Date published: 2026-9-22

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Amphiphysin II Antibody (99D) - Western Blotting - Image 356305
Amphiphysin II 抗体 (99D): sc-13575. C2C12 (A) 和 NIH/3T3 (B) 全细胞裂解液中 Amphiphysin II 表达的 Western 印迹分析.
Amphiphysin II 抗体 (99D): sc-13575. C2C12 (A) 和 NIH/3T3 (B) 全细胞裂解液中 Amphiphysin II 表达的 Western 印迹分析.

Amphiphysin II 抗体 (99D): sc-13575

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说明书
  • Amphiphysin II抗体(99D)是小鼠单克隆IgG2b κ, 在11篇文献中引用，规格为200 µg/ml
  • 培养自human来源的Amphiphysin II外显子13
  • 推荐用于 mouse, rat, human 和 avian 来源的Amphiphysin II splice variants 1-10 WB, IP, IF 和 IHC(P)检测
  • 2b BP-HRP">m-IgG2b BP-HRP和m-IgGκ BP-HRP是Amphiphysin II Antibody (99D) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与Amphiphysin II Antibody (99D) 打包提供（请参阅下面的订购信息）。
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関連項目

额外Amphiphysin抗体，包括Amphiphysin II

Amphiphysin II 抗体 (99D) 是一种小鼠单克隆 IgG2b kappa 轻链抗体，可通过蛋白质印迹 (WB)、免疫沉淀 (IP)、免疫荧光 (IF) 和免疫组织化学检测小鼠、大鼠、人类和鸟类中的 Amphiphysin II。 Anti-Amphiphysin II 抗体 (99D) 可提供非结合形式，用于多种实验。Amphiphysin II是一种富含大脑的蛋白质，在神经递质传递中起重要作用。Amphiphysin II (99D) 单克隆抗体识别一种以二聚体形式存在的蛋白质，该蛋白质具有膜弯曲BAR结构域、中央Clathrin和适配器结合结构域以及C-末端SH3结构域。通过SH3结构域介导的Amphiphysin II和GTP酶Dynamin之间的相互作用，通过促进Dynamin与Clathrin包被的凹坑结合，导致囊泡的芽生，从而实现神经元中的突触囊泡再循环。Amphiphysin II的剪接变异体缺乏与Clathrin或适配子的相互作用，主要在肌肉组织中表达，并在T管网络形成和稳定中发挥关键作用，表明其在细胞动力学中具有多种功能。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

Amphiphysin II 抗体 (99D) 参考文献:

  1. 桥接整合素1（BIN1）：形式、功能与阿尔茨海默病。  |  Tan, MS., et al. 2013. Trends Mol Med. 19: 594-603. PMID: 23871436
  2. 生理和疾病中的双亲蛋白-2（BIN1）。  |  Prokic, I., et al. 2014. J Mol Med (Berl). 92: 453-63. PMID: 24590001
  3. 桥接整合素1（BIN1）在阿尔茨海默病中的机制作用。  |  Gao, P., et al. 2021. Cell Mol Neurobiol. 41: 1431-1440. PMID: 32719966
  4. 在认知能力正常的老年人中，桥接整合子1（BIN1）rs744373多态性与tau-PET负荷之间缺乏关联。  |  Schaeverbeke, J., et al. 2022. Alzheimers Dement (N Y). 8: e12227. PMID: 35229019
  5. BIN1 是小胶质细胞促炎和神经变性相关激活的关键调节因子。  |  Sudwarts, A., et al. 2022. Mol Neurodegener. 17: 33. PMID: 35526014
  6. 桥接整合子 1 (BIN1, rs6733839) 和性别是血管健康预测记忆衰老轨迹的调节因子。  |  Heal, M., et al. 2022. J Alzheimers Dis. 89: 265-281. PMID: 35871342
  7. 桥接整合酶1片段通过增强小鼠的溶酶体介导的内吞作用，加速了tau聚合和传播。  |  Zhang, X., et al. 2024. PLoS Biol. 22: e3002470. PMID: 38206965
  8. 心脏和骨骼肌中的双亲蛋白-2（BIN1）的功能和缺陷。  |  Giraud, Q. and Laporte, J. 2024. Trends Mol Med. 30: 579-591. PMID: 38514365

订购信息

产品名称产品编号规格价格数量收藏夹

Amphiphysin II 抗体 (99D)

sc-13575
200 µg/ml
CNY2422.00

Amphiphysin II (99D): m-IgGκ BP-HRP 套装

sc-520630
200 µg Ab, 40 µg BP
CNY2715.00

Amphiphysin II (99D): m-IgG2b BP-HRP 套装

sc-548843
200 µg Ab; 10 µg BP
CNY2715.00

Can this Amphiphysin II (99D): sc-13575 monoclonal antibody be used in IF or IHC with mouse tissue or cells? Will there be non-specific staining?

Asked by: cjMara
Thank you for your inquiry. The use of mouse monoclonal antibodies with mouse samples is very common and typically poses no problem. We recommend following our recommended protocol, provided below, https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining Alternatively, consider using our alternative antibody, Amphiphysin II (2F11): sc-23918, which we do offer directly conjugated to HRP and a variety of fluorochromes, if you wish to omit using any secondary detection reagent and potential non-specific binding.
Answered by: Technical Support
Date published: 2017-01-30
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Rated 5 out of 5 by from Produced publishable WB data on humanStrong Amphiphysin II antibody with references in primary literature for WB in LNCaP cells
Date published: 2017-01-12
Rated 5 out of 5 by from Published western blot data using humanPublished western blot data using human, rat fibroblasts and mouse myoblasts. -SCBT Publication Review
Date published: 2015-05-04
Rated 5 out of 5 by from Clean results in western blot using truncatedClean results in western blot using truncated human Amphiphysin II transfected 293T and HeLa whole cell lysates. -SCBT QC
Date published: 2015-02-25
Rated 5 out of 5 by from WB: robust band in Sol8 extractWB: robust band in Sol8 extract. -SCBT QC
Date published: 2015-01-15
Rated 5 out of 5 by from Beautiful immunoperoxidase nuclear and cytoplasmicBeautiful immunoperoxidase nuclear and cytoplasmic staining in formalin-fixed, paraffin-embedded human lung tumor. -SCBT QC
Date published: 2013-04-13
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Amphiphysin II 抗体 (99D) is rated 5.0 out of 5 by 5.
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