Date published: 2025-9-6
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acetylated alpha Tubulin Antibody (6-11B-1) - Western Blotting - Image 391510
乙酰化 α 管蛋白抗体 (6-11B-1) Alexa Fluor® 647: sc-23950 AF647. 直接荧光西部印迹分析 Jurkat (A) 和 HeLa (B) 全细胞裂解液中乙酰化 α 管蛋白的表达. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 用 Cruz Marker MW Tag-Alexa Fluor® 488 检测 Cruz Marker™ 分子量标准: sc-516790.
乙酰化 α 管蛋白抗体 (6-11B-1) Alexa Fluor® 647: sc-23950 AF647. 直接荧光西部印迹分析 Jurkat (A) 和 HeLa (B) 全细胞裂解液中乙酰化 α 管蛋白的表达. 用 UltraCruz® 阻断试剂: sc-516214 阻断. 用 Cruz Marker MW Tag-Alexa Fluor® 488 检测 Cruz Marker™ 分子量标准: sc-516790.

acetylated alpha Tubulin 抗体 (6-11B-1): sc-23950

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寫評論提問

说明书
  • acetylated alpha Tubulin 抗体 6-11B-1 是小鼠单克隆 IgG2b κ，acetylated alpha Tubulin抗体, 在348篇文献中引用，规格为200 µg/ml
  • 针对紫海胆（Strongylocentrotus purpuratus）精子轴丝的外臂
  • acetylated alpha Tubulin 抗体 (6-11B-1) 推荐用于 WB, IP, IF 和 IHC(P)，检测mammalian species, zebrafish, Drosophila 和Xenopus 来源的 acetylated α Tubulin; 不会与 non-acetylated α Tubulin or other lysine acetylation sites产生交联反应
  • 抗acetylated alpha Tubulin抗体（6-11B-1）可与琼脂糖结合用于IP；与HRP结合用于WB、IHC(P)和ELISA；与藻红蛋白或FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 和 Alexa Fluor® 647，用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统，例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680 和 Alexa Fluor® 790， 用于WB (NIR), IF 和 FCM; 以及用于近红外（NIR）检测系统，如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取acetylated alpha Tubulin (6-11B-1): sc-23950的免费10 µg小样，联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP 和 m-IgG2b BP-HRP 是 acetylated alpha Tubulin 抗体 (6-11B-1) 在 WB and IHC(P) 应用中的首选二抗检测试剂。这些试剂现与acetylated alpha Tubulin 抗体 (6-11B-1) 组合成套装提供。 (请参阅下面的订购信息)。

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描述
基因信息
说明书与实验方案
研究信息

関連項目

此外 Tubulin 抗体 包括 α 1 Tubulin, α 3 Tubulin, α 4 Tubulin, α Tubulin, β Tubulin, β 2 Tubulin, β 3 Tubulin, δ Tubulin, ε Tubulin和γ Tubulin

乙酰化α微管蛋白抗体（6-11B-1）是一种小鼠单克隆IgG2b kappa轻链抗体，针对Strongylocentrotus purpuratus（海胆）精子轴丝的外臂，可特异性识别哺乳动物、斑马鱼、果蝇和非洲爪蟾中的乙酰化α微管蛋白。α-微管蛋白与β-微管蛋白结合形成异二聚体，聚合形成微管，这是细胞骨架的重要组成部分，负责维持细胞形状、促进细胞内运输和细胞分裂。α微管蛋白赖氨酸40位的乙酰化是一种关键的翻译后修饰，可增强微管的稳定性，影响与运动蛋白的相互作用，从而影响细胞内运输、纤毛和鞭毛运动以及细胞信号通路等过程。了解乙酰化α微管蛋白的功能和调节对于理解神经退行性疾病、癌症和发育生物学具有重要意义。抗乙酰化α微管蛋白抗体（6-11B-1）适用于蛋白质印迹（WB）、免疫沉淀（IP）、免疫荧光（IF）和石蜡包埋切片免疫组织化学（IHCP）等应用，为研究人员在各种生物系统中研究微管动力学和细胞骨架组织提供了宝贵的工具。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

acetylated alpha Tubulin 抗体 (6-11B-1) 参考文献:

  1. 乙酰化微管蛋白的定量。  |  Chesta, ME., et al. 2013. Cytoskeleton (Hoboken). 70: 297-303. PMID: 23596183
  2. 精子活力差的人体内乙酰化α-微管蛋白减少。  |  Bhagwat, S., et al. 2014. Fertil Steril. 101: 95-104.e3. PMID: 24268707
  3. 微管蛋白乙酰化：责任酶、生物功能和人类疾病。  |  Li, L. and Yang, XJ. 2015. Cell Mol Life Sci. 72: 4237-55. PMID: 26227334
  4. 乙酰化微管蛋白对小鼠的触觉至关重要。  |  Morley, SJ., et al. 2016. Elife. 5: PMID: 27976998
  5. 小鼠受精和早期发育过程中微管蛋白中的乙酰化α-微管蛋白。  |  Schatten, G., et al. 1988. Dev Biol. 130: 74-86. PMID: 3053299
  6. 乙酰化的α-微管蛋白K394调节微管的稳定性，从而影响轴突末梢的生长。  |  Saunders, HAJ., et al. 2022. Curr Biol. 32: 614-630.e5. PMID: 35081332
  7. 乙酰化α-微管蛋白减轻小鼠缺血性中风后对树突棘的损伤。  |  Yang, C., et al. 2023. CNS Neurosci Ther. 29: 2327-2338. PMID: 36965035
  8. SPAST遗传性痉挛性截瘫患者PBMC中乙酰化α-微管蛋白减少。  |  Wali, G., et al. 2023. Front Neurosci. 17: 1073516. PMID: 37144097
  9. 中心体扩增微调微管蛋白乙酰化，以不同方式控制细胞内组织。  |  Monteiro, P., et al. 2023. EMBO J. 42: e112812. PMID: 37403793
  10. 乙酰化α-微管蛋白和α-突触核蛋白：生理相互作用及其对α-突触核蛋白寡聚化的贡献。  |  Calogero, AM., et al. 2023. Int J Mol Sci. 24: PMID: 37569662

订购信息

产品名称产品编号规格价格数量收藏夹

acetylated alpha Tubulin 抗体 (6-11B-1)

sc-23950
200 µg/ml
RMB2377.00

acetylated alpha Tubulin (6-11B-1): m-IgG Fc BP-HRP 套装

sc-525509
200 µg Ab; 10 µg BP
RMB2662.00

acetylated alpha Tubulin (6-11B-1): m-IgG2b BP-HRP 套装

sc-549568
200 µg Ab; 10 µg BP
RMB2662.00

acetylated alpha Tubulin 抗体 (6-11B-1) AC

sc-23950 AC
500 µg/ml, 25% agarose
RMB3129.00

acetylated alpha Tubulin 抗体 (6-11B-1) HRP

sc-23950 HRP
200 µg/ml
RMB2377.00

acetylated alpha Tubulin 抗体 (6-11B-1) FITC

sc-23950 FITC
200 µg/ml
RMB2482.00

acetylated alpha Tubulin 抗体 (6-11B-1) PE

sc-23950 PE
200 µg/ml
RMB2580.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 488

sc-23950 AF488
200 µg/ml
RMB2685.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 546

sc-23950 AF546
200 µg/ml
RMB2685.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 594

sc-23950 AF594
200 µg/ml
RMB2685.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 647

sc-23950 AF647
200 µg/ml
RMB2685.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 680

sc-23950 AF680
200 µg/ml
RMB2685.00

acetylated alpha Tubulin 抗体 (6-11B-1) Alexa Fluor® 790

sc-23950 AF790
200 µg/ml
RMB2685.00

How do I get the correct catalog number of the Alexa Fluor 488 Labelled acetylated alpha tubulin ab (sc-23950)

Asked by: Sree
Thank you for your question. The part number for the AF488 is sc-23950 AF488. For a price quote and ship date please email [email protected].
Answered by: BlakeJ
Date published: 2025-03-27

For sc-23950, which is clone 6-11B-1 mouse monoclonal to acetylated alpha-tubulin, what PURIFICATION  METHOD was used?

Asked by: DavidFR
Thank you for your question. Santa Cruz Biotechnology antibodies are affinity purified.
Answered by: BlakeJ
Date published: 2025-03-07

1. What dilution works well for acetylated alpha Tubulin Antibody (6-11B-1) Alexa Fluor® 488 in PBMCs? 2. What isotype control is suitable for this conjugated antibody?

Asked by: Gautam
Thank you for contacting Santa Cruz Biotechnology . We would need to know what application the antibody is used for to better assist you. For help please contact [email protected]. Here are the controls we offer :https://www.scbt.com/browse/Control-IgGs-and-IgG-Conjugates/_/N-1j3ajah
Answered by: BlakeJ
Date published: 2024-05-14

We have lot # HQ422 of prodfuct sc-23950. I am getting a very week signal at 1:200 on fixed airway epithelial cells. Is this lot expired? Thanks. Shubha

Asked by: Shubha
Thank you for your question. We warranty our antibodies for 1 year from date of purchase . Lot HQ422 is not a valid lot number . Please give us a call or email us to discuss your results. [email protected] or (800)457-3801.
Answered by: BlakeJ
Date published: 2023-12-01

The product specifications list amino acids 149-448, however, in previous questions it was noted that this product recognizes Ac-K40. Can you please confirm which epitope this antibody recognizes?

Asked by: Laura
Thank you for your question. The epitope range is 149-448.
Answered by: BlakeJ
Date published: 2023-11-14

Hi, interested in buying an anti-acetyl-alpha Tubulin antibody to test the effect of HDAC8 inhibitors by WB. Wondering if I could purchase or get an small aliquot to test it before placing the order of a full product

Asked by: CarlosPR
Thank you for your question. Please contact your local distributor or technical service for further assistance.
Answered by: Dallas Tech Service
Date published: 2021-04-07

We have purchased and used acetylated α Tubulin Antibody (6-11B-1): sc-23950 antibody. It is working quite well. However we need to know the which amino acid residue the antibody is reacting with? Kindly tell me particular epitope to which ab binds.

Asked by: Nitish
Thank you for your question. This mouse monoclonal antibody recognizes endogenous levels of α-tubulin protein only when acetylated at Lys40 (Lysine 40).
Answered by: Technical Support
Date published: 2024-11-07

Hi, I would like to know which light chain is in this antibody (e.g, kappa I, II or V). I would like to undertsand if I can purify the antibody with protein L resin. I would like to find out the affinity of the antibody with protein L. Thank you!

Asked by: Foram
Thank you for your question. Since acetylated α Tubulin Antibody (6-11B-1): sc-23950 is a mouse IgG2 antibody it can be purified using Protein A or Protein A/G. For further information please contact our technical service directly.
Answered by: Technical Support Europe
Date published: 2019-02-04
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Rated 5 out of 5 by from Immunofluorescence - murine airway organoidWorked well for IF-C, using murine epithelial airway organoids, fixed in 4% PFA, permeabilization solution: 0.5% Triton in PBS, blocking solution: 1x ROTI Block, Dilution: 1:200.
Date published: 2025-04-17
Rated 4 out of 5 by from acetylated alpha Tubulin Antibody (6-11B-1)Good signal at the expected molecular weight of acetylated tubulin.
Date published: 2024-11-05
Rated 5 out of 5 by from Excellent in WB!Clear signal was detected in WB of mouse brain homogenate!
Date published: 2024-08-26
Rated 5 out of 5 by from muy buen reconocimiento de la proteínaLo probé con una linea celular de mosquito y reconoció la proteína muy bien
Date published: 2023-10-03
Rated 5 out of 5 by from Acet. alpha-tubulinAcet. Alpha-tubulin AlexaFluor 488 antibody was used 1/100 diluted in D-PBS/Live-Dead stain (1:1000), supplemented with 60µg/ml human IgG (Sigma Aldrich) at 8◦C for 30 min. After that, cells were washed in FACS buffer (D-PBS/0.1% BSA), fixed in 4% PFA at room temperature (RT), and analyzed by flow cytometry.
Date published: 2023-01-16
Rated 5 out of 5 by from GREAT ANTIBODIES!Really good antibody. Whole cell lysate, Primary: 1:200, Secondary: 1:4000
Date published: 2022-06-14
Rated 5 out of 5 by from Good antibody for ac-tubulinGood antibody for ac-tubulin detection in WB.Very clean and strong signal.
Date published: 2020-11-17
Rated 5 out of 5 by from Primary cilia - ImmunofluorescenceThe antibody works quite well at 1/1000 in fixed cells and is highly specific.
Date published: 2019-07-29
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acetylated alpha Tubulin 抗体 (6-11B-1) is rated 4.8 out of 5 by 46.
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