Date published: 2025-9-7
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α E-catenin Antibody (G-11) - Western Blotting - Image 380897
α E-catenin 抗体 (G-11): sc-9988. MCF7 (A), MDA-MB-231 (B), MDA-MB-435S (C) 和 C6 (D) 全细胞裂解液以及小鼠大脑 (E) 和大鼠乳腺 (F) 组织提取物中 α E-catenin 表达的 Western 印迹分析.
α E-catenin 抗体 (G-11): sc-9988. MCF7 (A), MDA-MB-231 (B), MDA-MB-435S (C) 和 C6 (D) 全细胞裂解液以及小鼠大脑 (E) 和大鼠乳腺 (F) 组织提取物中 α E-catenin 表达的 Western 印迹分析.

α E-catenin 抗体 (G-11): sc-9988

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说明书
  • alpha E-catenin 抗体 G-11 是小鼠单克隆 IgG1 κ，α E-catenin抗体, 在38篇文献中引用，规格为200 µg/ml
  • 免疫human来源α E-catenin位于C-terminus 的610-906514660氨基酸
  • alpha E-catenin 抗体 (G-11) 推荐用于 WB, IP, IF 和 IHC(P)，检测mouse, rat 和human 来源的 α E-catenin; 也和以下物种反应，包括： 和 equine, canine and bovine
  • 抗alpha E-catenin抗体（G-11）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取α E-catenin (G-11): sc-9988的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRP 和 m-IgGκ BP-HRP 是 α E-catenin 抗体 (G-11) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与α E-catenin 抗体 (G-11) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
蛋白序列
说明书与实验方案
研究信息

関連項目

此外 Catenin 抗体 包括 α E-catenin, α T-catenin, β-catenin, δ-catenin和γ-catenin

α E-catenin 抗体（G-11）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和免疫组织化学检测小鼠、大鼠和人类的α E-catenin。α E-catenin 抗体 抗体（G-11）有非结合型和多种结合型，包括琼脂糖、辣根过氧化物酶（HRP）、藻红蛋白（PE）、异硫氰酸荧光素（FITC）和多种Alexa Fluor®结合物。α E-catenin，又称粘蛋白相关蛋白α1，通过与β或γ-catenin和肌动蛋白丝相互作用，将E-cadherin与细胞骨架连接起来，在细胞粘附中起着至关重要的作用。这种连接维持了粘附连接的完整性，而粘附连接对于组织结构和细胞通讯至关重要。α E-catenin在发育中的大脑皮质室管区神经上皮前体细胞中含量丰富，α E-catenin有助于调节细胞密度和发育中的刺猬信号通路。α E-catenin和vinculin之间的相互作用对于上皮组织中顶点连接复合物的组装尤为重要，这凸显了α E-catenin在维持细胞结构和功能方面的作用。这种粘附复合物的破坏会导致癌细胞从原发性肿瘤中脱离，从而可能促进癌细胞的侵袭和转移，因此α E-catenin成为癌症研究的重要焦点。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

α E-catenin 抗体 (G-11) 参考文献:

  1. αE-catenin基因（CTNNA1）是人类结肠癌细胞的侵袭抑制基因。  |  Vermeulen, SJ., et al. 1999. Oncogene. 18: 905-15. PMID: 10023666
  2. 人类 alphaE-catenin 基因 CTNNA1：突变分析和罕见的截短剪接变体。  |  Vanpoucke, G., et al. 2002. Biochim Biophys Acta. 1574: 262-8. PMID: 11997091
  3. IGF-I 诱导的人类结肠癌细胞迁移需要α-catenin，但侵袭不需要α-catenin。  |  André, F., et al. 2004. Oncogene. 23: 1177-86. PMID: 14961074
  4. 发育中大脑皮层中 alpha-E-catenin 和 alpha-N-catenin 的差异表达。  |  Stocker, AM. and Chenn, A. 2006. Brain Res. 1073-1074: 151-8. PMID: 16457793
  5. αE-catenin通过调节刺猬信号通路控制大脑皮层的大小。  |  Lien, WH., et al. 2006. Science. 311: 1609-12. PMID: 16543460
  6. α-E-catenin与dynamitin结合并调节dynactin介导的细胞内运输。  |  Lien, WH., et al. 2008. J Cell Biol. 183: 989-97. PMID: 19075109
  7. α(E)-catenin调节肾上皮细胞中BMP-7的表达和迁移。  |  Nichols, LA., et al. 2014. Am J Nephrol. 39: 409-17. PMID: 24818804
  8. α(E)-catenin的缺失会通过增加肾小管上皮细胞的凋亡来增强顺铂诱导的肾毒性。  |  Wang, X., et al. 2014. Toxicol Sci. 141: 254-62. PMID: 24973089
  9. α-E-Catenin (CTNNA1)抑制膀胱癌细胞的增殖、侵袭和EMT。  |  Chi, Q., et al. 2020. Cancer Manag Res. 12: 12747-12758. PMID: 33364826
  10. Alpha 1(E)-catenin是一种肌动蛋白结合和捆绑蛋白，可介导F-肌动蛋白附着到膜粘附复合体上。  |  Rimm, DL., et al. 1995. Proc Natl Acad Sci U S A. 92: 8813-7. PMID: 7568023
  11. 另一种人 alphaE-catenin cDNA 的分子克隆。  |  Linkels, M., et al. 1997. Biochem Biophys Res Commun. 237: 177-81. PMID: 9266853
  12. α-Catenin-vinculin相互作用具有组织上皮细胞顶端连接复合体的功能。  |  Watabe-Uchida, M., et al. 1998. J Cell Biol. 142: 847-57. PMID: 9700171

订购信息

产品名称产品编号规格价格数量收藏夹

α E-catenin 抗体 (G-11)

sc-9988
200 µg/ml
RMB2377.00

α E-catenin (G-11): m-IgG Fc BP-HRP 套装

sc-528247
200 µg Ab; 10 µg BP
RMB2662.00

α E-catenin (G-11): m-IgGκ BP-HRP 套装

sc-520576
200 µg Ab, 40 µg BP
RMB2662.00

α E-catenin (G-11): m-IgG1 BP-HRP 套装

sc-542837
200 µg Ab; 20 µg BP
RMB2662.00

α E-catenin 抗体 (G-11) AC

sc-9988 AC
500 µg/ml, 25% agarose
RMB3129.00

α E-catenin 抗体 (G-11) HRP

sc-9988 HRP
200 µg/ml
RMB2377.00

α E-catenin 抗体 (G-11) FITC

sc-9988 FITC
200 µg/ml
RMB2482.00

α E-catenin 抗体 (G-11) PE

sc-9988 PE
200 µg/ml
RMB2580.00

α E-catenin 抗体 (G-11) Alexa Fluor® 488

sc-9988 AF488
200 µg/ml
RMB2685.00

α E-catenin 抗体 (G-11) Alexa Fluor® 546

sc-9988 AF546
200 µg/ml
RMB2685.00

α E-catenin 抗体 (G-11) Alexa Fluor® 594

sc-9988 AF594
200 µg/ml
RMB2685.00

α E-catenin 抗体 (G-11) Alexa Fluor® 647

sc-9988 AF647
200 µg/ml
RMB2685.00

α E-catenin 抗体 (G-11) Alexa Fluor® 680

sc-9988 AF680
200 µg/ml
RMB2685.00

α E-catenin 抗体 (G-11) Alexa Fluor® 790

sc-9988 AF790
200 µg/ml
RMB2685.00

Is there a blocking peptide for this antibody?

Asked by: AbPolly
Thank you for your question. This α E-catenin (G-11): sc-9988 monoclonal antibody is raised against a recombinant protein and not a short peptide, so it is not possible to design a blocking peptide for it.
Answered by: Technical Support 7
Date published: 2017-02-03
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Rated 4 out of 5 by from greatThis worked very well on western blotting! Both overexpressing and wild type showed positive signal.
Date published: 2018-02-20
Rated 5 out of 5 by from Good for IFIn Hek293 cells, IF signal is specific! I would suggest this one.
Date published: 2017-11-29
Rated 5 out of 5 by from perfectSC-9988 to detect rat breast tissue. Highly specific results were diluted with 1/200 in WB. The ideal effect has been achieved.
Date published: 2017-10-20
Rated 5 out of 5 by from The product is good.We used α E-catenin Antibody for western blot and got a very nice band for the correct molecular weight.And background is clear, simple operation, low cost, short cycle, which has been widely applied.
Date published: 2017-10-09
Rated 5 out of 5 by from specific/sharp bands detectedThis antibody was tested on human aortic endothelial cells post various treatments. It gives specific band with no background.
Date published: 2017-09-14
Rated 5 out of 5 by from FantasicI bought the Fibronectine antibody (EP5). This is really good to stain. Fibronectine was showed clearly.
Date published: 2017-09-05
Rated 5 out of 5 by from Test for mouse testisDilute 1:1000 to test mouse testis and appear a specific band between 100kd to 150 kd
Date published: 2017-08-15
Rated 5 out of 5 by from For WB analyisisThe detected signal was stonger with decrease dilution ,but to the conceration 1;1000,the band still very clear and strong signal.
Date published: 2017-07-08
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α E-catenin 抗体 (G-11) is rated 4.9 out of 5 by 17.
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