Berninamycin A CAS: 58798-97-3
MF: C51H51N15O15S
MW: 1146.1
An antibiotic that contains sulfur and highly modified cyclic peptides.

Berninamycin A (CAS 58798-97-3)

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Alternate Names: Berninamycin, Antibiotic U27810
Application: Berninamycin A is an antibiotic that contains sulfur and highly modified cyclic peptides
CAS Number: 58798-97-3
Purity: >99%
Molecular Weight: 1146.1
Molecular Formula: C51H51N15O15S
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).
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Berninamycin A is a member of the thiopeptide antibiotic family, which is described to contain sulfur and highly modified cyclic peptides. The compound has been reported to induce the tipA gene, which produces the proteins TipAL and TipsAS, that belong to the MerR family of transcription regulators. Studies indicate that Berninamycin A is a major component of Berninamycin. Berninamycin is described to affect the function of the ribosomal A site, act as a vigorous inhibitor of protein synthesis in gram-positive bacteria, and has the same mode of action as Thiostrepton (sc-2034120). Studies report that Berninamycin A is isolated from Streptomyces and is structurally related to sulfomycin I. Other Berninamycins include Berninamycin B, C, and D (sc-202078).


参考文献

1. Reusser, F. 1969. Biochemistry. 8: 3303-3308. PMID: 4980191
2. Liesch, J.M., et al. 1976. J. Am. Chem. Soc. 98: 299-300. PMID: 1244374
3. Thompson, J., et al. 1982. J. Gen. Microbiol. 128: 875-884. PMID: 6181185
4. Abe, H., et al. 1987. Tetrahedron Letters. 29: 1401-1404
5. Lau, R.C. and Rinehart, K.L. 1994. J. Antibiot. 47: 1466-1472. PMID: 7844041
6. Chiu, M.L., et al. 1999. J. Biol. Chem. 274: 20578-20586. PMID: 10400688

Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in DMSO, DMF, water (poor), ethanol (moderately), and methanol (moderately).
Storage :
Store at -20° C
Density :
1.53 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
仅供科研使用。不可用于诊断或治疗。
PubChem CID :
16156770
MDL Number :
MFCD14635430
SMILES :
C/C=C\\1/C2=NC(=C(O2)C)C(=O)NC(=C)C(=O)NC(C(=O)NC(=C)C3=NC(=C(O3)C)C(=O)NC(=C)C(=O)NC(=C)C4=NC(=CO4)C5=C(C=CC(=N5)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C6=NC(=CS6)C(=O)NC(C(=O)N1)C(C)O)C(C)(C)O

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