Date published: 2026-10-24

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A20/TNFAIP3 Antibody (59A426) - Western Blotting - Image 15024
A20 抗体 (59A426): sc-52910. Jurkat (A) 和 Daudi (B) 全细胞裂解液中 A20 表达的 Western 印迹分析.
A20/TNFAIP3 Antibody (59A426) - Western Blotting - Image 15024
A20 抗体 (59A426): sc-52910. Jurkat (A) 和 Daudi (B) 全细胞裂解液中 A20 表达的 Western 印迹分析.
A20 抗体 (59A426): sc-52910. Jurkat (A) 和 Daudi (B) 全细胞裂解液中 A20 表达的 Western 印迹分析.

A20/TNFAIP3 抗体 (59A426): sc-52910

4.0(3)
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说明书
  • A20/TNFAIP3 抗体 59A426 是小鼠单克隆 IgG1, 在6篇文献中引用，提供 50 µg/0.5 ml
  • 针对全长融合蛋白A20（来源于human）
  • 推荐用于 mouse, rat 和 human 来源的A20 WB, IP 和 ELISA检测
  • 看 A20/TNFAIP3 (A-12): sc-166692，可查看有标记的 A20/TNFAIP3 抗体，包括AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 和 790
  • m-IgG Fc BP-HRP和 m-IgG1 BP-HRP是A20/TNFAIP3 Antibody (59A426) for WB applications. 的首选辅助检测试剂，这些试剂现与A20/TNFAIP3 Antibody (59A426) 打包提供（请参阅下面的订购信息）。
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A20抗体（59A426）是一种小鼠单克隆IgG1 kappa轻链抗体，可通过蛋白质印迹（WB）、免疫沉淀（IP）和酶联免疫吸附测定（ELISA）等方法检测小鼠、大鼠和人类样本中的A20。抗A20抗体（59A426）以非结合形式提供，可用于多种实验。A20，也称为TNFAIP3，是一种重要的Cys2/Cys2锌指蛋白，在肿瘤坏死因子（TNF）和白细胞介素1（IL-1）等多种炎症刺激下会上调。A20是核因子κB（NFκB）信号的负调控因子，对控制炎症反应和细胞存活至关重要。A20（59A426）单克隆抗体有助于研究A20如何抑制NFκB激活并终止炎症信号，防止可能导致组织损伤的过度免疫反应。A20的结构包括七个锌指结构域，其中四个对抑制TNF诱导的NFκB激活至关重要。A20与TRAF2、TRAF6和IκB激酶（IKK）γ等关键蛋白相互作用，进一步增强了细胞死亡和存活途径的调节。TXBP151是一种新型A20结合蛋白，它的发现表明A20可能还具有抗凋亡特性，这使A20成为治疗各种炎症性疾病的潜在靶标。

仅限研究使用。不适用于诊断和治疗用途。

Alexa Fluor® 是Molecular Probes Inc., OR., USA的商标

LI-COR®和 Odyssey® 是LI-COR Biosciences的注册商标

A20/TNFAIP3 抗体 (59A426) 参考文献:

  1. A20在自身免疫性疾病中的作用。  |  Zhang, M., et al. 2016. Immunol Res. 64: 337-44. PMID: 26135958
  2. A20关键控制小胶质细胞活化并抑制炎症小体依赖性神经炎症。  |  Voet, S., et al. 2018. Nat Commun. 9: 2036. PMID: 29789522
  3. A20抑制牙周骨吸收和NLRP3介导的M1巨噬细胞分化。  |  Hou, L., et al. 2022. Exp Cell Res. 418: 113264. PMID: 35714941
  4. A20控制RANK依赖性破骨细胞形成和骨骼生理。  |  Martens, A., et al. 2022. EMBO Rep. 23: e55233. PMID: 36194667
  5. 成纤维细胞 A20 控制着纤维化的易感性，DREAM 对它的抑制促进了多个器官的纤维化。  |  Wang, W., et al. 2022. Nat Commun. 13: 6358. PMID: 36289219
  6. 内皮细胞PTP4A1通过USF1/A20轴介导的NF-κB失活减轻血管炎症。  |  Cho, MJ., et al. 2023. Cardiovasc Res. 119: 1265-1278. PMID: 36534975
  7. 双白藜芦醇调节Nrf2/A20/eEF1A2轴，通过抑制化脓减轻脑缺血再灌注损伤  |  Bai, W., et al. 2023. Biomed Pharmacother. 165: 115057. PMID: 37399716
  8. P7C3-A20通过抑制过度自噬和细胞凋亡来治疗大鼠的创伤性脑损伤。  |  Yang, Z., et al. 2024. Neural Regen Res. 19: 1078-1083. PMID: 37862211
  9. 肝星状细胞中的A20通过抑制DCLK1-JNK通路依赖性趋化因子来抑制慢性肝炎。  |  Watakabe, K., et al. 2024. FASEB J. 38: e23757. PMID: 38965999
  10. 急性髓性白血病的化疗耐药性是由 A20 抑制自发性坏死介导的。  |  Culver-Cochran, AE., et al. 2024. Nat Commun. 15: 9189. PMID: 39448591

订购信息

产品名称产品编号规格价格数量收藏夹

A20/TNFAIP3 抗体 (59A426)

sc-52910
50 µg/0.5 ml
CNY2422.00

A20/TNFAIP3 (59A426): m-IgG Fc BP-HRP 套装

sc-538962
50 µg Ab; 10 µg BP
CNY2715.00

A20/TNFAIP3 (59A426): m-IgG1 BP-HRP 套装

sc-541179
50 µg Ab; 20 µg BP
CNY2715.00

m-IgG Fc BP-HRP and m-IgG1 BP-HRP 是 A20/TNFAIP3 Antibody (59A426) for WB首选应用二抗。这些试剂现在以套装形式提供A20/TNFAIP3 Antibody (59A426) 您好，我想咨询下，为什么首选这个二抗，平时用的鼠二抗不行么？

Asked by: DD0221
感谢您的提问。 平时用的鼠二抗是可以的。 我们公司不提供传统的二抗，使用得是小鼠结合蛋白，可以替代传统的抗小鼠的二抗。 Thank you for your question. Of course, you can choose the conventional anti-mouse secondary antibody. We offer the mouse binding protein, which can replace the conventional secondary antibody.
Answered by: Ling Chen
Date published: 2022-06-14

I would like to use A20 Antibody (59A426): sc-52910 for double staining with another mouse monoclonal primary antibody. Is this possible?

Asked by: Trav11
Thank you for your question. In cases like this, we recommend using our directly conjugated mouse monoclonal primary antibodies. Currently, sc-52910 is not available directly conjugated, but we have an alternative A20 antibody (sc-166692) that is available conjugated to HRP, FITC, PE, Alexa Fluor® 488 and Alexa Fluor® 647. If you have any further questions or concerns, please contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Technical Support 15
Date published: 2017-01-25
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Rated 2 out of 5 by A20protein from some non-specific bandsWestern blotting in U2OS and HUVEC w/o overexpression showed multiple bands. One of them might be real, but the A12 clone looks better.
Date published: 2017-12-13
Rated 5 out of 5 by cjMara from Solid choice for IP/WBThe (59A426) clone is a solid antibody for use in WB. However, the alternative clone, A20 (A-12): sc-166692, is overall a better antibody with publications and data in a broad range of applications.
Date published: 2017-01-12
Rated 5 out of 5 by MS from Strong bands present in western blot analysisStrong bands present in western blot analysis of A20 expression in Jurkat and Daudi whole cell lysates. -SCBT QC
Date published: 2013-08-05
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A20/TNFAIP3 抗体 (59A426) is rated 4.0 out of 5 by 3.
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