brain tissue extracts -SCBT QC
Date published: 2015-04-29
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β-Amyloid 抗体 (20.1) is rated 4.8 out of 5 by 4.
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