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Atm 抗体 (ATM 11G12): sc-53173

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说明书
  • Atm抗体(ATM 11G12)是小鼠单克隆IgG1 κ, 在9篇文献中引用,规格为200 µg/ml
  • 免疫human物种的Atm的氨基酸992-1144
  • 推荐用于 human 来源的Atm WB, IP 和 IF检测
  • 看 Atm (G-12): sc-377293,可查看有标记的 Atm 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是Atm Antibody (ATM 11G12) for WB applications. 的首选辅助检测试剂,这些试剂现与Atm Antibody (ATM 11G12) 打包提供(请参阅下面的订购信息)。
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関連項目

Atm抗体(ATM 11G12)是一种小鼠单克隆IgG1 kappa轻链抗体,专门用于检测共济失调毛细血管扩张突变(ATM)蛋白。ATM单克隆抗体(ATM 11G12)针对人类ATM蛋白的表位,即氨基酸992-1144,确保在蛋白质印迹(WB)、免疫沉淀(IP)和免疫荧光(IF)应用中具有可靠的性能。ATM蛋白是磷脂酰肌醇3激酶相关激酶(PIKK)家族的重要成员,其结构复杂,包括多个HEAT重复序列和一个中央激酶结构域。这种复杂的结构对于ATM在协调细胞对DNA双链断裂的反应、促进DNA修复、细胞周期控制和细胞凋亡以维持基因组稳定方面发挥的作用至关重要。了解ATM的结构至关重要,因为ATM与各种底物和调节蛋白相互作用的能力调节着细胞稳态和应激反应的关键信号通路。ATM基因的突变会导致常染色体隐性遗传病共济失调毛细血管扩张症,其特征是神经变性、免疫缺陷和癌症易感性增加,这凸显了ATM在正常细胞功能和疾病中的重要性。抗ATM抗体(ATM 11G12)是研究人员研究ATM分子机制的重要工具,可用于对表达、定位以及与其他蛋白的相互作用进行详细研究。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Atm 抗体 (ATM 11G12) 参考文献:

  1. 共济失调-毛细血管扩张突变(ATM)基因中错义变体的功能和计算评估:增加癌症风险的突变。  |  Mitui, M., et al. 2009. Hum Mutat. 30: 12-21. PMID: 18634022
  2. ATM激活机制。  |  Paull, TT. 2015. Annu Rev Biochem. 84: 711-38. PMID: 25580527
  3. ATM激酶:远不止是DNA损伤反应蛋白。  |  Guleria, A. and Chandna, S. 2016. DNA Repair (Amst). 39: 1-20. PMID: 26777338
  4. 缺氧时的 ATM 激活--原因与后果  |  Olcina, MM., et al. 2014. Mol Cell Oncol. 1: e29903. PMID: 27308313
  5. ATM依赖的染色质重塑和DNA氧化损伤反应通路。  |  Berger, ND., et al. 2017. Philos Trans R Soc Lond B Biol Sci. 372: PMID: 28847820
  6. 共济失调-毛细血管扩张突变对癌症中碳代谢的调节。  |  Dahl, ES. and Aird, KM. 2017. Front Oncol. 7: 291. PMID: 29238697
  7. ATM在自噬中的多方面作用:从非选择性自噬到选择性自噬。  |  Liang, N., et al. 2019. Cell Biochem Funct. 37: 177-184. PMID: 30847960
  8. ATM:主要特征、信号通路及其在DNA损伤反应、肿瘤抑制和癌症发展中的不同作用。  |  Phan, LM. and Rezaeian, AH. 2021. Genes (Basel). 12: PMID: 34070860
  9. ATM抑制剂的进展:机遇与挑战。  |  Du, S., et al. 2024. Eur J Med Chem. 277: 116781. PMID: 39173286
  10. ATM:从基因到功能。  |  Rotman, G. and Shiloh, Y. 1998. Hum Mol Genet. 7: 1555-63. PMID: 9735376

订购信息

产品名称产品编号规格价格数量收藏夹

Atm 抗体 (ATM 11G12)

sc-53173
200 µg/ml
$322.00

Atm (ATM 11G12): m-IgG Fc BP-HRP 套装

sc-538976
200 µg Ab; 10 µg BP
$361.00

Atm (ATM 11G12): m-IgG1 BP-HRP 套装

sc-541188
200 µg Ab; 20 µg BP
$361.00

What is the recommended starting dilution for Western blot for sc-53173: Atm (ATM 11G12) monoclonal antibody?

Asked by: Professor Griffin
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 4 out of 5 by ET from Published data for ChIP and WB in human SCCPublished data for ChIP and WB in human SCC-11 cells. -SCBT Publication Review
Date published: 2015-02-01
Rated 4 out of 5 by HF from Worked well in WB in untreatedWorked well in WB in untreated, UV treated, and UV and lambda protein phosphatase treated HeLa nuclear extracts. -SCBT QC
Date published: 2015-01-05
Rated 4 out of 5 by HC from Positive signal in WB in SKPositive signal in WB in SK-N-SH whole cell lysate. -SCBT QC
Date published: 2013-03-06
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Atm 抗体 (ATM 11G12) is rated 4.0 out of 5 by 3.
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