Bentamapimod 是一种选择性 JNK(Jun 激酶)抑制剂,经口服发现具有活性。这种小分子可阻止 T 细胞增殖并诱导细胞凋亡。
Bentamapimod (CAS 848344-36-5) 参考文献
S Halazy. Designing heterocyclic selective kinase inhibitors: from concept to new drug candidates. ARKIVOC 2006 (vii) 496-508.
C Chiara Ferrandi et al. Characterization of immune cell subsets during the active phase of multiple sclerosis reveals disease and c-Jun N-terminal kinase pathway biomarkers. Mult. Scler. J. 2011, 17(1), 43-56.
SS Bhagwat. Chapter 17 MAP Kinase Inhibitors in Inflammation and Autoimmune Disorders. Ann. Rep. Med. Chem. 2007, 42, 265-278.
抑制剂:
JNK, 和 Ser/Thr Protein Kinase.
物理状态 :
Solid
溶解度 :
Soluble in DMSO (10.8 mg/ml), and 0.1N HCl (aq.) (44.4 mg/ml). Insoluble in water.