Date published: 2025-9-8
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Bag-1 Antibody (CC9E8) - Western Blotting - Image 362112
Bag-1 抗体 (CC9E8): sc-33704. 在 HeLa (A), HL-60 (B), RAW 264. 7 (C), NIH/3T3 (D) 和 L6 (E) 全细胞裂解液中 Bag-1 表达的 Western 印迹分析.
Bag-1 抗体 (CC9E8): sc-33704. 在 HeLa (A), HL-60 (B), RAW 264. 7 (C), NIH/3T3 (D) 和 L6 (E) 全细胞裂解液中 Bag-1 表达的 Western 印迹分析.

Bag-1 抗体 (CC9E8): sc-33704

5.0(8)
寫評論提問

说明书
  • Bag-1抗体(CC9E8)是小鼠单克隆IgG1 κ, 在9篇文献中引用，规格为200 µg/ml
  • 针对与human Bag-1分子C-terminus的200个氨基酸区域相对应的重组蛋白
  • 推荐用于 mouse, rat 和 human 来源的Bag-1 WB, IP, IF 和 IHC(P)检测
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 Bag-1 抗体 (CC9E8) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与Bag-1 抗体 (CC9E8) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Bag 抗体 包括 Bag-1, Bag-2, Bag-3, Bag-5和BAG-6

Bcl-2蛋白家族的特点是在广泛的生理条件下能够调节细胞死亡（凋亡）。Bcl-2和几种相关蛋白的功能是抑制凋亡，而Bcl-2家族的其他成员，如Bax和Bak，则在不同条件下促进细胞死亡。例如，Bcl-xL抑制细胞死亡，而其较短的形式Bcl-xS则促进凋亡。该家族的另一个成员Bad与Bcl-xL的二聚化导致Bax从Bcl-xL/Bax复合物中位移并恢复Bax介导的凋亡。一种名为Bag-1的Bcl-2结合蛋白与Bcl-2或其他Bcl-2相关蛋白没有显著的同源性。Bag-1似乎能增强Bcl-2对细胞死亡的保护作用，这表明Bag-1代表了一种新型的抗细胞死亡基因。这也表明，以前归因于Bcl-2独立途径的某些凋亡诱导途径可能反而反映了Bcl-2和Bag-1组合的要求。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Bag-1 抗体 (CC9E8) 参考文献:

  1. BAG-1 与 p50-p50 同源 NF-κB 复合物相互作用：对结直肠癌发生的影响。  |  Southern, SL., et al. 2012. Oncogene. 31: 2761-72. PMID: 21963853
  2. BAG-1以泛素样结构域依赖的方式稳定突变型F508del-CFTR。  |  Mendes, F., et al. 2012. Cell Physiol Biochem. 30: 1120-33. PMID: 23178238
  3. 靶向 BAG-1：提高急性髓性白血病药物疗效的新策略。  |  Aveic, S., et al. 2015. Exp Hematol. 43: 180-190.e6. PMID: 25461257
  4. Bcl-2-associated athanogene-1 (BAG-1)对成骨细胞发育的调控。  |  Greenhough, J., et al. 2016. Sci Rep. 6: 33504. PMID: 27633857
  5. 通过影响 PI3K/Akt/mTOR 和 MAPK 信号通路，沉默 Bag-1 可增强化疗药物诱导的 MCF-7 乳腺癌细胞凋亡。  |  Kilbas, PO., et al. 2019. Mol Biol Rep. 46: 847-860. PMID: 30661182
  6. 抑制BAG-1诱导的SH-SY5Y细胞凋亡而不影响Hsp70表达。  |  Song, YK., et al. 2020. J Cell Biochem. 121: 1728-1735. PMID: 31609014
  7. BAG-1沉默通过多种基因途径使非小细胞肺癌细胞对顺铂敏感。  |  Lv, J., et al. 2019. Onco Targets Ther. 12: 8977-8989. PMID: 31802907
  8. Bag-1 通过激活 Akt 和 Raf 激酶刺激 Bad 磷酸化，从而介导乳腺癌细胞的存活。  |  Kizilboga, T., et al. 2019. BMC Cancer. 19: 1254. PMID: 31883527
  9. BAG-1基因域的突变会降低其对缺氧/再氧化的保护作用，通过调节SY-SH5Y细胞中的HSP70和PI3K/AKT信号通路。  |  Chen, Y., et al. 2021. Brain Res. 1751: 147192. PMID: 33152339
  10. BAG-1同源物的交互作用分析揭示了内质网相关降解中的新型相互作用伴侣。  |  Can, ND., et al. 2021. PLoS One. 16: e0256640. PMID: 34428256

订购信息

产品名称产品编号规格价格数量收藏夹

Bag-1 抗体 (CC9E8)

sc-33704
200 µg/ml
RMB2377.00

Bag-1 (CC9E8): m-IgG Fc BP-HRP 套装

sc-536781
200 µg Ab; 10 µg BP
RMB2662.00

Bag-1 (CC9E8): m-IgGκ BP-HRP 套装

sc-533945
200 µg Ab; 40 µg BP
RMB2662.00

Bag-1 (CC9E8): m-IgG1 BP-HRP 套装

sc-544816
200 µg Ab; 20 µg BP
RMB2662.00

I am using Bag-1 (CC9E8): sc-33704 monoclonal antibody to stain paraffin embedded tissue. Do you recommend antigen retrieval when using this antibody?

Asked by: Randy McDonald
We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-02-24
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Rated 5 out of 5 by from Strong signal strength in WB in HLStrong signal strength in WB in HL-60 whole cell lysate. -SCBT QC
Date published: 2015-07-13
Rated 5 out of 5 by from Good publishable data in WB in human HEK293Good publishable data in WB in human HEK293 and HeLa cells. -SCBT Publication Review
Date published: 2015-06-24
Rated 5 out of 5 by from Positive signal in WB in HeLa whole cell lysatePositive signal in WB in HeLa whole cell lysate. -SCBT QC
Date published: 2015-05-26
Rated 5 out of 5 by from Robust signal in WB in HeLaRobust signal in WB in HeLa, LNCaP, MCF7, SK-BR-3, Jurkat and HL-60 whole cell lysates. -SCBT QC
Date published: 2015-05-20
Rated 5 out of 5 by from Great immunoperoxidase cytoplasmic and nuclearGreat immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human breast tissue. -SCBT QC
Date published: 2015-05-18
Rated 5 out of 5 by from I have since been able to try out the BagI have since been able to try out the Bag-1 (CC9E8) antibody and it is working similarly to previous applications with a siRNA knock down of Bag1 in HeLa cells.
Date published: 2015-03-26
Rated 5 out of 5 by from Good specificity in WB in human transfectedGood specificity in WB in human transfected 293T whole cell lysates. -SCBT QC
Date published: 2015-03-20
Rated 5 out of 5 by from Strong band in WB in human Breast CancerStrong band in WB in human Breast Cancer cell lines. -SCBT Publication Review
Date published: 2015-01-17
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Bag-1 抗体 (CC9E8) is rated 5.0 out of 5 by 8.
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