Date published: 2025-9-7

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Bcl-11a 抗体 (H-1): sc-514842

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说明书
  • Bcl-11a 抗体 H-1 是小鼠单克隆 IgG2a κ,Bcl-11a抗体, 在2篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列505-620位于human物种的Bcl-11a的内部区域内
  • Bcl-11a 抗体 (H-1) 推荐用于 WB, IP, IF 和 ELISA,检测mouse, rat 和human 来源的 Bcl-11a
  • 抗Bcl-11a抗体(H-1)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取Bcl-11a (H-1): sc-514842免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是Bcl-11a Antibody (H-1) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与Bcl-11a Antibody (H-1) 打包提供(请参阅下面的订购信息)。

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関連項目

Bcl-11a抗体(H-1)是一种小鼠单克隆IgG2a kappa轻链抗体,可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测小鼠、大鼠和人类来源的Bcl-11a蛋白。抗Bcl-11a抗体(H-1)有非结合型和多种结合型,包括琼脂糖、辣根过氧化物酶(HRP)、藻红蛋白(PE)、异硫氰酸荧光素(FITC)和多种Alexa Fluor®结合物。Bcl-11a蛋白,也称为CtIP-1或EVI9,在淋巴细胞生成中发挥着关键作用,而淋巴细胞是负责适应性免疫的免疫细胞。Bcl-11a的正常功能至关重要,因为Bcl-11b基因座紊乱会影响造血恶性肿瘤的进展,并导致T细胞急性淋巴细胞白血病。Bcl-11a蛋白在淋巴细胞发育过程中充当转录抑制剂并调节基因表达。值得注意的是,Bcl-11a与Bcl-6相互作用,后者是一种与多种淋巴恶性肿瘤相关的著名转录抑制剂,表明其在白血病发病机理中发挥作用。此外,Bcl-11a基因是骨髓性白血病中逆转录病毒整合的常见位点,这凸显了其作为治疗干预靶标的潜力。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bcl-11a 抗体 (H-1) 参考文献:

  1. B 细胞慢性淋巴细胞白血病中免疫球蛋白基因的配置。  |  Dyer, MJ. and Oscier, DG. 2002. Leukemia. 16: 973-84. PMID: 12040429
  2. COUP-TF(鸡卵清蛋白上游启动子转录因子)-互作蛋白 1(CTIP1)是一种序列特异性 DNA 结合蛋白。  |  Avram, D., et al. 2002. Biochem J. 368: 555-63. PMID: 12196208
  3. Bcl11a 对于淋巴细胞的正常发育至关重要。  |  Liu, P., et al. 2003. Nat Immunol. 4: 525-32. PMID: 12717432
  4. Bcl11:淋巴发育过程中的同胞竞争。  |  Durum, SK. 2003. Nat Immunol. 4: 512-4. PMID: 12774073
  5. 在小儿 T-ALL 细胞系中,心脏同源染色体基因 NKX2-5 通过与 BCL11B 并位而发生失调,其突变位点为 t(5;14)(q35.1;q32.2)。  |  Nagel, S., et al. 2003. Cancer Res. 63: 5329-34. PMID: 14500364
  6. 使用离心法和修饰组蛋白 H3 抗体分析染色质结构的两种不同方法:两种方法都能提供 Rit1/Bcl11b 基因的相似染色质状态。  |  Togashi, T., et al. 2004. Biochem Biophys Res Commun. 313: 489-95. PMID: 14697215
  7. V(D)J重组酶参与了伽马射线诱导的胸腺淋巴瘤和小鼠正常胸腺中Rit1/Bcl11b肿瘤抑制基因的基因内缺失的产生。  |  Sakata, J., et al. 2004. Carcinogenesis. 25: 1069-75. PMID: 14754877
  8. 在哺乳动物细胞中,SIRT1 依赖 BCL11A 招募到启动子模板,导致组蛋白去乙酰化和转录抑制。  |  Senawong, T., et al. 2005. Arch Biochem Biophys. 434: 316-25. PMID: 15639232
  9. 控制体内皮质脊髓运动神经元发育的神经元亚型特异基因  |  Arlotta, P., et al. 2005. Neuron. 45: 207-21. PMID: 15664173
  10. 通过 inv(14)(q11.2q32.31)中断 BCL11B 基因会导致 BCL11B-TRDC 融合转录本的表达,这与 T-ALL 中缺乏野生型 BCL11B 转录本有关。  |  Przybylski, GK., et al. 2005. Leukemia. 19: 201-8. PMID: 15668700
  11. p53 阻止 Bcl11b-/- 小鼠的 T 细胞发育成熟到 CD4-CD8+ 未成熟阶段。  |  Okazuka, K., et al. 2005. Biochem Biophys Res Commun. 328: 545-9. PMID: 15694382
  12. 权变基因调控网络与 B 细胞命运规范  |  Singh, H., et al. 2005. Proc Natl Acad Sci U S A. 102: 4949-53. PMID: 15788530
  13. BCL11B 在功能上与 T 淋巴细胞中的 NuRD 复合物结合,抑制目标启动子。  |  Cismasiu, VB., et al. 2005. Oncogene. 24: 6753-64. PMID: 16091750

订购信息

产品名称产品编号规格价格数量收藏夹

Bcl-11a 抗体 (H-1)

sc-514842
200 µg/ml
RMB2377.00

Bcl-11a (H-1): m-IgG Fc BP-HRP 套装

sc-526393
200 µg Ab; 10 µg BP
RMB2662.00

Bcl-11a (H-1): m-IgG2a BP-HRP 套装

sc-546620
200 µg Ab; 10 µg BP
RMB2662.00

Bcl-11a 抗体 (H-1) AC

sc-514842 AC
500 µg/ml, 25% agarose
RMB3129.00

Bcl-11a 抗体 (H-1) HRP

sc-514842 HRP
200 µg/ml
RMB2377.00

Bcl-11a 抗体 (H-1) FITC

sc-514842 FITC
200 µg/ml
RMB2482.00

Bcl-11a 抗体 (H-1) PE

sc-514842 PE
200 µg/ml
RMB2580.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 488

sc-514842 AF488
200 µg/ml
RMB2685.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 546

sc-514842 AF546
200 µg/ml
RMB2685.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 594

sc-514842 AF594
200 µg/ml
RMB2685.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 647

sc-514842 AF647
200 µg/ml
RMB2685.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 680

sc-514842 AF680
200 µg/ml
RMB2685.00

Bcl-11a 抗体 (H-1) Alexa Fluor® 790

sc-514842 AF790
200 µg/ml
RMB2685.00

Hello, We ordered BCL11A -HRP conjugated from your company but it never seems to work on its own. We always have to incubate it with a secondary anti-mouse to see any type of signal. This is very frustrating as there is a reason we ordered HRP conjugat

Asked by: Mset
Thank you for your question. We offer a 12-month warranty on all products you purchase from us. Please get in touch with our technical service team and we will be happy to help you out.
Answered by: Tech Support Europe
Date published: 2020-08-28

Are there any issues with using sc-514842: Bcl-11a (H-1) mouse monoclonal primary antibody on mouse samples?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. To eliminate any potential cross-reactivity of an anti-mouse secondary detection reagent,we recommend using a directly conjugated primary antibody. Please contact our special orders department for pricing and availability of sc-514842 conjugates.
Answered by: Technical Support
Date published: 2017-03-07
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Rated 4 out of 5 by from Worked for IP and WBIPed endogenous protein from HEK293T cells. Specific band at expected size.
Date published: 2018-01-14
Rated 2 out of 5 by from Beaucoup de bruit de fondBcl11a étant peu exprimé dans mon extrait protéique, je suis obligée d'exposer longuement mais ceci augmente considérablement mon bruit de fond.
Date published: 2017-12-11
Rated 5 out of 5 by from Works great in WBClean, strong band ~120kDa from erythroid cell culture samples
Date published: 2017-10-27
Rated 5 out of 5 by from Works in Embryonic Neural Tissue for IHCWas able to get working well in embryonic PFA fixed neural tissue 1:200 O/N with Antigen Retrieval
Date published: 2017-08-17
Rated 5 out of 5 by from good resultWe used it in our WB,I got a good result in melanoma cancer cells with this antibody.
Date published: 2017-05-09
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Bcl-11a 抗体 (H-1) is rated 4.2 out of 5 by 5.
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