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APRIL 抗体 (H-10): sc-374674

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说明书
  • APRIL抗体(H-10)是小鼠单克隆IgG2a κ, 在1篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列105-164位于human物种的APRIL的内部区域内
  • 推荐用于 human 来源的mature APRIL WB, IP, IF 和 ELISA检测
  • m-IgG Fc BP-HRP2a BP-HRP">m-IgG2a BP-HRP是APRIL Antibody (H-10) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与APRIL Antibody (H-10) 打包提供(请参阅下面的订购信息)。

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関連項目

增殖诱导配体(APRIL),也被称为TNFSF13,是一种II型膜蛋白,它与肿瘤坏死因子(TNF)细胞因子家族的其他成员具有共同特征。APRIL在转化细胞系以及人类结肠、甲状腺和淋巴肿瘤组织中高水平表达。APRIL在感染、炎症、自身免疫性疾病和组织稳态的调节中起关键作用。APRIL涉及肿瘤细胞生长的调节。C端细胞外结构域具有果冻卷状拓扑结构,对于配体三聚化很重要。配体与其相应受体的结合可诱导寡聚化,从而启动下游信号事件。寡聚化的本质是在相邻亚基之间的连接处形成受体结合位点,从而创建一个多价配体。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

APRIL 抗体 (H-10) 参考文献:

  1. 星形胶质细胞表达促增殖配体(APRIL),其水平在多发性硬化症中升高。  |  Thangarajh, M., et al. 2007. Scand J Immunol. 65: 92-8. PMID: 17212772
  2. 促增殖配体(APRIL)的血清浓度在脓毒症中升高,并预测危重患者的死亡率。  |  Roderburg, C., et al. 2013. J Crit Care. 28: 882.e1-11. PMID: 23337484
  3. 促增殖配体(APRIL)在类风湿性关节炎发病机理中的作用。  |  Zhao, J., et al. 2014. Scand J Rheumatol. 43: 462-9. PMID: 24898359
  4. B细胞激活因子(BAFF)和促增殖配体(APRIL)介导记忆性CD4 T细胞的CD40非依赖性帮助。  |  Gorbacheva, V., et al. 2015. Am J Transplant. 15: 346-57. PMID: 25496308
  5. 促增殖配体(APRIL)在小鼠IgA肾病中的致病作用。  |  Kim, YG., et al. 2015. PLoS One. 10: e0137044. PMID: 26348210
  6. 尿B细胞激活因子(BAFF)和促增殖配体(APRIL):活动性狼疮肾炎的潜在生物标志物。  |  Phatak, S., et al. 2017. Clin Exp Immunol. 187: 376-382. PMID: 27804111
  7. 大量产生促增殖配体(APRIL)的巨噬细胞会导致免疫球蛋白G4相关疾病中的浆细胞积聚。  |  Kawakami, T., et al. 2019. Nephrol Dial Transplant. 34: 960-969. PMID: 30325430
  8. APRIL和BAFF在区分玻璃体视网膜淋巴瘤和葡萄膜炎方面发挥着关键作用。  |  Tian, S., et al. 2022. Clin Chim Acta. 535: 1-6. PMID: 35820532
  9. 妊娠早期血清中BAFF(B细胞激活因子)和APRIL(一种促增殖配体)的水平可能预示未来妊娠糖尿病的发生。  |  Banerjeee, S., et al. 2024. Diabetes Metab Syndr. 18: 103019. PMID: 38653036
  10. 小鼠BCMA、TACI、BAFF、APRIL和IL-6在支持不同组织中产生抗体的细胞方面具有独特且冗余的作用。  |  Eslami, M., et al. 2024. Proc Natl Acad Sci U S A. 121: e2404309121. PMID: 38990948

订购信息

产品名称产品编号规格价格数量收藏夹

APRIL 抗体 (H-10)

sc-374674
200 µg/ml
RMB2377.00

APRIL (H-10): m-IgG Fc BP-HRP 套装

sc-540493
200 µg Ab; 10 µg BP
RMB2662.00

APRIL (H-10): m-IgG2a BP-HRP 套装

sc-546916
200 µg Ab; 10 µg BP
RMB2662.00

What is the recommended starting dilution for Western blot for APRIL (H-10): sc-374674 monoclonal antibody?

Asked by: Trav11
Thank you for your question. The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, can be found in the “datasheet” link at the top of the product page, for which I have provided the link: https://datasheets.scbt.com/sc-374674.pdf If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Technical Support
Date published: 2017-03-01
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Rated 5 out of 5 by from Produced positive Western blot data of APRILProduced positive Western blot data of APRIL expression in non-transfected and human APRIL transfected TNFSF12 whole cell lysates. -SCBT QC
Date published: 2013-08-31
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APRIL 抗体 (H-10) is rated 5.0 out of 5 by 1.
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