Date published: 2025-9-7

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ACBP 抗体 (C-9): sc-376853

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说明书
  • ACBP 抗体 C-9 是小鼠单克隆 IgG1 κ,ACBP抗体, 在4篇文献中引用,规格为200 µg/ml
  • 免疫human物种的代表全长ACBP的氨基酸1-87
  • ACBP 抗体 (C-9) 推荐用于WB, IP, IF 和 ELISA,检测human 来源的 ACBP short and long isoforms
  • 抗ACBP抗体(C-9)可与琼脂糖结合用于IP;与HRP结合用于WB、IHC(P)和ELISA;与藻红蛋白FITC结合用于IF、IHC(P)和FCM
  • 还可偶联Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594Alexa Fluor® 647,用于WB (RGB), IF, IHC(P) 和 FCM, 以及用于RGB荧光成像系统,例如iBright™ FL1000, FluorChem™, Typhoon, Azure和其他类似的系统
  • 还可偶联Alexa Fluor® 680Alexa Fluor® 790, 用于WB (NIR), IF 和 FCM; 以及用于近红外(NIR)检测系统,如LI-COR®/Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure和类似系统
  • 关于如何获取ACBP (C-9): sc-376853免费10 µg小样,联系我们技术服务部门 (或者您当地的代理商)了解详情。
  • m-IgG Fc BP-HRP1 BP-HRP">m-IgG1 BP-HRPm-IgGκ BP-HRP是ACBP Antibody (C-9) 适用于 WB 应用。 的首选辅助检测试剂。这些试剂现与ACBP Antibody (C-9) 打包提供(请参阅下面的订购信息)。

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関連項目

ACBP抗体(C-9)是一种IgG1 κ小鼠单克隆ACBP抗体(也称为ACBP抗体),可通过蛋白质印迹(WB)、免疫沉淀(IP)、免疫荧光(IF)和酶联免疫吸附测定(ELISA)检测人源的ACBP蛋白。ACBP抗体(C-9)既有非偶联形式的抗ACBP抗体,也有多种偶联形式的抗ACBP抗体,包括琼脂糖、HRP、PE、FITC和多种Alexa Fluor®偶联物。长链酰基辅酶A酯(LCAs)在代谢中既作为底物又作为中间产物,并作为各种细胞内功能的调节剂。酰基辅酶A结合蛋白(ACBP)以高亲和力特异性结合LCA并调节其可用性。ACBP在包括人、大鼠、青蛙、昆虫、植物和酵母在内的多种生物体中结构和功能上是保守的。编码人类ACBP的基因DBI位于2号染色体上,在肝脏、比目鱼肌和心脏中高表达。ACBP蛋白在脂生成和从头脂肪酸合成水平高的细胞中也很丰富。在脂肪细胞分化过程中,ACBP的表达显著诱导。DBI是增殖物激活受体(PPAR)γ的靶基因,并直接由PPARγ/RXRα和PPARα/RXRα激活,但不由PPARδ/RXRα激活。除了酰基辅酶A的结合和转运外,ACBP还涉及γ-氨基丁酸A型受体的结合、类固醇生成和肽激素的释放。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

ACBP 抗体 (C-9) 参考文献:

  1. 酰基-CoA 结合蛋白在酰基-CoA 代谢和酰基-CoA 介导的细胞信号传导中的作用。  |  Knudsen, J., et al. 2000. J Nutr. 130: 294S-298S. PMID: 10721891
  2. 大鼠骨骼肌中酰基辅酶 A 结合蛋白的表达具有纤维类型特异性,但不受中度耐力训练的影响。  |  Franch, J., et al. 2002. Pflugers Arch. 443: 387-93. PMID: 11810207
  3. 编码 Acyl-CoA 结合蛋白的基因通过一个在人类和啮齿类动物之间功能一致的内含反应元件被过氧化物酶体增殖激活受体 gamma 激活。  |  Helledie, T., et al. 2002. J Biol Chem. 277: 26821-30. PMID: 12015306
  4. 酰基-CoA 结合蛋白(ACBP)及其与脂肪酸结合蛋白(FABP)的关系:概述。  |  Knudsen, J. Mol Cell Biochem. 98: 217-23. PMID: 2266962
  5. 酰基辅酶A结合蛋白(ACBP):自噬检查点,可作为改善癌症免疫监视的靶点。  |  Montégut, L., et al. 2024. Oncoimmunology. 13: 2413200. PMID: 39381588
  6. 中和自噬抑制性组织激素 DBI/ACBP(地西泮结合抑制剂、酰基辅酶 A 结合蛋白)可增强抗癌免疫监视。  |  Montégut, L., et al. 2024. Autophagy. 20: 2836-2838. PMID: 39419485
  7. ACBP/DBI中和用于脂肪肝的实验治疗。  |  Motiño, O., et al. 2024. Cell Death Differ.. PMID: 39550516
  8. 酰基辅酶 A 结合蛋白(ACBP)在库欣综合征中的致病作用。  |  Pan, H., et al. 2024. Nat Metab. 6: 2281-2299. PMID: 39578649
  9. 糖皮质激素诱导的自噬依赖性肝细胞分泌 DBI/ACBP 决定了库欣综合征的发病机制  |  Pan, H., et al. 2024. Autophagy.. PMID: 39663572
  10. 与人类酰基-CoA 结合蛋白/地西泮结合抑制剂有关的假基因的分子克隆和染色体定位。  |  Gersuk, VH., et al. 1995. Genomics. 25: 469-76. PMID: 7789980
  11. 酰基-CoA 结合蛋白(ACBP)/地西泮结合抑制剂(DBI)的功能。  |  Knudsen, J., et al. Mol Cell Biochem. 123: 129-38. PMID: 8232254
  12. 鉴定地西泮结合抑制剂/酰基-CoA 结合蛋白为固醇调节元件结合蛋白反应基因。  |  Swinnen, JV., et al. 1998. J Biol Chem. 273: 19938-44. PMID: 9685328

订购信息

产品名称产品编号规格价格数量收藏夹

ACBP 抗体 (C-9)

sc-376853
200 µg/ml
RMB2377.00

ACBP (C-9): m-IgG Fc BP-HRP 套装

sc-529945
200 µg Ab; 10 µg BP
RMB2662.00

ACBP (C-9): m-IgGκ BP-HRP 套装

sc-523117
200 µg Ab, 40 µg BP
RMB2662.00

ACBP (C-9): m-IgG1 BP-HRP 套装

sc-543779
200 µg Ab; 20 µg BP
RMB2662.00

ACBP 抗体 (C-9) AC

sc-376853 AC
500 µg/ml, 25% agarose
RMB3129.00

ACBP 抗体 (C-9) HRP

sc-376853 HRP
200 µg/ml
RMB2377.00

ACBP 抗体 (C-9) FITC

sc-376853 FITC
200 µg/ml
RMB2482.00

ACBP 抗体 (C-9) PE

sc-376853 PE
200 µg/ml
RMB2580.00

ACBP 抗体 (C-9) Alexa Fluor® 488

sc-376853 AF488
200 µg/ml
RMB2685.00

ACBP 抗体 (C-9) Alexa Fluor® 546

sc-376853 AF546
200 µg/ml
RMB2685.00

ACBP 抗体 (C-9) Alexa Fluor® 594

sc-376853 AF594
200 µg/ml
RMB2685.00

ACBP 抗体 (C-9) Alexa Fluor® 647

sc-376853 AF647
200 µg/ml
RMB2685.00

ACBP 抗体 (C-9) Alexa Fluor® 680

sc-376853 AF680
200 µg/ml
RMB2685.00

ACBP 抗体 (C-9) Alexa Fluor® 790

sc-376853 AF790
200 µg/ml
RMB2685.00

Is there a version of this antibody for IP that works in mouse please?

Asked by: TTW02
Thank you for your question. Unfortunately, this is not available at this moment.
Answered by: Technical Service SH
Date published: 2023-02-15

Is there a version of this antibody that works in mouse please?  

Asked by: mikeklein
Thank you for your question. Unfortunately we do not offer a mouse reactive ACBP antibody at this time. We are still testing and gathering data to show on our website. Check back for updates!
Answered by: Tech Service
Date published: 2023-02-14

What is the recommended starting dilution for Western blot for sc-376853: ACBP (C-9) monoclonal antibody?

Asked by: DefinitelyNotMatt
The recommended starting dilution for Western blot is 1:100 with a dilution range of 1:100-1:1000. This information, along with other technical specifications, is available in the recommended protocol: https://www.scbt.com/scbt/resources/protocols/western-immuno-blotting
Answered by: Technical Support
Date published: 2017-03-22
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Rated 5 out of 5 by from Very good signal in human samplesWorks very well in human tissue but be careful, it won't work with mouse samples.
Date published: 2018-04-06
Rated 1 out of 5 by from NegativeIt does not look the mouse ACBP. Unfortunatly It is not useful in mouse.
Date published: 2017-08-28
Rated 5 out of 5 by from Good Western blot data of ACBP expression in nonGood Western blot data of ACBP expression in non-transfected and human ACBP transfected 293T whole cell lysates. -SCBT QC
Date published: 2014-02-11
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ACBP 抗体 (C-9) is rated 3.7 out of 5 by 3.
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