Date published: 2025-9-8

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AKR1A1 抗体 (B-10): sc-374204

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说明书
  • AKR1A1抗体(B-10)是小鼠单克隆IgG1 (kappa轻链),规格为200 µg/ml
  • 特异性抗原位于human物种的AKR1A1的内部区域内的氨基酸205-231之间
  • 推荐用于 mouse, rat 和 human 来源的AKR1A1 WB, IP, IF, IHC(P) 和 ELISA检测; 也和以下物种反应,包括: canine
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是AKR1A1 Antibody (B-10) 适用于 WB 和 IHC(P) 应用。 的首选辅助检测试剂。这些试剂现与AKR1A1 Antibody (B-10) 打包提供(请参阅下面的订购信息)。

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    関連項目

    AKR1A1(醛酮还原酶家族1成员A1),也被称为ALR(醛还原酶)、DD3(二氢二醇脱氢酶3)或ALDR1(醇脱氢酶),是醛酮还原酶(AKR)蛋白质家族中广泛且大量表达的成员。AKR家族的成员是可溶性的NADPH依赖性氧化还原酶,在药物、致癌物和反应性醛的代谢中发挥着重要作用。AKR1A1以单体的形式存在,催化外源性和生物源性的醛和酮还原为相应的醇。特别地,AKR1A1对中链和芳香醛具有高效的催化作用。此外,AKR1A1还参与胆固醇和甘油三酯的生物合成途径,并在多环芳烃(PAHs)的激活中发挥作用。

    仅限研究使用。不适用于诊断和治疗用途。

    Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

    LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

    AKR1A1 抗体 (B-10) 参考文献:

    1. 患有唐氏综合征和未患有唐氏综合征的供体心脏中蒽环类还原酶表达的个体差异。  |  Quiñones-Lombraña, A., et al. 2014. Pharm Res. 31: 1644-55. PMID: 24562808
    2. 鉴定调节蛋白质S-亚硝基化的S-亚硝基-CoA还原酶。  |  Anand, P., et al. 2014. Proc Natl Acad Sci U S A. 111: 18572-7. PMID: 25512491
    3. 羰基还原酶作为药物固定亲和载体的靶标。  |  Andrýs, R., et al. 2015. Chem Biol Interact. 234: 169-77. PMID: 25595226
    4. 乳腺癌化疗药与人类多柔比星还原酶的药代动力学相互作用。  |  Hofman, J., et al. 2015. Biochem Pharmacol. 96: 168-78. PMID: 25986883
    5. 脂肪细胞截留并代谢化疗药物多柔比星  |  Sheng, X., et al. 2017. Mol Cancer Res. 15: 1704-1713. PMID: 29117945
    6. 二聚二氢二醇脱氢酶是一种高效的灵长类1,5-脱水-D-果糖还原酶。  |  Hara, A., et al. 2020. Biochem Biophys Res Commun. 526: 728-732. PMID: 32253031
    7. 饮食诱导的肥胖和瘦小小鼠餐后肝脏中蛋白质复合物的整体情况。  |  Kim, SQ., et al. 2022. Biochem Biophys Res Commun. 629: 40-46. PMID: 36099783
    8. 睾酮代谢中人类醛酮还原酶和微生物β-葡萄糖醛酸酶的相关性。  |  Basit, A., et al. 2023. Drug Metab Dispos. 51: 427-435. PMID: 36623880
    9. 人类肠道中醛酮还原酶和短链脱氢酶/还原酶同工酶的mRNA和蛋白质表达水平的定量分析。  |  Hirosawa, K., et al. 2023. Drug Metab Dispos. 51: 1569-1577. PMID: 37722844
    10. 人类接触柴油尾气可诱导CYP1A1表达和芳香烃受体活化,而抗氧化反应却未得到协调。  |  Friberg, M., et al. 2023. Part Fibre Toxicol. 20: 47. PMID: 38062420

    订购信息

    产品名称产品编号规格价格数量收藏夹

    AKR1A1 抗体 (B-10)

    sc-374204
    200 µg/ml
    RMB2377.00

    AKR1A1 (B-10): m-IgG Fc BP-HRP 套装

    sc-537934
    200 µg Ab; 10 µg BP
    RMB2662.00

    AKR1A1 (B-10): m-IgGκ BP-HRP 套装

    sc-535417
    200 µg Ab; 40 µg BP
    RMB2662.00

    AKR1A1 (B-10): m-IgG1 BP-HRP 套装

    sc-545456
    200 µg Ab; 20 µg BP
    RMB2662.00

    AKR1A1 (B-10) 中和勝肽

    sc-374204 P
    100 µg/0.5 ml
    RMB511.00

    What application is the blocking peptide sc-374204 P appropriate for?

    Asked by: Cweed
    Thank you for your question. The blocking peptide is intended for use as a negative control, by pre-adsorbing the mouse monoclonal antibody against the antigen. For full protocol details, please contact our Technical Services Department or view our online protocol here: https://www.scbt.com/scbt/resources/protocols/peptide-neutralization
    Answered by: Technical Support
    Date published: 2017-03-01
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    Rated 5 out of 5 by from Produced great immunoperoxidase cytoplasmicProduced great immunoperoxidase cytoplasmic and nuclear staining in formalin fixed, paraffin-embedded human thyroid tissue. -SCBT QC
    Date published: 2015-03-11
    Rated 5 out of 5 by from Nice Western Blot data of AKR1A1 expression in nonNice Western Blot data of AKR1A1 expression in non-transfected 293T, human AKR1A1 transfected 293T and Hep G2 whole cell lysates. -SCBT QC
    Date published: 2013-06-27
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    AKR1A1 抗体 (B-10) is rated 5.0 out of 5 by 2.
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