Date published: 2025-9-7

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Bag-5 抗体 (18Z): sc-101215

5.0(3)
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说明书
  • Bag-5抗体(18Z)是小鼠单克隆IgG1 κ, 在1篇文献中引用,规格为100 µg/ml
  • 免疫human物种的重组Bag-5
  • 推荐用于 human 来源的Bag-5 WB, IP 和 ELISA检测
  • 目前,我们还没有完成Bag-5 抗体 (18Z)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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関連項目

Bag-5(Bcl-2相关athanogene 5),也称为Bag家族分子伴侣调节因子5,是Bag蛋白家族的成员,含有四个Bag结构域。通过其Bag结构域,Bag蛋白以高亲和力与HSC 70/HSP 70 ATPase结构域结合,调节伴侣活性和细胞凋亡。Bag-5是HSP 70/Parkin复合物的组成部分,起抑制Parkin E3泛素连接酶活性和HSP 70伴侣活性的作用。在这个复合物中,Bag-5直接与HSP 70的ATPase结构域和Parkin的N端连接区相互作用。Bag-5的表达在多巴胺能神经元损伤时被诱导,并使神经元对损伤诱导的细胞死亡敏感。此外,Bag-5可能是治疗由Parkin基因突变引起的帕金森病等神经退行性疾病的有效靶点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bag-5 抗体 (18Z) 参考文献:

  1. 三种新生儿复苏设备的比较。  |  Bennett, S., et al. 2005. Resuscitation. 67: 113-8. PMID: 16081202
  2. 护理干预以降低导管相关性尿路感染的风险:第2部分:员工教育、监测和护理技术。  |  Willson, M., et al. 2009. J Wound Ostomy Continence Nurs. 36: 137-54. PMID: 19287262
  3. CA125--改变心脏的测试。  |  Sikaris, KA. 2011. Heart Lung Circ. 20: 634-40. PMID: 20822954
  4. [BAG家族基因及其与肺腺癌易感性的关系]。  |  Li, Y., et al. 2010. Zhongguo Fei Ai Za Zhi. 13: 942-6. PMID: 20959066
  5. 用于骨科增强的可注射不透射线且具有生物活性的聚己内酯-陶瓷复合材料。  |  No, YJ., et al. 2015. J Biomed Mater Res B Appl Biomater. 103: 1465-77. PMID: 25449121
  6. 共轭蛋白BAG5的功能丧失突变会导致扩张型心肌病,需要心脏移植。  |  Hakui, H., et al. 2022. Sci Transl Med. 14: eabf3274. PMID: 35044787
  7. ALK重排肾细胞癌与TPM3::ALK基因融合和文献综述。  |  Galea, LA., et al. 2023. Virchows Arch. 482: 625-633. PMID: 36370168
  8. Akt通过Bag5从单泛素化到多泛素化的转换进行控制。  |  Bracho-Valdés, I., et al. 2023. Int J Mol Sci. 24: PMID: 38139359
  9. BAG5调节HSPA8介导的蛋白质折叠,这是精子头尾连接装置组装所必需的。  |  Gan, S., et al. 2024. EMBO Rep. 25: 2045-2070. PMID: 38454159
  10. 进化保守的 Hsp70/Hsc70 分子伴侣调节器家族。  |  Takayama, S., et al. 1999. J Biol Chem. 274: 781-6. PMID: 9873016

订购信息

产品名称产品编号规格价格数量收藏夹

Bag-5 抗体 (18Z)

sc-101215
100 µg/ml
$333.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with Bag-5 (18Z): sc-101215 antibody?

Asked by: Cweed
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from High QualityThe Bag-5 Antibody (18Z): sc-101215 provides excellent data for Western blot applications, showing strong band with minimal background noise present.
Date published: 2017-02-03
Rated 5 out of 5 by from Good specificity in WB in mouse transfectedGood specificity in WB in mouse transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-27
Rated 5 out of 5 by from Strong band in WB in Jurkat whole cell lysatesStrong band in WB in Jurkat whole cell lysates. -SCBT QC
Date published: 2014-02-23
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Bag-5 抗体 (18Z) is rated 5.0 out of 5 by 3.
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