Date published: 2025-9-7

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ADRP 抗体 (B-6): sc-377429

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说明书
  • ADRP 抗体 B-6 是小鼠单克隆 IgG1 κ,ADRP抗体, 在20篇文献中引用,规格为200 µg/ml
  • 免疫原氨基酸序列321-400位于human物种的ADRP的C-terminus附近
  • ADRP 抗体 (B-6) 推荐用于WB, IP, IF, IHC(P) 和 ELISA,检测human 来源的 ADRP
  • 抗ADRP抗体(B-6)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取ADRP (B-6): sc-377429免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP, m-IgG1 BP-HRPm-IgGκ BP-HRP 是 ADRP 抗体 (B-6) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与ADRP 抗体 (B-6) 组合成套装提供。 (请参阅下面的订购信息)。

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関連項目

ADRP抗体(B-6)是一种IgG1 κ小鼠单克隆ADRP抗体(也被指定为脂肪分化相关蛋白抗体、ADFP抗体、Adipophilin抗体、ADRP抗体或PLIN2抗体),可通过WB、IP、IF、IHC(P)和ELISA方法检测来自人类的ADRP蛋白。ADRP抗体(B-6)既有非偶联的抗ADRP抗体形式,也有多种偶联形式的抗ADRP抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。甘露糖6-磷酸受体(MPRs)将溶酶体水解酶从高尔基体运送到内体,然后再运回。货物选择蛋白TIP47(也被称为胎盘蛋白17)是内体到反式高尔基体网络运输所必需的,并与阳离子依赖性和非阳离子依赖性的MPRs的细胞质结构域相互作用。Adipophilin(ADRP)是围脂滴蛋白家族的另一个成员,是一种与乳脂球表面膜物质相关的蛋白质。磷酸蛋白Perilipin位于脂肪细胞内脂质小滴的表面,通过包裹脂肪细胞中的脂质储存小滴来保护它们,直到它们被脂肪酶消化。作为脂解的关键调节因子,Perilipin水平的升高与肥胖有关。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ADRP 抗体 (B-6) 参考文献:

  1. 在腺病毒重组系统中,过脂素A对激素敏感脂肪酶和蛋白激酶A介导的脂肪分解的调节作用。  |  Souza, SC., et al. 2002. J Biol Chem. 277: 8267-72. PMID: 11751901
  2. ADRP 可刺激小鼠成纤维细胞的脂质积累和脂滴形成。  |  Imamura, M., et al. 2002. Am J Physiol Endocrinol Metab. 283: E775-83. PMID: 12217895
  3. 人体脂肪组织中的 Perilipin 表达随肥胖而升高。  |  Kern, PA., et al. 2004. J Clin Endocrinol Metab. 89: 1352-8. PMID: 15001633
  4. S3-12, Adipophilin 和 TIP47 在脂肪细胞中包装脂质。  |  Wolins, NE., et al. 2005. J Biol Chem. 280: 19146-55. PMID: 15731108
  5. ADRP/adipophilin 在储脂细胞衰退过程中通过蛋白酶体依赖途径降解。  |  Masuda, Y., et al. 2006. J Lipid Res. 47: 87-98. PMID: 16230742
  6. 激素刺激工程脂肪细胞脂肪分解过程中脂滴相关蛋白的动态:脂肪细胞分化相关蛋白/嗜脂素的稳定和脂滴结合。  |  Gross, DN., et al. 2006. Mol Endocrinol. 20: 459-66. PMID: 16239256
  7. 胰岛素和脂肪酸调节原代人类滋养细胞中脂肪滴缔合作用蛋白adipophilin的表达。  |  Elchalal, U., et al. 2005. Am J Obstet Gynecol. 193: 1716-23. PMID: 16260216
  8. 针对 RHO 中 adRP 突变的基因扩增。  |  Lewin, AS., et al. 2014. Cold Spring Harb Perspect Med. 4: a017400. PMID: 25037104
  9. 人类动脉粥样硬化病变中 ADRP 表达的增加与斑块的不稳定性有关。  |  Xu, B., et al. 2015. Int J Clin Exp Med. 8: 5414-21. PMID: 26131118
  10. ARF1激活将ADRP从脂滴中分离出来,从而促进HCV组装。  |  Zhang, N., et al. 2016. Biochem Biophys Res Commun. 475: 31-6. PMID: 27157138
  11. adRP-10相关IMPDH1错义突变Asp226Asn对细胞存活和噬菌体组装的影响  |  Keppeke, GD., et al. 2023. Front Cell Dev Biol. 11: 1234592. PMID: 37731818
  12. 脂肪细胞分化相关蛋白作为乳脂球膜的成分分泌到乳汁中。  |  Heid, HW., et al. 1996. Biochem J. 320 (Pt 3): 1025-30. PMID: 9003395

订购信息

产品名称产品编号规格价格数量收藏夹

ADRP 抗体 (B-6)

sc-377429
200 µg/ml
RMB2377.00

ADRP (B-6): m-IgG Fc BP-HRP 套装

sc-530026
200 µg Ab; 10 µg BP
RMB2662.00

ADRP (B-6): m-IgGκ BP-HRP 套装

sc-523327
200 µg Ab, 40 µg BP
RMB2662.00

ADRP (B-6): m-IgG1 BP-HRP 套装

sc-543825
200 µg Ab; 20 µg BP
RMB2662.00

ADRP 抗体 (B-6) AC

sc-377429 AC
500 µg/ml, 25% agarose
RMB3129.00

ADRP 抗体 (B-6) HRP

sc-377429 HRP
200 µg/ml
RMB2377.00

ADRP 抗体 (B-6) FITC

sc-377429 FITC
200 µg/ml
RMB2482.00

ADRP 抗体 (B-6) PE

sc-377429 PE
200 µg/ml
RMB2580.00

ADRP 抗体 (B-6) Alexa Fluor® 488

sc-377429 AF488
200 µg/ml
RMB2685.00

ADRP 抗体 (B-6) Alexa Fluor® 546

sc-377429 AF546
200 µg/ml
RMB2685.00

ADRP 抗体 (B-6) Alexa Fluor® 594

sc-377429 AF594
200 µg/ml
RMB2685.00

ADRP 抗体 (B-6) Alexa Fluor® 647

sc-377429 AF647
200 µg/ml
RMB2685.00

ADRP 抗体 (B-6) Alexa Fluor® 680

sc-377429 AF680
200 µg/ml
RMB2685.00

ADRP 抗体 (B-6) Alexa Fluor® 790

sc-377429 AF790
200 µg/ml
RMB2685.00

Is this ab work for mouse Adrp? 

Asked by: Froggy
Thank you for your question . sc-377429 is only recommended for human samples .
Answered by: BlakeJ
Date published: 2023-03-21

Ich suche Antikörper gegen Perilipin 2 (PLIN-2) and Perilipin 3 (PLIN-3). Beide gehören zu PAT family. ADRP Antikörper (B-6) scheint PLIN-2 zu sein. Is das Korrekt? Haben Sie ein Antikörper gegen PLIN-3?

Asked by: Anonymous
Vielen Dank für Ihre Anfrage. ADRP Antikörper (B-6): sc-377429 detektiert ADRP, das mit PLIN-2 synonym ist. Die Proteinaccession für PLIN-3 lautet O60664. Wir führen entsprechende Antikörper unter der alternativen Bezeichnung "TIP47". Eine Übersicht über diese Antikörper finden Sie unter diesem Link: https://www.scbt.com/de/browse/tip47-Antik%C3%B6rper/_/N-86yjk4. "I am looking for an antibody specific against Perilipin 2 (PLIN-2) and Perilipin 3 (PLIN-3). Both belong to the PAT family. ADRP antibody (B-6) corresponds to PLIN-2. Is there an antibody against PLIN-3?" Thank you for your question. ADRP is synonymous with PLIN-2 and PLIN-3 is synonymous with TIP47. You can find our TIP47 antibodies by following this link: https://www.scbt.com/browse/tip47-Antik%C3%B6rper/_/N-86yjk4?&_requestid=1576779.
Answered by: Tech Support Europe
Date published: 2019-11-15

Can this antibody be used to detect ADRP of mouse origin?

Asked by: AbPolly
Thank you for your question. Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support 14
Date published: 2023-12-15
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Rated 5 out of 5 by from Ottimo anticorpoHo usato questo anticorpo per un analisi WB sulle linee cellulari HCT15, HCT116 e LS513. Ho ottenuto un buon segnale!
Date published: 2025-01-08
Rated 5 out of 5 by from Good and clean signalGood signal in lipid droplets isolated from mouse livers
Date published: 2024-10-15
Rated 4 out of 5 by from Good antibodyThis antibody works very well on western blot analysis
Date published: 2021-05-06
Rated 4 out of 5 by from 染色性が良い目的とする陽性部位の染色性は強く、目的以外の成分には非反応がなくきれいな染色結果でした。抗体の希釈する場合の、倍率も高くコストパフォーマンスも高いと思いました。
Date published: 2020-08-02
Rated 1 out of 5 by from hum..It does not work in my western blot of human cancer cell line
Date published: 2017-08-09
Rated 2 out of 5 by from Mouse liverWe tested WB of mouse liver at 1:500. Signal/Background was not great
Date published: 2017-05-16
Rated 5 out of 5 by from Works wellWorks well in Western Blot, a strong signal, we strongly recommend use it.
Date published: 2017-05-13
Rated 5 out of 5 by from The evaluation of ADRP Antibody (B-6)Firstly, thank you for providing this product. I have applyed this product in the WB of liver tissue of large yellow croaker, but it seems that this product can not used in large yellow croaker ,because I can not get the band even when the band of the internal reference GAPDH is perfect.
Date published: 2017-04-23
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ADRP 抗体 (B-6) is rated 4.3 out of 5 by 12.
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