Date published: 2025-10-10

021-6093-6350

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MADP-1激活剂

FAM152A Activators encompass a range of chemical compounds that indirectly enhance the functional activity of FAM152A through modulation of intracellular signaling pathways, primarily those involving cyclic adenosine monophosphate (cAMP). Forskolin, a diterpene, directly stimulates adenylate cyclase, thereby increasing cAMP levels and activating protein kinase A (PKA). This activation can lead to phosphorylation of substrate proteins that are part of the FAM152A functional network, thus enhancing FAM152A's activity. Similar in their effects, Rolipram and IBMX raise intracellular cAMP levels by inhibiting phosphodiesterases, with Rolipram being specific to PDE4 and IBMX acting more broadly. The increased cAMP then activates PKA, which could phosphorylate and activate proteins associated with FAM152A, boosting its activity. Likewise, endogenous compounds such as PGE2, epinephrine, and isoproterenol bind to their respective receptors, which signal through G proteins to increase cAMP and activate PKA, leading to a cascade of phosphorylation events that can enhance FAM152A's function.

The influence of FAM152A activators extends to other endogenous signaling molecules such as glucagon, dopamine, and histamine, which all enhance FAM152A activity by stimulating adenylate cyclase through their receptors, increasing cAMP, and subsequently activating PKA. Anagrelide, another activator, operates by inhibiting phosphodiesterase-3, thereby raising cAMP levels and enhancing FAM152A activity through activated PKA and its downstream effects on FAM152A-associated proteins. Furthermore, the exogenous compound cholera toxin irreversibly activates the Gs alpha subunit, resulting in sustained cAMP production and potential enhancement of FAM152A function through PKA-driven signaling.

関連項目

产品名称CAS #产品编号数量价格应用排名

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
¥857.00
¥1692.00
¥8179.00
¥15626.00
¥23128.00
73
(3)

佛司可林直接激活腺苷酸环化酶,导致环磷酸腺苷(cAMP)产生增加,从而激活蛋白激酶 A(PKA)。然后,PKA 可使 MADP-1 磷酸化,导致其在细胞内的功能激活。

IBMX

28822-58-4sc-201188
sc-201188B
sc-201188A
200 mg
500 mg
1 g
¥1794.00
¥3554.00
¥6747.00
34
(1)

异丁基甲基黄嘌呤(IBMX)可抑制磷酸二酯酶,防止 cAMP 分解。cAMP 水平升高会导致 PKA 激活,而 PKA 会磷酸化并激活 MADP-1。

(−)-Epinephrine

51-43-4sc-205674
sc-205674A
sc-205674B
sc-205674C
sc-205674D
1 g
5 g
10 g
100 g
1 kg
¥451.00
¥1151.00
¥2223.00
¥19619.00
¥184179.00
(1)

肾上腺素与肾上腺素能受体结合并激活受体,从而刺激腺苷酸环化酶产生 cAMP。cAMP 的增加会激活 PKA,然后通过磷酸化激活 MADP-1。

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
¥632.00
¥1760.00
¥3046.00
¥7503.00
37
(1)

前列腺素E2(PGE2)与其受体相互作用,通过G蛋白发出信号,激活腺苷酸环化酶,从而增加cAMP水平。cAMP水平升高可以激活PKA,从而激活MADP-1。

Histamine, free base

51-45-6sc-204000
sc-204000A
sc-204000B
1 g
5 g
25 g
¥1038.00
¥3125.00
¥10932.00
7
(1)

组胺可以与其G蛋白偶联受体结合,从而激活腺苷酸环化酶并增加cAMP水平。PKA的激活会导致MADP-1的磷酸化并激活。

Dopamine

51-61-6sc-507336
1 g
¥3272.00
(0)

多巴胺与其受体结合,特别是D1样受体,可刺激腺苷酸环化酶,导致cAMP增加,进而激活蛋白激酶A。蛋白激酶A可磷酸化并激活MADP-1。

PACAP(6-38)

137061-48-4sc-391136
sc-391136A
500 µg
1 mg
¥5968.00
¥10312.00
(0)

垂体腺苷酸环化酶激活多肽(PACAP-38)与其受体结合,导致腺苷酸环化酶激活、cAMP增加和PKA激活。然后,PKA可以磷酸化并激活MADP-1的功能。

Anagrelide

68475-42-3sc-491875
25 mg
¥1658.00
(0)

阿那格雷抑制磷酸二酯酶 III,导致 cAMP 增加并激活 PKA。然后,PKA 可以磷酸化并激活 MADP-1。

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
¥846.00
¥2392.00
18
(1)

罗利普仑会选择性地抑制磷酸二酯酶 IV,从而导致细胞中的 cAMP 水平升高,随后激活 PKA。PKA 可使 MADP-1 磷酸化,从而激活 MADP-1。

Zardaverine

101975-10-4sc-201208
sc-201208A
5 mg
25 mg
¥993.00
¥4276.00
1
(0)

扎达维林是磷酸二酯酶 III 和 IV 的双重抑制剂,可导致 cAMP 水平升高和 PKA 激活。然后,PKA 可以磷酸化并激活 MADP-1。