Date published: 2025-9-8

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Arc 抗体 (40): sc-136278

4.5(2)
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说明书
  • Arc 抗体 40 是小鼠单克隆 IgG1,提供 50 µg/0.5 ml
  • 免疫rat物种的Arc的氨基酸264-385
  • 推荐用于 mouse, rat 和 human 来源的Arc WB 和 IP检测
  • 看 Arc (C-7): sc-17839,可查看有标记的 Arc 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • 目前,我们还没有完成Arc 抗体 (40)的首选二抗检测试剂的鉴定。这项工作正在进行中。

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    関連項目

    生长因子刺激已被证明可以诱导非神经元细胞中即刻早期基因的表达,这些基因编码的多种分子可能参与长期细胞反应。由神经递质刺激引起的类似反应也见于神经元细胞,有证据表明蛋白质合成是长期突触可塑性所必需的。Arc(用于活动调节的细胞骨架相关蛋白)是一种在大脑中富集的生长因子和即刻早期基因。Arc mRNA和蛋白质水平由神经元活动诱导,这对于刺激神经可塑性是必要的,表明Arc在活动依赖性树突功能变化中的潜在作用。已在海马、杏仁核、下丘脑、纹状体和皮层的神经元胞体和树突中检测到Arc表达。已显示Arc定位于神经元细胞的细胞骨架,并且似乎与F-肌动蛋白共定位,尽管它可能与肌动蛋白相关蛋白相关联而不是直接与F-肌动蛋白相关联。已显示可卡因刺激的神经元活动导致纹状体中Arc mRNA水平增加。因此,Arc在神经元活动调节和长期突触可塑性中发挥着重要作用,可能与多种神经精神疾病的发生和发展有关。对Arc的深入研究有助于进一步了解神经系统的正常功能和疾病状态下的异常变化,为开发新的治疗策略提供思路。

    仅限研究使用。不适用于诊断和治疗用途。

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Arc 抗体 (40)

    sc-136278
    50 µg/0.5 ml
    RMB2377.00

    What is the difference between the different Arc antibodies that Santa Cruz sells? (40, A-7, C-7, E-7)?

    Asked by: Alex1234
    Thank you for your question. These are all different clones of monoclonal antibodies that all have the same target protein, in this case Arc. Please contact Technical Service if you have any further questions.
    Answered by: Tech Service
    Date published: 2019-01-14

    I am using Arc (40): sc-136278 antibody for immunoprecipitation, how much antibody should I use?

    Asked by: AbPolly
    Thank you for your question. We recommend using 1–10 µl (i.e., 0.2–2 µg) of antibody with 1 ml of cell lysate. However, optimal antibody concentration should be determined by titration. Please find our full immunoprecipitation protocol here: https://www.scbt.com/scbt/resources/protocols/immunoprecipitation-western-blots
    Answered by: Technical Support
    Date published: 2017-03-24
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    Rated 5 out of 5 by from Good specificity shown by using transfectedGood specificity shown by using transfected and non-transfected 293T cells for over-expression of the human Arc protein via Western Blot analysis. -SCBT QC
    Date published: 2015-03-29
    Rated 4 out of 5 by from Positive detection of the Arc protein byPositive detection of the Arc protein by WB using rat cerebrum tissue extract. -SCBT QC
    Date published: 2014-02-25
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    Arc 抗体 (40) is rated 4.5 out of 5 by 2.
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