Date published: 2025-9-9

021-6093-6350

SCBT Portrait Logo
Seach Input

Amphiphysin II 抗体 (G-10): sc-74487

5.0(3)
寫評論提問

说明书
  • Amphiphysin II抗体(G-10)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 针对氨基酸421-520的图谱,在Amphiphysin II的内部区域,human起源
  • 推荐用于 mouse, rat 和 human 来源的all Amphiphysin II isoforms WB, IP, IF, IHC(P) 和 ELISA检测
  • 看 Amphiphysin II (2F11): sc-23918,可查看有标记的 Amphiphysin II 抗体,包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP 是 Amphiphysin II 抗体 (G-10) 在 WB and IHC(P) 应用中的首选二抗检测试剂。该试剂现与Amphiphysin II 抗体 (G-10) 组合成套装提供。 (请参阅下面的订购信息)。

    快捷链接

    関連項目

    双亲蛋白是一种富含脑的蛋白质,具有N端脂质相互作用,并作为二聚体发挥作用。双亲蛋白包含膜弯曲BAR结构域、中间网格蛋白和接头结合结构域以及C端SH3结构域。在脑中,双亲蛋白I和II形成异二聚体,通过其SH3结构域与网格蛋白相关GTP酶Dynamin结合。这种结合对于神经元中的突触小泡再循环至关重要,因为它发生在Dynamin与网格蛋白包被的凹坑结合以及随后的囊泡出芽之前。在其他组织中,双亲蛋白可能在其他膜弯曲和曲率稳定事件中发挥关键作用。哺乳动物双亲蛋白、双亲蛋白I和双亲蛋白II具有相似的整体结构。双亲蛋白II的一种普遍存在的剪接形式不含网格蛋白或接头相互作用,在肌肉组织中高度表达,并参与T管网络的形成和稳定。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    Amphiphysin II 抗体 (G-10) 参考文献:

    1. 桥接整合器1(BIN1)基因型对年轻健康个体工作记忆、海马体积和功能连接的影响。  |  Zhang, X., et al. 2015. Neuropsychopharmacology. 40: 1794-803. PMID: 25630570
    2. 慢性粒细胞白血病中桥接整合子1和BCR-ABL1的逆向调节。  |  Trino, S., et al. 2016. Tumour Biol. 37: 217-25. PMID: 26194865
    3. BIN1调节动态T管膜。  |  Fu, Y. and Hong, T. 2016. Biochim Biophys Acta. 1863: 1839-47. PMID: 26578114
    4. 心肌梗死后 T 型微管形成扩大的分支结构,Junctophilin-2 和桥接整合因子 1 (BIN-1) 出现失调  |  Pinali, C., et al. 2017. J Am Heart Assoc. 6: PMID: 28473402
    5. 双亲蛋白(BIN1)通过负调控动力蛋白2来促进肌肉的正常成熟。  |  Cowling, BS., et al. 2017. J Clin Invest. 127: 4477-4487. PMID: 29130937
    6. 在阿尔茨海默病中,桥接整合因子-1蛋白的缺失会促进突触tau的积累并干扰tau的释放。  |  Glennon, EB., et al. 2020. Brain Commun. 2: PMID: 32500121
    7. MTM1的过度表达可预防和逆转BIN1相关的中心核肌病。  |  Giraud, Q., et al. 2023. Brain. 146: 4158-4173. PMID: 37490306
    8. BIN1K358R抑制小鼠阿尔茨海默氏病模型中胶质细胞对斑块的反应。  |  Garcia-Agudo, LF., et al. 2024. Alzheimers Dement. 20: 2922-2942. PMID: 38460121
    9. 阿尔茨海默病风险基因BIN1可调节人类诱导的谷氨酸能神经元中与活动相关的基因表达。  |  Saha, O., et al. 2024. Mol Psychiatry. 29: 2634-2646. PMID: 38514804
    10. sTREM2 介导阿尔茨海默病中BIN1基因多态性与Tau病理之间的相关性。  |  Guo, F., et al. 2024. J Alzheimers Dis. 101: 693-704. PMID: 39240638

    订购信息

    产品名称产品编号规格价格数量收藏夹

    Amphiphysin II 抗体 (G-10)

    sc-74487
    200 µg/ml
    RMB2377.00

    Amphiphysin II (G-10): m-IgG Fc BP-HRP 套装

    sc-539528
    200 µg Ab; 10 µg BP
    RMB2662.00

    Can Amphiphysin II (G-10): sc-74487 monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

    Asked by: Professor Griffin
    Thank you for your question. Yes, Amphiphysin II (G-10): sc-74487 has been validated for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
    Answered by: Technical Support
    Date published: 2017-02-27
    • y_2025, m_9, d_9, h_6CST
    • bvseo_bulk, prod_bvqa, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasquestionsanswers, tq_1
    • loc_zh_CN, sid_74487, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getContent, 98ms
    • QUESTIONS, PRODUCT
    Rated 5 out of 5 by from Excellent immunoperoxidase cytoplasmic stainingExcellent immunoperoxidase cytoplasmic staining in formalin fixed, paraffin-embedded human skeletal muscle tissue. -SCBT QC
    Date published: 2015-05-16
    Rated 5 out of 5 by from Clean bands in western blot using truncatedClean bands in western blot using truncated human Amphiphysin II transfected 293T and HeLa whole cell lysates. -SCBT QC
    Date published: 2015-04-22
    Rated 5 out of 5 by from Positive results in western blot analysisPositive results in western blot analysis of Amphiphysin II expression in HeLa nuclear extract, Jurkat and SJRH30 whole cell lysates and rat skeletal muscle tissue extract. -SCBT QC
    Date published: 2015-01-07
    • y_2025, m_9, d_9, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_74487, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getReviews, 16ms
    • REVIEWS, PRODUCT
    Amphiphysin II 抗体 (G-10) is rated 5.0 out of 5 by 3.
    • y_2025, m_9, d_9, h_6
    • bvseo_bulk, prod_bvrr, vn_bulk_3.0.42
    • cp_1, bvpage1
    • co_hasreviews, tv_0, tr_3
    • loc_zh_CN, sid_74487, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
    • clientName_scbt
    • bvseo_sdk, java_sdk, bvseo-4.0.0
    • CLOUD, getAggregateRating, 115ms
    • REVIEWS, PRODUCT